Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"MC5R"”.
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Analyzing the Interactions Between Xenopus tropicalis MC2R, MC5R, and the MRAPs: Modeling the Regulation of Frog Interrenal Cells
… receptor accessory proteins are expressed: MC2R, MC5R, MRAP, and MRAP2. The MRAPs have an opposite effect on the cell surface expression of MC2R and MC5R. In mammals, MRAP aids MC2R but inhibits MC5R cell surface expression. This thesis aims to explore the functional relationship between MC2R, …
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Investigating lymphocyte development in the foetal thymus and modulation by the melanocortin 5 receptor
… bulk RNAseq gene expression data, I identified Mc5r, encoding the fifth melanocortin receptor (Mc5r), as expressed more highly by ILC2 than ILC3. Treatment of mice with the neuropeptide alpha-melanocortin-stimulating hormone (αMSH), an agonist for melanocortin receptors, induced increases in the …
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The Impact of Melanocortin Receptor Ligands on Astrocyte Signalling and Metabolism
… comprising a family of five subtypes (MC1R to MC5R), are 7-transmembrane receptors that can couple with G proteins or function independently of them. These receptors are present in the central nervous system (CNS) as well as other body tissues. This thesis concentrates on the role of MCRs …
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The Multifunctional Melanocortin System in the Human Choroid
… activates melanocortin receptors (MC1R to MC5R) and receptor accessory proteins (MRAPs), forming the melanocortin system. α-MSH can also reduce UV-induced oxidative stress in skin melanocytes and potentially downregulate inflammation, facilitate DNA repair, stabilise damaged DNA and prevent …
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Analyzing the Interaction Between Melanocortin 5 Receptor, Melanocortin Receptor Accessory Protein 1, and Melanocortin 2 Receptor in Rainbow Trout
… relationship of rainbow trout MC5 receptor (rtMC5R) with zebrafish MRAP1 (zfMRAP1) and rainbow trout MC2 receptor (rtMC2R), as well as how the effect of such relationships may play a significant role in Hypothalamic-Pituitary-Adrenal/Interrenal axis activation. This research demonstrated that …