Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 16 of 16 for “"MC1R"”.
-
Erfðabreytileiki í MC1R geninu í muskóttum (glóbrúnum) íslenskum hrossum
… er að hafi áhrif er E-sæti, þar sem að genið MC1R stýrir litarefnamyndun ýmist í átt að svörtu eða brúnu eumelanín eða rauðu, gulu eða appelsínugulu feómelanín. Tvær meginsamsætur finnast í E-sæti í hrossum. Önnur þeirra er villigerðin E+ sem er ríkjandi og eykur myndun eumelaníns, hin er …
-
Podocyte Melanocortin 1 Receptor Mediated Signaling
… glomerulus. Thus, the melanocortin 1 receptor (MC1R) was found to be colocalizing with the podocyte marker synaptopodin. Treatment with MC1R specific agonists had beneficial effects in an experimental model of membranous nephropathy, Passive Heymann Nephritis (PHN). The aims of this thesis have …
-
Regiões genómicas associadas à variação da coloração da pelagem em bovinos da raça GIR
… coat phenotype and perform fine mapping of the MC1R gene, a gene that has already been reported to affect the coat in other cattle breeds. A total of 574 Gir animals were genotyped with a commercial Zoetis low-density chip of 29,842 SNPs were used in nine genomic wide association (GWAS) …
-
The evolutionary genetics of sexually selected plumage colour traits in the galliform birds
… evidence for sexual selection acting at the MC1R locus, in the form of a robust correlation between dN/dS and sexual plumage dichromatism that was not found at any of the other loci. I then went on to investigate the evolution and population genetics of MC1R in the grouse, focusing on the …
-
The Multifunctional Melanocortin System in the Human Choroid
… mediated by melanocortin ligand-receptor (α-MSH/MC1R) signalling. The neuropeptide alpha-melanocyte stimulating hormone (α-MSH) activates melanocortin receptors (MC1R to MC5R) and receptor accessory proteins (MRAPs), forming the melanocortin system. α-MSH can also reduce UV-induced oxidative …
-
Exercise-induced alterations in melanocortin receptor expression and inflammation
… exercise training. The melanocortin 1 receptor (MC1R) and melanocortin 3 receptor (MC3R) are expressed on immune cell populations. Several lines of in vitro research have shown that activation of the MC3R on cultured macrophages leads to pregulation of the anti-inflammatory pathways, suggesting a …
-
Sequence Analysis of PMEL17 as Candidate Gene for Causing Rat-Tail Syndrome in Cattle
… the rat-tail phenotype, the "extension locus" (MC1R) and an unknown locus. In order to express the rat-tail phenotype the animal must inherit at least one black allele at MC1R and be heterozygous at the unknown locus. The rat-tail locus was previously mapped to an 8.7 cM region of Bos Taurus …
-
Investigation of in-situ nanoimprinting of cell surface receptors: potential of a novel technique in biomarker research
… the technique, we used melanocortin receptor 1 (MC1R), a receptor present at high levels on the surface of melanoma cells, as a test system. We determined optimum binding of this molecule in an established melanoma cell line, WM-266-4. We also synthesized a labeled molecule that was used to …
-
Mapping phenotypic traits in swine
… chromosome 6 contained melanocortin receptor 1 (MC1R), a gene known to control pigmentation in mammals. Each animal in the population was genotyped for the MC1R recessive e/MC1R*4 allele (A240T mutation), and all white F2 animals genotyped as homozygous 240T, or e/e. Tyrosine hydroxylase was …
-
Genomic characterization of the italian wolf (Canis lupus): the genes involved in black coat colour determination and application of microarray technique for snps detection.
… protein acts as an alternative ligand for the Mc1r. This research project was conducted in collaboration with Prof. Gregory Barsh, Department of Genetics and Paediatrics, Stanford University. On the other hand, we performed analysis on a high number of SNPs thanks to a customized Canine …
-
The genetic basis of plumage polymorphism in the black sparrowhawk
… the melanogenesis genes melanocortin 1 receptor (MC1R), agouti signalling protein (ASIP), or proopiomelanocortin (POMC). However, the expression levels of several genes involved in melanogenesis differed between the two morphs, with light morph developing breast feathers showing significantly …
-
Erfðabreytileiki í ASIP geninu í íslensku sauðfé
… Þekkt er að ASIP genið á í samspili við genið MC1R og að samsætur hvors gens um sig geti verið í yfirstöðu yfir hinu. Loks eru teikn á lofti um fjölvirkni ASIP gensins, en það er talið geta tengst bæði lita- og atferlisbreytileika. Til að varpa ljósi á breytileika í táknröðum ASIP gensins voru …
-
The Impact of Melanocortin Receptor Ligands on Astrocyte Signalling and Metabolism
… MCRs, comprising a family of five subtypes (MC1R to MC5R), are 7-transmembrane receptors that can couple with G proteins or function independently of them. These receptors are present in the central nervous system (CNS) as well as other body tissues. This thesis concentrates on the role of …
-
Development of inducible transgenic mouse models for melanoma
… not on Ras signalling pathway, e.g. MC1R pathways) would provide an up-to-date, superior mouse model able to mimic molecular aetiology of human melanoma to investigate the functions and mechanisms of other genes such as MITF, B-Raf, MC1R etc involved in the development of human …
-
Molecular Signatures of Adaptation: MHC Evolution and Natural Selection in European Rabbits
… by an allele containing a 30-bp deletion in the MC1R gene that was introgressed from domestic rabbits, while alleles with no deletion encode grey phenotype. Analysis of rabbit remains from eagle nests showed a significant underrepresentation of ginger phenotypes compared to the field …
-
Entwicklung neuer Markersysteme für die ancient DNA Analyse
Die Rekonstruktion der Lebensbedingungen von Menschen vergangener Zeiträume ist eines der Desiderate der Prähistorischen Anthropologie. Ein wichtiges Quellenmaterial stellen in diesem Zusammenhang die körperlichen Überreste vor- und frühgeschichtlicher Menschen dar. Ihre Analyse bietet Zugang zu …