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Showing 1 to 8 of 8 for “"MBNL"”.

  1. Oddziaływania RNA z białkami MBNL – podstawy strukturalne, potencjalne inhibitory oraz implikacje funkcjonalne

    Taylor, Katarzyna2017

    amu-pl

  2. Development of therapeutic agents for myotonic dystrophy type 1

    Li, KeUniversity of Illinois at Urbana-Champaign2021

    … structures sequester the muscleblind-like (MBNL) family of proteins. MBNL proteins are responsible for post-transcriptional splicing and polyadenylation site regulation. The sequestration of MBNL proteins prevents them from performing their proper function, leading to hundreds of splicing …

    uiuc Repository record

  3. Natural Language Human-Computer Dialogue: Menu-Based Natural Language and Visual Performance

    Hendrickson, Jeffrey John2019

    … principles for menu-based natural language (MBNL) interfaces and to provide evidence for the nature of visual search processes with menu-based systems. The effects of window size, window activity, and query length were investigated. Window size was manipulated as a between-subjects variable …

    odu Repository record

  4. Alternative isoform regulation in myotonic dystrophy

    Wang, Eric T. (Eric Tzy-shi)Massachusetts Institute of Technology2012

    … in DM, focusing on the Muscleblind-like (MBNL) family of RNA binding proteins, which are functionally inactivated by CUG or CCUG repeats. Using RNAseq to profile tissues and cells depleted of MBNLs, we found that MBNL1 and MBNL2 co-regulate hundreds of redundant targets. MBNL1 UV …

    mit Repository record

  5. Exploring the functional conservation of muscleblind (Mbl) proteins

    Oddo, Julia C. (Julia Christine)Massachusetts Institute of Technology2015

    … elegans were compared to human Muscleblind-like (MBNL). The zinc finger RNA-binding domains are the most conserved region between homologs, suggesting a conserved role in RNA binding and splicing regulation. To test this, we used splicing reporter assays with validated human MBNL-regulated …

    mit Repository record

  6. Design, synthesis, and biological activities of small molecules that target myotonic dystrophy

    Nguyen, Lien Thi ThuyUniversity of Illinois at Urbana-Champaign2016

    … The sequestration of muscleblind-like proteins (MBNL) by CUGexp or CCUGexp causes splicing defects in more than 100 pre-mRNAs, resulting in various disease phenotypes. As such, therapeutic development for DM has mainly focused on agents targeting the CUGexp/CCUGexp -MBNL1 interaction. This …

    uiuc Repository record

  7. RNA recognition: controlling RNA-protein complexes with small molecules

    Ramisetty, Sreenivasa RaoUniversity of Illinois at Urbana-Champaign2010

    … the Interaction of Pathogenic RNAs with the MBNL1 Protein and Complex Inhibition by Small Molecules PART I. RNA plays important and versatile roles in gene expression by both carrying and regulating the information used to direct protein synthesis. Therefore, small molecules able to bind to …

    uiuc Repository record

  8. Studying Tissue Specific Diversity of Splicing Regulator Muscleblind

    Hanley, Davron2022

    <p>The muscleblind (mbl) family of RNA-binding proteins regulates alternative splicing, determining mRNA transcript composition for various types of tissue, and has been implicated in myotonic dystrophy. The mbl gene is subject to alternative splicing in Drosophila, leading to multiple isoforms, …

    kennesaw Repository record