Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"MCF-10A"”.
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Évaluation in vitro de l'effet antitumoral de nouveaux composés sulfonates à l'aide de lignées de cellules cancéreuses du sein
… les cellules épithéliales humaines cancéreuses (MCF-7) et non-cancéreuses (MCF-10A) du sein. Nous avons aussi évalué l’effet des composés sur le cycle cellulaire et l’apoptose. De plus, nous avons investigué si les composés p-methoxyphenyl />-toluenesulfonate (22) et 4-Allyloxyphenyl …
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Ursolic acid and oleanolic acid as novel therapeutic agents in breast cancer
… in breast cancer were studied in vitro in MCF-7 breast cancer cells and MCF10A breast cells. In this study the first aim was to establish the influence of OA and UA on cell growth and to see if opposing proliferation patterns could observed between the presumably ERɑ negative (ERɑ/ß - /+) …
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Proteomic Map of ER+ Breast Cancer Cell Cycle
… proteomics strategy to enable the comparison of MCF-7 ER+ (cancer) and MCF-10A (non-tumorigenic) epithelial breast cells. Samples were analyzed by liquid chromatography tandem mass spectrometry (LC-MS/MS) followed by a label-free quantitation approach, i.e., spectral counting, for differential …
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Mechanotransduction of subcellular AMPK and its role in breast cancer cell migration
… fluid flow than normal epithelial cells (MCF-10A) in the regulation of FAK and Src. AMPK was activated in the mitochondria of MDA-MB-231 cells by interstitial fluid flow, but not in other subcellular domains (i.e., cytosol, plasma membrane, and nucleus). Subcellular AMPK in MCF-10A cells …
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Die Rolle der Phosphorylierung von FADD/MORT1
… bewirkt, wurden die Brustkarzinomzellinie MCF-7 und die spontan immortalisierte epitheliale Brustzellinie MCF-10A mit den adenoviralen Vektoren AdV-C-FADD Wildtyp, AdV-C-FADD S194A und AdV-C-FADD S194E infiziert. Die Expression des Wildtyps führte nur in der Zellinie MCF-10A zu einem …
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Development of Novel Peptide-Doxorubicin Conjugates for Targeting Triple-Negative Breast Cancer
… assessed against MDA-MB-231, MDA-MB-468, and MCF-10A cells using MTT assay. The PDC showed similar toxicity as free Dox towards the TNBC cell lines and was less toxic towards the normal cells. The in vivo efficacy experiments and pharmacokinetics studies with PDC were completed using …
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Radiobiological and microdosimetric evaluation of proton FLASH versus conventional proton and conventional X-ray irradiation. A comparative study on cell survival and DNA damage
… όσο και υγιή επιθηλιακά κύτταρα μαστού (MCF-10A) ακτινοβολήθηκαν με ακτίνες Χ (0,03 Gy/sec), συμβατικά πρωτόνια (0,6 Gy/sec) και πρωτόνια FLASH (270 Gy/sec). Η κινητική των βλαβών του DNA αξιολογήθηκε μέσω της ποσοτικοποίησης των παραμέτρων των εστιών γH2AX και 53BP1, ενώ η μακροπρόθεσμη …
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Protein Set for Normalization of Quantitative Mass Spectrometry Data
… from cell cycle experiments performed with MCF-7, an estrogen receptor positive breast cancer cell line, and MCF-10A, a non-tumorigenic immortalized breast cell line. The protein set was selected from a list of 3700 proteins identified in the different cellular sub-fractions and cell cycle …
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A Microfabricated Bioimpedance Sensor with Enhanced Sensitivity for Early Breast Cancer Detection
… of highly metastatic MDA-MB-231 and normal MCF 10A breast epithelial cells and use this information to detect a very small number of breast cancer cells present in a background of normal breast cells and other cells that are typically present in a human biopsy sample.To accomplish this, a …
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Anticancer activity of peach and plum extracts against human breast cancer in vitro and in vivo
… breast cancer cells over the estrogen-dependent MCF-7 or the normal MCF-10A breast cells. Similarly, BS extracts, though less effective than RL extracts, showed greater effects on MDA-MB-435 cells compared to the other cell lines. Fractionation of RL extracts into different groups of phenolic …
