Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 130 for “"MAbs"”.
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Radioimmunotherapy of Metastatic Disease - Studies of Alpha- and Beta-particle-Emitting Radionuclides in a Preclinical Model
In radioimmunotherapy, monoclonal antibodies (mAbs) are used as a targeting agent carrying a toxic payload consisting of radionuclides. This treatment allows the irradiation of small lesions, even on the microscopic level. In the present work, two radionuclides with different properties were used. …
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Chimeric ANTI-CD19 Monoclonal Antibodies for the Treatment of Precursor B Cell Acute Lymphoblastic Leukemia
… are based on anti-CD20 monoclonal antibodies (MAbs). However, CD20 is not expressed on precursor B cell acute lymphoblastic leukemia (pre-B ALL), and CD20 expression is often lost following anti-CD20 immunotherapy. CD19 is a pan B cell membrane antigen that is restricted to the B cell lineage …
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Structure-function of Dengue 2 virus envelope protein domain III with neutralizing antibodies
… ED3-specific neutralizing monoclonal antibodies (MAbs). Site-directed mutagenesis of a DENV-2 recombinant ED3 (rED3) was done in order to map functionally important residues for binding of a panel of 13 ED3-specific MAbs. Seven of these MAbs were DENV-2 type-specific and recognized a single …
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A fragment-based approach towards understanding molecular recognition of 4’-phosphopantetheine adenylyltransferase from Mycobacterium abscessus
… (PPAT) from Mycobacterium abscessus (Mabs). A fragment screen of the Abell laboratory 960-member library was conducted by Dr Sherine Thomas (Department of Biochemistry, University of Cambridge) and identified 15 hits validated by X-ray crystallography. The structural information …
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Personal Debt, Poverty and Public Policy in Ireland. The Impact of the Money Advice and Budgeting Service on Over-indebtedness among those in Poverty
… namely the Money Advice and Budgeting Service (MABS). The main objectives of MABS are to enable people to cope with their immediate debt problems and become financially independent in the long term and to this end, MABS works closely with the Irish credit union movement. There has been no …
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"A fish out of water": The middle-class experience of over-indebtedness and the role of adult education.
… with the Money Advice and Budgeting Service (MABS), I noticed a new cohort of clientele seeking the advice of MABS. Traditionally the MABS client base was confined to those from disadvantaged backgrounds but this new cohort are educated and middle-class. They present to the service in states …
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Dynamics and Phase Behavior of Mixed Antibody-Excipient Adsorption at an Air/Water Interface
<p>Monoclonal antibodies (mAbs) have become a leading candidate for oncological therapeutics due to their unparalleled selectivity. Monoclonal antibodies are amphiphilic, containing polar and nonpolar amino acid residues on their biomolecular surfaces. Their amphiphilic nature drives mAbs to …
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UNDERSTANDING THE MOLECULAR BASIS OF CELL DEATH MEDIATED BY ONCOSIS-INDUCING CYTOTOXIC ANTIBODIES
MONOCLONAL ANTIBODIES (MABS) A2, B3 AND B8, RAISED AGAINST HUMAN EMBRYONIC STEM CELLS, WERE FOUND TO SPECIFICALLY INDUCE ONCOSIS IN VARIOUS CANCER CELL LINES BUT NOT TO CORRESPONDING NORMAL CELL LINES. CHARACTERIZATION REVEALED THAT THESE MABS RECOGNIZED A GLYCAN MOIETY STRUCTURALLY RELATED TO …
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Investigation of preferential binding properties of monoclonal antibodies M1:1D2 and H4:4 towards the conformers of recombinant prion protein
… prion diseases in live animals or humans. Use of mAbs will certainly increase sensitivity of diagnosis and it may also allow detection of PrPSc in body fluids. In this project the two mAbs M1:1D2 (IgG3) and H4:4 (IgG2a) which were raised against prion protein purified from outdated human platelets …
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Development and Characterization of Monoclonal Antisperm Antibodies: Potential for Contraception
