Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 280 for “"MCF-7"”.
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Inhibition of MCF-7 Breast Cancer Cell Proliferation by Diarylthiourea Analogs
<p>No abstract available</p>
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Interaktion von Doxorubicin und antioxidativen Vitaminen bei den Mammakarzinom-Zellinien MCF-7 und MDA-MB468
… Arbeit wurde an zwei Mammakarzinomzellen (MCF-7 und MDA-MB468) die Interaktion der Antioxidantien Vitamin C und E mit dem Zytostatikum Doxorubicin untersucht; Superoxiddismutase (SOD) diente als Kontrollantioxidans. Gemessen wurde die Zellproliferation (anhand von Zellzahl, Zellvolumen und …
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Transcriptional regulation of glycosyltransferase genes in MCF-7 human breast cancer cell line following drug treatment
… thesis, the results of Microarray experiments on MCF-7 human breast cancer cell-lines are analysed using statistical and computational tools to identify differentially expressed genes. Here a bioinformatics analysis of the regulation of GT gene expressions was performed to identify a set of …
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Modulation of gene expression by estrogen and protein kinase activators in MCF-7 human breast cancer cells
… of gene expression in three different cases in MCF-7 human breast cancer cells, which contain high levels of estrogen receptor and low levels of progesterone receptor.
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Characterization of the molecular mechanisms underlying retinoic acid induced growth inhibition in MCF-7 human breast cancer cells.
… in the E2 dependent breast carcinoma cell line, MCF-7. We have found that RA induced accumulation of cells in G1 was correlated with decreased phosphorylation of the retinoblastoma protein (pRb). It also resulted in a down regulation of cyclin dependent kinase 2 (cdk2) and cyclin D1 gene …
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Study of anti-cancer effect of winter worm and summer grass on Mcf-7 human breast cancer cells
… the C. militaris extract inhibited growth of MCF-7 human breast cancer cells in a dose- and time-dependent manner. The inhibitory effect of the C. militaris extract on MCF-7 cells was via an apoptosis cascade by inducing the expression of pro-apoptotic genes and by suppressing anti-apoptotic …
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COMPARATIVE PROTEOMICS STUDIES OF SOLUBLE NUCLEAR PROTEINS OF DRUG SUSCEPTIBLE AND RESISTANT HUMAN BREAST CANCER MCF-7 CELLS
… proteins in drug resistant human breast cancer MCF-7 cells. Two dimensional gel electrophoresis and stable isotope labeling by amino acids in cell culture are used to conduct the study. Protein identification is acquired by peptide fingerprinting or microsequencing. Relative quantitation of the …
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Photofrin-Mediated Electroporation-Assisted Photodynamic Therapy of MCF-7 Human Breast Cancer and B16-F10 Mouse Melanoma Cells
… in intracellular Photofrin content in both MCF-7 and B16-F10 cell lines in those samples subjected to electroporation and an equal Photofrin concentration compared to the non-electroporated samples. In evaluating the cytotoxicity of photodynamic therapy via the clonogenic assay, we observed …
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Mechanisms of 17-beta-estradiol regulation of the proto-oncogene Bcl-2 in MCF-7 human breast cancer cells.
