Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"MAT2A"”.
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SAM Homeostasis Is Regulated by CFIm-Mediated Splicing of MAT2A
… SAM levels through intron detention of MAT2A, the only SAM synthetase expressed in most cells. The N6-adenosine methyltransferase METTL16 promotes splicing of the MAT2A detained intron by an unknown mechanism. Using an unbiased CRISPR knock-out screen, we identified CFIm25 (NUDT21) as a …
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Therapeutic Potential of Prmt5 and Mat2A As Synthetic Lethal Targets In Mtap-Deficient Gbm Tumors
… making these cells sensitive to PRMT5 and MAT2A inhibition. Although elevated levels of MTA <em>in vitro</em> define a promising actionable metabolic vulnerability, the clinical relevance relies on exhibiting significant MTA accumulation in human tumors. Here, we demonstrate that, unlike …
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Investigating the mechanisms of BK Polyomavirus egress and virus-host interactions.
… discovery of S-adenosylmethionine transferase MAT2A as a potentially important factor in early viral life cycle progression. The results presented here reveal that deletion of MAT2A results in the reduction of infected cell number and several early viral life cycle phenotypes. The mechanism …
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Rational drug combinations to selectively target 9p21-deleted bladder cancer
… several cancer types and identified PRMT5 and MAT2A as synthetic lethal interactions in this context. Consequently, PRMT5 (MRTX1719) and MAT2A (AG270) inhibitors have been developed and are currently being tested in clinical trials to treat MTAP-deleted tumors. Here, we performed a …
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Structures and Regulation of the N6-Methyladenosine Methyltransferase METTL16
… activity of METTL16 on the SAM synthetase gene, MAT2A, modulates SAM homeostasis, implicating METTL16 as a global regulator of methylation in the cell. Here, I present structural and biochemical data towards determining the specificity, function and regulation of both the METTL16 and …
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THE METHIONINE CYCLE AS A NOVEL THERAPEUTIC TARGET IN NPM1C DRIVEN ACUTE MYELOID LEUKEMIA
… of Methionine Adenosyltransferase 2A (MAT2A), the key enzyme that catalyzes SAM production, leading to SAM/SAH ratio unbalance; ii) the SAM/SAH ratio unbalancing; and iii) the sensitivity to SAM treatment. To explore alternative approaches to increase the SAM/SAH ratio, we used …