Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"MCAK"”.
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Mechanistic Insights into the Microtubule-Mediated Differential Modulations of Aurora B Substrate Structures for Accurate Chromosome Segregation
… examined mitotic centromere-associated kinesin (MCAK), a microtubule depolymerase whose activity is suppressed by Aurora B phosphorylation to stabilize spindle microtubules. Using the same cryo-EM pipeline, I resolved the structure of microtubule-bound MCAK and found that the key Aurora B …
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RNA localizations of proteins that interact with the chromosome passenger complex
… Xist. An RNAi screen was used to identify that MCAK, a known target of AURKB’s kinase activity, is another player in the dispersal of Xist. Our results also demonstrated that nuclear envelope breakdown precedes the release of ncRNAs into the cytoplasm, and that MCAK knockdown delays the …
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Control of Chromosome Segregation by the Aurora B Complex
… of the microtubule-depolymerizing kinesin MCAK, whose activity is negatively regulated by Aurora B. We demonstrate that the Aurora B pathway is normally suppressed in the cytosol, but becomes activated by chromatin and centrosomes, leading to the phosphorylation of both histone H3 and the …
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Constitutively active-RSK2 induces chromosomal instability through diverse mechanisms
… we observed that the co-transfection of RSK2 and MCAK decreased lagging chromosome and chromosome bridge during anaphase, indicating that enhancement of kinetochore microtubule stability was indeed the cause of CIN in these cells. Taken together, constitutively active RSK2 induced chromosomal …
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Changes in Kinetochore Structure and Molecular Composition in Response to Mis-attachment
… chromosomes, may play a key role in bringing MCAK and other KT substrates closer to Aurora B kinase for rapid and efficient correction of KT mis-attachments.
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Functional gene analysis in cultured vertebrate cells using siRNA mediated gene silencing
… separase) und Kinesin verwandte Motorproteine (MCAK, TPX2, HSET, KIA0622).Die Zinkfinger Metallprotease prozessiert das Zellkernprotein prelamin A durch endoproteolytische Entfernung der carboxyterminalen 16 Aminosäuren zu reifem lamin A. Die Unterdrückung dieser proteolytischen Spaltung des …
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Mitotic slippage by ATP depletion and its mechanism
… checkpoint proteins including BubR1, Mad2, and MCAK. However, the localization and the kinase activity of Aurora B, which is widely recognized as a component of error correction of microtubule attachment and its role in maintenance of spindle assembly checkpoint, were reduced on kinetochores …
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Theoretical aspects of motor protein induced filament depolymerisation
Many active processes in cells are driven by highly specialised motor proteins, which interact with the cytoskeleton: a network of filamentous structures, e.~g.~ actin filaments and microtubules, which organises intracellular transport and largely determines the cell shape. These motor proteins are …