Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"MCC950"”.
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Role of the NLRP3 Inflammasome in bacterial keratitis
… were investigated in the current study using MCC950, an NLRP3 inflammasome inhibitor in a mouse model of bacterial keratitis. Methods: The eyes of 7-10 weeks old female BALB/c were infected with strains of P. aeruginosa (6294, PAO1, 6206 and ATCC 19660) and S. aureus (31 and 38) and C57BL/6 …
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Exploring new regulators of innate immune signalling pathways with a particular focus on inflammasomes
… to the pharmacological inhibition of NLRP3 (with MCC950) and caspase (with<br/>z-VAD-FMK) activity. This study found that Kp activated the NLRP3 inflammasome, as well as other caspase-1/11-dependent and independent pathways that contributed to the production and secretion of IL-1β, but that these …
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Fatty Acid Regulation of NLRP3 Inflammasome Activity
… (PA) and the weak effect of the NLRP3 inhibitor MCC950, I found that this process requires not only the canonical inflammasome pathway but also the non-canonical inflammasome components caspase-4/5/11. Disruption of either pathway leads to partial impairments in the inflammasome response to PA, …