Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"MC3R"”.
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Hypothalamic control of energy rheostasis during metabolic challenges, pregnancy, and lactation
… fully understood. The melanocortin-3 receptor (MC3R) has been shown to play an important role in energy rheostasis, with global constitutive MC3R deletion of the gene impairing behavioral responses to both orexigenic and anorexic challenges. To identify the specific brain regions and mechanisms …
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Novel pathways of human host defence against Mycobacterium tuberculosis
… the role of the Melanocortin 3 Receptor (MC3R) in macrophages with mycobacterial infection, finding support for a critical role of this receptor in host restriction of Mtb: deletion of MC3R in macrophages resulted in increased Mtb survival; increasing MC3R activity using synthetic …
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Exercise-induced alterations in melanocortin receptor expression and inflammation
… 1 receptor (MC1R) and melanocortin 3 receptor (MC3R) are expressed on immune cell populations. Several lines of in vitro research have shown that activation of the MC3R on cultured macrophages leads to pregulation of the anti-inflammatory pathways, suggesting a novel role for MCRs in mediating …
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Genetic and molecular characterisation of metabolic subphenotypes and their contribution to type 2 diabetes aetiology
… and genetic investigation of a single gene, MC3R, of which loss of function was previously thought to result in obesity and metabolic dysfunction, revealed that this was not the case. Combining functional assessment of coding variants in MC3R and association analyses at population-scale …
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From genomics to function: Canine genetics highlight novel mechanisms of obesity and related traits
… canine MCR genes in obesity. Missense variants MC3R p.M320I and MC4R p.V213F were detected at varying frequencies across the breed groups. The loss-of-function mutation, MC3R p.M320I, was common in Labrador retrievers. Carrying the mutation was associated with delayed onset of puberty and a …
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Hypothalamic Regulation of Food Intake in Obese and Anorexic Avian Models
… neuropeptide S, melanocortin receptor 3 (MC3R), and mesotocin. The gene expression data from individual hypothalamic nuclei revealed that mesotocin from the PVN may play an important role in the inhibition of appetite in the LWS. Experiment 3 was then designed to evaluate the effects of …
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The Impact of Melanocortin Receptor Ligands on Astrocyte Signalling and Metabolism
… ion buffering, and metabolic activities. While MC3R and MC4R were initially considered the main MCR subtypes expressed in CNS neurons, recent evidence suggests that other MCR subtypes may also be present, although their expression and function in astrocytes remain poorly defined. This thesis …
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Mapping the Feeding Circuitry in the Mouse and Human Brain
… of POMC neurons, and neurons expressing the MC3R and MC4R. Using the mouse and human hypothalamic atlases, we identify and characterise GLP-1R expressing populations, describing similarities and differences between the mouse and human. We confirm co-expression of *GLP1R* with key transcripts …
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Genetic Determinants of Body Weight and Physical Maturation Across the Life Course
… variants impact puberty timing (KDM4C, MC3R, MKRN3, PDE10A, TACR3, ZNF483) by performing an exome-wide association study on recalled age at menarche (N~220,000) and age at voice breaking (N~180,000) in the UK Biobank. To better understand which biological factors influence puberty …