Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"MBD4"”.
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Determination of an interaction between the DNA repair proteins MLH1 and sMBD4 and aspirin regulation of DNA repair gene and protein expression in colorectal cancer
The base excision repair protein, MBD4 (also known as MED1) is known to be transcriptionally coupled to a mismatch repair protein MLH1. To date the significance of this coupling has not been elucidated and the significance of MBD4 within the mismatch repair system and apoptotic pathway is still …
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Defensins In Ocular Immunity
… (mBD1 and mBD2) or</p> <p>inducible (mBD3 and mBD4) in normal BALB/c and B6 corneas, and disparately</p> <p>regulated in BALB/c vs B6 corneas after infection. Knock down studies using siRNA</p> <p>treatment indicated that mBD2 and mBD3, but neither mBD1 nor mBD4, is required in</p> <p>ocular …
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Role of inherited DNA repair deficiencies in cancer susceptibility and evolution
… the base excision repair (BER) genes MUTYH and MBD4, which are associated with colorectal cancer, among other cancer types. The impact of heterozygous variants in BER pathway components is widely debated due to mixed evidence. My analyses utilising germline and somatic data from large publicly …
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DNA Damage Response in Huntington’s Disease and Naked Mole Rat Brain Ageing
… potential modifiers of CAG expansion such as MBD4, PMS2, and RNASEH2A. Several hits from this arrayed CRISPR screen for modifiers of CAG repeat expansion converged on the regulation of R-loops, suggesting that these DNA-RNA hybrid structures may contribute to CAG repeat instability and genomic …
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Methylated DNA detection using a high-affinity methyl-CpG binding protein and photopolymerization-based amplification
… three of the core members MBD1, MBD2, and MBD4 on the surface of Saccharomyces cerevisiae yeast cells. Using the yeast display platform, I determined the equilibrium dissociation constant of human MBD2 (hMBD2) to be 5.9+/-1.3 nM for binding to singly methylated DNA. I further used the yeast …
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Maintaining Proper Levels of DNA Methylation Marks Through the TET Family is Critical for Normal Embryo Development in Pigs
… in embryos. Cloning of porcine MBD1, MBD3, and MBD4 from mature oocytes indicates that the genes are highly conserved among different species, implying the involvement of porcine MBD proteins in the maintenance of DNA methylation. MBD1 overexpression in oocytes impaired preimplantation …