Global ETD Search
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Showing 1 to 4 of 4 for “"MC159"”.
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Characterization of the anti-inflammatory effects of the Molluscum Contagiosum MC159 protein
… encodes immunomodulatory proteins such as the MC159 protein to combat the effects of TNF-α and IFN-β. The work presented here details MC159 mediated inhibition of these cytokines through the NF-κΒ and IRF-3 transcription factors. TNF-α is a critical initiator of the pro-inflammatory response …
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Finding NEMO by the molluscum contagiosum virus MC159 protein and its effect on viral pathogenesis in vivo
… MCV encodes immunomodulatory proteins like MC159 protein to antagonize/neutralize TNF and other aspects of the proinflammatory immune response. For example, the MCV MC159 protein suppresses NF-kB activation, a powerful anti-viral response, via interactions with the NEMO subunit of the IKK …
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Functional Analysis of the Molluscum Contagiosum Virus MC160 Death Effector Domain-Containing Protein RxDL Motif
… death effector domain (DED) containing proteins, MC159 and MC160. DEDs are found in cellular proteins such as FADD and procaspase-8. These cellular proteins are involved in several innate immune responses such as apoptosis and activation of interferon (IFN). Presumably, MC159 and MC160 bind to …
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Characterization of a Mitochondrial Localizing Molluscum Contagiosum Virus Protein: MC163R
… cell for viral growth. MCV IEMs alter apoptosis (MC159, MC160), deregulate the cell cycle targeting retinoblastoma (MC007), and produce a chemokine homolog (MC148). Bioinformatics analysis identified MC163, as another potential host-interacting protein. Further analysis of MC163 resulted in the …