… constructs stably transfected into MCF-7 cells. An approximately 1.7 kilobase (kb) sequence which directed estrogen-dependent regulation of Bcl-2 expression in these stable MCF-7 clones was identified. Another agent which may play a role in the regulation of Bcl-2 expression is the …
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Induction and characterization of de novo methylation by benzo[A]pyrene in the cancer cell lines MCF-7 and MDA-MB-231
… ability to alter cytosine methylation patterns. MCF-7 and MDA-MB-231 human breast cancer cells were treated for a period of sixty days with 100 nM benzo[a]pyrene. The methylation status of two genes, Ecadherin and GSTP 1 were examined using methyl-specific PCR and Southern blot analysis. After …
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Altered estrogen receptor and transforming growth factor pathways in models of estrogen-autonomous and of antiestrogen-resistant MCF-7 human breast cancer cells
… used clinically. We developed two models in the MCF-7 cell line, an estrogen receptor-positive human breast cancer cell line, to assess the relative importance of the estrogen receptor pathway and the transforming growth factor (TGF) pathways during this progression. MCF-7 cells maintained …
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The Cytoplasmic Domain of Membrane-type 1 Matrix Metalloproteinase is Required for its Survival-Promoting, but not its Migration-Promoting Function in MCF-7 Breast Cancer Cells
… by ectopically expressing MT1-MMP variants in MCF-7 cells. CD alteration by substitution or deletion did not abolish the migration-promoting effects of MT1-MMP, but did decrease cell survival and increase apoptosis. Expression of CD-altered MT1-MMP resulted in a protrusive cell morphology in 3D …
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Effet de l'acide rétinoïque sur l'amplification du gène her2/neu chez la lignée MCF-7 traitée avec le 9-10 diméthyl-1,2-benzanthracène
… l'amplification du gène her2/neu chez la lignée MCF-7 traitée avec le 9,1-diméthyl-1,2-benzanthracène (DMBA) et de comprendre le rôle de ce dernier dans la pathogenèse du cancer du sein. La lignée cellulaire MFC-7 a été mise en culture et des tests de viabilité ont été faits par rapport certains …
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Biological Potencies and Mechanism of Action of Estrogens and Antiestrogens in Primary Cell Cultures of Human Endometrium and in Mcf-7 Human Breast Carcinoma Cells in Vitro
Primary cultures of human endometrial cells were used to examine the direct effects of estrogens on progesterone receptor levels in vitro. Cells, grown in Dulbecco's EMEM, showed maximal stimulation of progesterone receptor (PR, 7-fold) after a 3-4 d incubation with 10nM estradiol (E(,2)). The
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The effects of various combinations of different classes of anticancer drugs and tyrosine kinase inhibitors on the human MCF-7 and triple-negative MDA-MB 231 breast carcinoma cell lines
… individually and in combination, on human MCF-7 breast carcinoma cells and a triple negative breast cancer (TNBC) cell line (MDA-MB-231), with specific focus on P-gp and EGFR inhibition. Analyses of MCF-7 and MDA-MB-231 TNB carcinoma cells exposure to DOX, CDDP and EGFRi included growth and …
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Proteomic Map of ER+ Breast Cancer Cell Cycle
… proteomics strategy to enable the comparison of MCF-7 ER+ (cancer) and MCF-10A (non-tumorigenic) epithelial breast cells. Samples were analyzed by liquid chromatography tandem mass spectrometry (LC-MS/MS) followed by a label-free quantitation approach, i.e., spectral counting, for differential …
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Investigating the Involvement of RNA-Binding Protein ZFP36L1 in Breast Cancer Progression
… CRISPR Cas9-derived knockout of ZFP36L1 in the MCF-7 breast cancer cell line, characterised by luminal A molecular subtype. Functional assays demonstrated that the loss of ZFP36L1 in MCF-7 cells reduced the cell migration capacity and reduced cell population in the G1 phase of the cell cycle. …
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Antitumor activity of antimalarials in human breast cancer cells
Previously we showed that quinidine arrested MCF-7 cells in G1 phase of the cell cycle and led to a G1 to G0 transition followed by apoptotic cell death (Wang et al., 1998). The present experiments demonstrate that MCF-7, MCF-7ras, T47D, MDA-MB-231, and MDA-MB-435 cells transiently differentiate …
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Differential membrane-type matrix metalloproteinase expression in phenotypically defined breast cancer cell lines: Comparison of MT-MMP expression in environmentally-challenged 2D monolayer cultures and 3D multicellular tumour spheroids
… using different breast cancer cell lines (MCF-7, T47D, MDA-MB-468 and MDA-MB-231) was performed. Unexpected detection of MT1-MMP in MCF-7 MCTS warranted further investigation. MT1-MMP expression in different micro-environmental conditions, including hypoxia and nutrient deprivation …
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