Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"MCAO"”.
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MCAO for Extremely Large Telescopes: the cases of LBT and E-ELT
Several MCAO systems are under study to improve the angular resolution of the current and of the future generation large ground-based telescopes (diameters in the 8-40 m range). The subject of this PhD Thesis is embedded in this context. Two MCAO systems, in dierent realization phases, are …
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Deficits in Auditory, Cognitive, and Motor Processing Following Reversible MCAO in Mice: Understanding the Human Stroke Phenotype
… to the brain. Middle cerebral artery occlusion (MCAO) can be induced in rodents, and is a widely used experimental technique to model focal ischemia in rodents. Various neurobehavioral tasks have been developed to assess the motor and cognitive dysfunctions associated with MCAO in rodents, and …
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The Role of Wnt3a in Ischemic Stroke
… through the Frizzled-1/PIWI1a/FOXM1 pathway in MCAO rats. 229 Sprague-Dawley rats were assigned to male, female, and aged 9-month male MCAO or sham groups followed by reperfusion 2 hours after MCAO. Animals assigned to MCAO were either given wnt3a or its control. To explore the downstream …
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Neurochemical Changes Following Stroke: Role In Neuroprotection And Cardiac Susceptibility
… following middle cerebral artery occlusion (MCAO) in adult male Wistar rats.;Five days following MCAO, the immunoreactivity for TH and neuropeptide Y (NPY) increased in the insular cortex (IC) within the peri-infarct zone. NPY also increased ipsilaterally in the basolateral nucleus of the …
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Analysis of Therapeutic Effect after Human Mesenchymal Stem Cell Transplantation in Ischemic Stroke Rat
… and physiological changes of hMSC-treated MCAo rat, I performed proteomic analysis of sham (n=3), tMCAo-only group (n=3) and hMSC-treated tMCAo rat group (n=3). Using 2-dimensinal electrophoresis (2-DE) and matrix-assisted laser desorption/ionization-time of flight-mass spectrometry …
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Evaluating Longitudinal Motor Recovery in Non-Human Primates after Middle Cerebral Artery Occlusion
… NHPs following Middle Cerebral Artery Occlusion (MCAO) by assessing performance with both NHPSS and Kinarm. Additionally, magnetic resonance imaging (MRI) will be used to confirm stroke morphology, and volume, and examine its relationship with functional recovery. Methods: Two cynomolgus macaques …
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Study on preparation of high performance CaO-MgO-Al2O3-SiO2 system glass-ceramic with industrial by-products
… heating them to melt. Different binary basicity (MCaO /MSiO<sub>2</sub> ) and content of Al<sub>2</sub>O<sub>3</sub> had been studied to determine the best formula for high performance glass-ceramic in terms of mechanical properties. Sample 04 (MCaO /MSiO<sub>2</sub> =0.4, …
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Targeting autophagy for improving stem cell function in brain repair
… mouse model of middle cerebral artery occlusion (MCAO). Animals were split into 3 transplantation groups: vehicle control; MHP/shRNA Scramble control; and MHP/Atg7-KD; and stem cell functionality in the ischaemic brain was measured using functional behavioural testing by the ladder crossing test. …
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The Effects of Onion and Yuzu Extracts against Ischemia/Hypoxia-Induced Dysfunction of Blood-Brain Barrier
… the mouse middle cerebral artery occlusion (MCAO) model and hypoxia model. The possible underlying mechanisms are also investigated, especially those linked to the oxidative stresses. Onion extract (OE) and its major component, quercetin (Quer), as well as yuzu extract (YE) and hesperidin …
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MAPK and pro-inflammatory mediators in the walls of brain blood vessels following cerebral ischemia
… infarct size after both permanent and transient MCAO, suggesting the involvement of TNF-α in neuronal cell damage [104]. In contrast, there is evidence to suggest that brain injury after ischemia becomes worse in mice lacking TNF-R1, suggesting that TNF-α mediates neuroprotection through this …
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Signal Transduction and Gene Regulation in Cerebral Arteries Following Ischemia
… expression. * Comparison of the ischemic models MCAO and SAH with organ culture of cerebral arteries to determine similarities and to validate the use of organ culture as a model. * Investigation of gene expression and protein regulation in human MCA following thromboembolic stroke so as validate …
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Towards a reproducible model for subcortical capsular strokes
… capsule is the middle cerebral artery occlusion (MCAO) model; however, this model is not a precise representation of stroke, causing large amounts of damage outside of the region on interest. Additionally, damage caused by the MCAO model can cause a variability in lesion sizes reducing its …
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Gelatin nanoparticles for improved neuroprotection of intranasally delivered osteopontin in ischemic stroke
… least 6 h post-middle cerebral artery occlusion (MCAO). Our findings support the development of GNPs as a promising drug delivery platform for the intranasal treatment of ischemic stroke and, potentially, other neurologic disorders.
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Development of intranasal therapeutic nanoparticles for the treatment of neurological disorders
… to 6 h after middle cerebral artery occlusion (MCAO) in a rat model. The specific properties of intranasal GNPs that confer these beneficial effects are poorly understood. Therefore, we sought to support the development of GNPs as a drug delivery platform for the IN treatment of ischemic stroke …
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Star Cluster Formation and Galactic Assembly: from instrumentation, to observations and simulations
… the future ESO, ANU-led instrument, MAVIS. The MCAO-assisted Visible Imager and Spectrograph (MAVIS) will have the spatial resolution required to re- solve crowded GC centres and the astrometric accuracy to measure the motions of the central stars. To assess if this is feasible, we created the …
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Star Cluster Formation and Galactic Assembly: from instrumentation, to observations and simulations
… the future ESO, ANU-led instrument, MAVIS. The MCAO-assisted Visible Imager and Spectrograph (MAVIS) will have the spatial resolution required to re- solve crowded GC centres and the astrometric accuracy to measure the motions of the central stars. To assess if this is feasible, we created the …
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Macroinvertebrate composition of the upper Georges River with reference to urban, industrial and agricultural impacts
… Axis Correlation (PCC) and Monte-Carlo sampling (MCAO) in PATN. The data were fourth root transformed and a Bray-Curtis Dissimilarity Matrix was used in MOS. The reference sites had the lowest abundance for five of six surveys for the pool habitat and all surveys for the edge habitat. The highest …
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INVESTIGATION OF GENETIC FACTORS DETERMINING ISCHEMIC STROKE OUTCOME
… model is the middle cerebral artery occlusion (MCAO) model. First, we screened infarct volumes across 32 inbred mouse strains. The infarct volume varies between strains, and this strongly suggests that infarct volume is genetically determined. To identify these genetic factors, we used …
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The Gut Microbiome as a Novel Approach for Reversing Long-Term Inflammation and Accelerated Aging Across the Lifespan
… modeled using middle cerebral artery occlusion (MCAO). Inflammation was characterized by flow cytometry and transcriptomics (NanoString). 16S rRNA sequencing was used for bacterial analysis of fecal samples and validating successful fecal microbiota transplantation (FMT). Mass spectrometry …
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Ischemic Stroke Damage Is Reduced By Inhibition of Il-6 Signaling With to cilizumab
… right middle cerebral artery occlusion (MCAO) {6} under isoflurane anesthesia followed by reperfusion and then studied for 35 days<strong>.</strong><strong> </strong>Four hours after the onset of ischemia, mice were given an intraperitoneal injection of either tocilizumab (20mg/1kg) or an …
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