Global ETD Search
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Showing 1 to 5 of 5 for “"MC160"”.
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Characterization of the Anti-Inflammatory Effects of the Molluscum Contagiosum Virus MC160 Protein
Using a series of MC160 deletion mutant proteins, we found that two distinct regions of the MC160 protein independently inhibit TNF-mediated NF-kappaB activation. Specifically, we observed that the second DED of MC160 interacts with procaspase-8 as a means to inhibit NF-kappaB activation, while the …
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Functional Analysis of the Molluscum Contagiosum Virus MC160 Death Effector Domain-Containing Protein RxDL Motif
… domain (DED) containing proteins, MC159 and MC160. DEDs are found in cellular proteins such as FADD and procaspase-8. These cellular proteins are involved in several innate immune responses such as apoptosis and activation of interferon (IFN). Presumably, MC159 and MC160 bind to host …
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Finding NEMO by the molluscum contagiosum virus MC159 protein and its effect on viral pathogenesis in vivo
… IV). The importance of MC159 and its homolog MC160 during MCV infection has remained unknown, as there is no standard tissue culture for propagation or an animal model of infection. All of the functions of MC159 and MC160 were identified by expressing MC159 independent of infection. To bridge …
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Characterization of a Mitochondrial Localizing Molluscum Contagiosum Virus Protein: MC163R
… viral growth. MCV IEMs alter apoptosis (MC159, MC160), deregulate the cell cycle targeting retinoblastoma (MC007), and produce a chemokine homolog (MC148). Bioinformatics analysis identified MC163, as another potential host-interacting protein. Further analysis of MC163 resulted in the …
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Characterization of the anti-inflammatory effects of the Molluscum Contagiosum MC159 protein
… Finally, I show homologs of MC159 including MCV MC160 and cellular FLIPL, inhibit IFN-β expression, suggesting DEDs are important for regulation of IFN-β responses.