… sperm membrane-specific monoclonal antibodies (MAbs) were developed. When these antisperm MAbs were subjected to evaluation against an extensive panel of human tissues, no cross-reactivity to somatic tissues was observed, but staining was seen on sperm cells in testis, caput- and cauda …
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Producción de anticuerpos monoclonales que reconozcan proteínas de membrana en células de memoria en aotus spp
… Entre los anticuerpos monoclonales comerciales (mAbs) para los marcadores moleculares de células T de memoria CD19 +, CD27 + B y CD4 +, CD45RO +, solo los del clon SK3 reconocieron las células T Aotus CD4. En este trabajo, los enfoques bioinformáticos fueron usados para diseñar péptidos …
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Antigenic Characterization of <I>Haemophilus somnus</I> Lipooligosaccharide
… must be increased. Monoclonal antibodies (MAbs) to <I>H. somnus</I> LOS were produced and used with cross-reacting MAbs to <I>H. aegyptius</I> LOS (MAb 5F5) and <I>Neisseria</I> <I>gonorrhoeae</I> LOS (MAb 3F11) in an ELISA to investigate LOS heterogeneity among forty-five strains of <I>H. …
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NOVEL MONO-, BI- AND TRI-SPECIFIC IMMUNOMODULATORY ANTIBODIES FOR CANCER THERAPY AND TOOLS FOR OTHER THERAPEUTIC AND DIAGNOSTIC APPLICATIONS
… with clinically validated monoclonal antibodies (mAbs). Interestingly, the combination of novel human PD-L1_1 (anti-PD-L1 mAb) and ID-1 (anti-CTLA-4 mAb) induced efficient lysis of triple-negative breast cancer cells and lower cytotoxicity on cardiomyocytes, when co-cultured with lymphocytes, …
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Cd44-Hyaluronic Acid Interactions in Il-2 Induced Vascular Leak Syndrome
… In the current study we tested whether use of mAbs against CD44 or hyaluronic acid (HA), the ligand for CD44, can abrogate IL-2 induced VLS. Administration of IL-2 (75,000 U/mouse, three times a day for 4 days) into C57BL/6 mice triggered significant VLS in the lungs and liver. Interestingly, …
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DEVELOPMENT AND CHARACTERIZATION OF NOVEL MONOCLONAL ANTIBODIES TARGETING CARBOHYDRATE ANTIGENS IN CANCER
… and Milstein in 1975, monoclonal antibodies (mAbs) have quickly become a key component in the select targeting, blocking and clearance of many diseases by the immune system. Today mAbs constitute the fastest growing segment of immunotherapy in the diagnosis and treatment of cancer. These …
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Understanding the Mechanism of Action of Rituximab in the Reversal of Multidrug Resistance in a Non-Hodgkins Lymphoma Cell Line
… unknown. A recent study showed that anti-CD20 MAbs could induce rapid redistribution of CD20 into a detergent-insoluble embrane compartment (lipid rafts). By redistributing CD20 into rafts, Rituximab(tm) (RTX) modified their stability and organization. P-glycoprotein (P-gp) is the constituent …
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H4:1 and H4:2 monoclonal antibodies discriminate between the normal and misfolded conformers of recombinant prion protein
… proteinase treatment step. There are very few mAbs available in the market which do not require the PK step. In this project we tested two mAbs H4:1 and H4:2 which are selective against synthetic peptide made by the SDS method. Even the peptide made by this method is unglycosilated these mAbs …
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Characterization, Stabilization and Formulation Design of IgG and Secretory IgA Monoclonal Antibody Candidates during Storage and Administration
ABSTRACT Monoclonal antibodies (mAbs) have become a class of therapeutic protein-based drugs of high importance for treating numerous human diseases. As a complex, delicate three dimensional molecule, a mAb can be sensitive to ambient environments and thus often display colloidal/conformational …
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Self-Assembling Bioaffinity Hydrogels for Localized Antibody Delivery
… are being treated using monoclonal antibodies (mAbs) has been expanding from cancers to autoimmune diseases due to their high specificity to their molecular target. Because many of the new mAbs are aimed to modulate the immune system, an emerging concern is that patients with chronic illnesses …
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