Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"MCF-7 cell line"”.
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The Effects of 1,25-Dihydroxyvitamin D3, Docosahexaenoic Acid and 5-Fluorouracil on Human Breast Cancer Cells
… alone. In this study, human mammary epithelial cells from the MCF-7 cell line were treated with 25 μM DHA, 1 μM calcitriol, and 15 μM 5-Fluorourocil alone and in multiple combinations for 72 hours. Both DHA and 5-Fluorouracil slowed growth significantly (p < 0.05). In contrast, vitamin D did not …
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Design, synthesis and biological evaluation of bioorganometallic metallarectangles
… Additionally, the evolution of resistant cancer cell sub-types has rendered many of these highly efficacious platinum drugs, ineffective. Utilizing alternative platinum group metals (PGMs), such as iridium and ruthenium, and incorporating known pharmacophoric scaffolds within the framework of a …
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Electrophilic Affinity Labels and Fluorescent Conjugates for the Estrogen Receptor (Norhexestrol, Aziridine, Hexestrol, Fluorescein, Alkylator)
… ligand as determined in human breast cancer cell growth experiments (MCF-7 cell line). Norhexestrol aziridine 34 ((6R*,7S*)-1-(N-aziridinyl)-6,7-bis(4-hydroxyphenyl)-5-nonanone) had the most potential as an estrogenic affinity labeling agent because of its agonistic properties, and its rapid, …
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COMPARATIVE PROTEOMICS STUDIES OF SOLUBLE NUCLEAR PROTEINS OF DRUG SUSCEPTIBLE AND RESISTANT HUMAN BREAST CANCER MCF-7 CELLS
… anticancer drugs target the nuclei of the cancer cells, differential expression of nuclear proteins may play crucial roles as cancer cells acquire drug resistance. Thus I have carried out a comparative proteomics research project to study differential expression of nuclear proteins in drug …
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Anti-proliferative effect of methyl gallate isolated from mangifera pajang kosterman in selected cancer cell lines
… aromatic ester, methyl gallate which induce the cell cycle arrest and killing mechanism via apoptosis in selected cancer cell line. Chromatography methods were used in this study to isolate methyl gallate (C8H8O5) from methanol crude extract. Identification of the isolated compound was done by …
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Altered estrogen receptor and transforming growth factor pathways in models of estrogen-autonomous and of antiestrogen-resistant MCF-7 human breast cancer cells
… used clinically. We developed two models in the MCF-7 cell line, an estrogen receptor-positive human breast cancer cell line, to assess the relative importance of the estrogen receptor pathway and the transforming growth factor (TGF) pathways during this progression. MCF-7 cells maintained …
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Designing Compounds that Probe the Phosphatidylinositol 3-Kinase Signalosome
… 3-kinases (PI3K) are major regulators of many cellular functions, and its hyperactivation is a major target for anticancer drug discovery. PI3Kα is the isoform most implicated in cancer, and this thesis is dedicated to investigating how specific protein-ligand interactions in the active site …
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Biological Evaluation Of The Vaccine Candidate Tf-Ps A1 And A One-Pot Multicomponent Coupling/cyclization For Natural Product Herbicide (±)-Thaxtomin A
… assays and a SCID mouse study involving MCF-7 induced tumors. While the induced antibody titers were not substantial these antibodies were shown to have ~30% cytotoxicity in ADCC and CMC based assays against the breast cancer cell line MCF-7. In addition passive transfer of the IgG …
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The effect of CLAs on the expression of PKC isoforms and cell viability in breast cancer cell lines.
… modulated in many androgen sensitive tumour cell lines. Increased expression of some PKC isoforms has also been linked to immortality in many cancer cell lines. Conjugated linoleic acids(CLAs) are naturally occurring positional and geometric isomers of the fatty acid linoleic acid (LA). CLAs …
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Biomechanical regulation of cancer metastasis
… cancer through the body. To metastasize, cancer cells must leave the primary tumor, access the circulatory system, adhere to the endothelium of the metastatic site, and migrate out into the surrounding tissue. A major limitation in the discovery and development of drugs that prevent the spread of …
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The role of the kisspeptin receptor, KISS1R, in breast cancer cell proliferation, invasion and migration.
… the role of endogenous KISS1R in breast cancer cell proliferation, invasion and migration. Firstly, endogenous protein expression of the receptor was determined in 3 breast cancer cell lines by western blotting. Secondly, the signalling potential of the receptor was determined by assessing …
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Characterisation of Pharmacological Mechanisms and Potential Therapeutic uses of FK866
… characteristics of FK866 in different cancer cell lines and to determine if decreasing intracellular NAD+ levels can be used as a co-therapy strategy to improve the efficacy of current and new chemotherapy treatments. Experiments measuring cell vitality showed that FK866 dose-dependently …
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Correlation between the expression of integrins and their role in cancer progression. Expression pattern of integrins αvβ3, αvβ5 and α5β1 in clinical and experimental tumour samples
The integrins play a crucial role in cancer cell proliferation, migration, differentiation, survival and angiogenesis. It has been shown that integrin expression is positively correlated to cancer dissemination, this suggests targeting selected integrins as an anti-metastatic strategy. The aim of …
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Enhanced Etoposide Solubility and Anticancer Activity using Complexation and Nanotechnology
Etoposide is a first line treatment for different cancer types that can be used either alone or in combination with other therapeutic agents. However, systemic toxicity, variable oral bioavailability, and high drug resistance are the three main drawbacks which hamper etoposide activity. The central …
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Exploring the in vitro effects of chronic methamphetamine exposure on selected cancer cell lines
… well documented in multiple organ systems, the cellular consequences of chronic METH exposure in cancer biology remain poorly defined. Understanding how tumour cells respond to sustained psychostimulant-induced stress may provide insight into metabolic and redox adaptations relevant to cancer …