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Characterization of perillyl alcohol as a cell migration-inhibiting compound
… migration-inhibiting properties in MCF-10A normal and MDA-MB 435 cancerous breast cells. Perillyl alcohol at 0.5 mM inhibited normal breast cell migration while it failed to affect cancer cell migration. Finally, we examined the loss of prenylation of RhoA, a small GTPase protein …
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Synthesis, Characterization, and Evaluation of Amphiphilic Cell-Penetrating Peptides as siRNA Delivery Tools for Cancer Therapy
… all the studied cell lines, such as MDA-MB-231, MCF-7 and MCF-10A, even at the 5 μM range. We tested the cellular uptake of some of the conjugates for siRNA uptake, but these did not show significant uptake, so we stopped pursuing this series of peptides for further studies.</p> <p>Oleyl …
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Cooperative Genomic Events Driving Mutant TP53-Driven DCIS Progression
… these genes with mutant <em>TP53</em> in human MCF-10A cells using acinar morphogenesis and migration assays. Overexpression of <em>TMEM267</em> in cells with mutant <em>TP53</em> caused a significant increase in the filled duct, DCIS-like phenotype. RNAscope revealed increased expression of …
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Molecular aspects of the link between obesity, insulin resistance and breast cancer.
… or activation of cell signalling pathways. In MCF-10A breast epithelial cells, cell proliferation increased after insulin treatment by 180%. IR-phosphorylation, AKT-phosphorylation and ERK1/2 phosphorylation were all significantly increased while early apoptosis decreased after insulin …
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Characterisation of Small Ubiquitin-like Modifier (SUMO) protein complex expression in human cancer cells to identify novel therapeutic targets
… in NMR brain and intestine tissues compared to MCF-7, DLD-1, SH-SY5Y, and MCF-10A cells. Western blotting analysis also revealed high protein expression of PIAS4 in NMR compared to SENP1 and Ubc9. SUMO machinery expression levels from NMR are recapitulated in cancer cells either by silencing …
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Characterisation of Small Ubiquitin-like Modifier (SUMO) protein complex expression in human cancer cells to identify novel therapeutic targets
… in NMR brain and intestine tissues compared to MCF-7, DLD-1, SH-SY5Y, and MCF-10A cells. Western blotting analysis also revealed high protein expression of PIAS4 in NMR compared to SENP1 and Ubc9. SUMO machinery expression levels from NMR are recapitulated in cancer cells either by silencing …
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Phytochemicals from Graviola fruit selectively inhibit breast cancer cells growth involving EGFR signaling pathway
… did not affect non-transformed breast epithelial MCF-10A cells. GFE treatment was very effective against the growth of MDA-MB-468 BC cells with an IC50 of 4.8 µg/ml. In vitro, effects of GFE treatment on MDA-MB-468 BC cells were further examined for apoptosis and cell proliferation. Apoptosis, …
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Design, Synthesis, and Evaluation of a Novel Cytotoxic Peptide-Doxorubicin Conjugate Targeting Triple-Negative Breast Cancer
… toxic toward the non-cancerous breast cells, MCF-10A, compared to the free doxorubicin. Furthermore, results from evaluating surface expression levels of keratin 1 (K1) in different breast cancer cell lines and a normal breast cell line using immunohistochemistry staining suggested that …
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Global characterization of oncogenic kinase signaling
… active Src on the expressed kinome in MCF-10A cells was characterized using the optimized MS-based kinome profiling technique. In total, 302 kinases and 1,553 phosphorylation sites were identified. Applying a cut-off of ≥ 1.5-fold change unveiled a complex network comprised of 67 kinase …
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Novel bisnaphthalimidopropyl polyamine derivatives: their mode of action in a breast cancer cell system.
… breast cancer MDA-MB-231 and breast epithelial MCF-10A cells. Initially, work focused on determining the DNA binding affinities and biological activity of BNIPP derivatives. All BNIPP derivatives, except bisphthalimidopropyl diaminodecane (BPHPDadec) and mononaphthalimidopropylamine (NPA) (Delta …
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