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Showing 1 to 20 of 52 for “"MAPKs"”.
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Nucleocytoplasmic Localization of MAPKs
Mitogen-activated protein kinases (MAPKs) comprise a family of protein-serine/threonine kinases, which participate in signal transduction pathways that control intracellular events. MAPKs are regulated by phosphorylation cascades, which are usually initiated by external stimuli including a variety …
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Role of phosphatases in controlling arabidopsis mapk signalling cascades
… conditions. Mitogen-activated protein kinases (MAPKs) constitute a highly conserved family of enzymes in eukaryotes, and in plants MAPK-based signal transduction modules regulate a large number of physiological processes, including responses to environmental stresses and phytohormones. Regulated …
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Substrate Interaction and Sub-Cellular Localization in Map Kinase Pathways
… are the mitogen-activated protein kinases (MAPKs). Among the various MAPKs identified, the extracellular signal-regulated kinases, ERK2 and ERK5 are two closely related enzymes that have overlapping functions in a number of cellular pathways. Sub-cellular localization and specificity towards …
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Characterization of theWound-Induced Signaling Pathway In Tomato
… the systemin-responsive MAPK cascade, including MAPKs, the putative systemin receptor, and MAPK Kinases. One of the initial signaling events after systemin perception involves ion fluxes that result in extracellular alkalinization; however, changes in the extracellular pH are neither sufficient …
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Identification of a mitogen-activated protein kinase, p56, which mediates the self-incompatibility response in Papaver rhoeas L.
… is involved in activation of PCD during SI. MAPKs have been shown to be important signalling components in a range of cellular responses in eukaryotes. In Arabidopsis thaliana there are 20 MAPKs with roles including cell division, abiotic stress response, wounding response and hormone …
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A study on the role of oxidative stress and protein kinase signalling in hyperglycaemia induced cardiac remodelling
… (MAPK). Although there are several different MAPKs, the p38 MAPKs are involved in cardiogenesis and implicated in stimulating myocyte apoptosis, hypertrophy, or even antiapoptotic effects. As such, the role of p38 MAPKs in diabetic cardiac remodelling, especially during cardiac development, …
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Regulation of transcription factors NRF2 and HSF1 in mediating cellular stress responses
… activates p38 mitogen-activated protein kinases (MAPKs). In vitro, all members of the p38 MAPK family rapidly and stoichiometrically catalyze the phosphorylation of HSF1 on S326, a hallmark of HSF1 activation. The use of stable knockdown cell lines and inhibitors indicated that among the p38 MAPK, …
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Assessing eIF4E-S209 Signaling and Translationally Regulated Mechanisms in Neurodegeneration
… protein kinase (MAPK) signaling cascades. The MAPKs extracellular signal-regulated kinase (ERK) and p38 can play an important role in translational control through the mRNA cap binding protein, eukaryotic translation initiation factor 4E (eIF4E). Downstream of stimuli, ERK or p38 can …
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Chemical Mixtures of Xenoestrogens and Their Metabolites Alter Estradiol-Induced Non-Genomic Signaling
… an automated screening system for changes in MAPKs activities due to XE exposures. RESULTS: XEs often activated MAPKs in a non-monotonic dose- and oscillating time-dependent (2.5-60 min) manner and attenuated 1nM E2 responses. While individual bisphenols did not activate JNK as NP did, the …
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Increased Geranylgeranylated K-Ras Contributes to Antineoplastic Effects of Farnesyltransferase Inhibitors.
… active GG’d K-Ras which activates ERK and p38 MAPKs to reduced cell viability and induce cell cycle arrest in malignant cells. This is the first report that identifies increased activity of GG’d K-Ras contributes to antineoplastic effects from FTI by increasing the activity of downstream …
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Pharmacological effect of MEK inhibitors on plasmodium falciparum
… cells. The Mitogen Activated Protein Kinases (MAPKs) are quasi-ubiquitous in eukaryotes, where they play crucial roles in the regulation of cell proliferation and differentiation in response to extra-or intracellular stimuli. The MAPKs typically function in 3-component modules comprising the …
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Biological and biochemical characterization of the extracellular signal-regulated kinase 8 homolog (TbERK8) in Trypanosoma brucei
… stimuli and are involved in essential processes. MAPKs can regulate differentiation, virulence, apoptosis, cell cycle and gene expression, which makes MAPKs interesting drug targets in T. brucei. The extracellular-signal regulated kinase 8 homolog in T. brucei (TbERK8) is essential for survival in …
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The Regulatory Role of Mixed Lineage Kinase 4 Beta in MAPK Signaling and Ovarian Cancer Cell Invasion
… negatively regulates the activities of the MAPKs, p38, ERK and JNK, even in response to stimuli such as sorbitol or TNFa. MLK4beta; also negatively regulates basal, but not TNFalpha-induced, NF-kappaB activity. Moreover, MLK4beta; undergoes autophosphorylation and has kinase activity towards …
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BV-2 미세아교세포에서 PGE2 에 의한 LPS 유도 IFN-β생성 조절
… enhanceosome 전사인자 복합체에 의해서 조절된다고 알려져 있으나, PGE2 는 MAPKs 와 그 하위 단계인AP-1의 활성화에 유의한 억제작용을 보이지 않았다. 또한 NF-κB 의 활성화 뿐만 아니라 IRF3의 활성화에서도 PGE2 의 억제 효과는 확인되지 않았다. 이 결과로 미루어보아 PGE2 에 의한 LPS유도 IFN-β 생성의 억제는 전사인자 활성화 단계에서 관여되지 않음을 알 수 있다."
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Characterization of cathepsin B cysteine protease from Naegleria fowleri excretory-secretory proteins exerting immunomodulatory effects
… response in microglial cells and activation of MAPKs signal pathway.
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Cartilage mechanobiology and transcriptional effects of combined mechanical compression and IGF-1 stimulation on bovine cartilage explants
… signaling, mitogen activated protein kinases (MAPKs), and release of intracellular calcium have been confirmed in several laboratories. Studies with IGF-1: Insulin-like growth factor-I (IGF-1) is a potent anabolic factor capable of endocrine and paracrine/autocrine signaling. Previous studies …
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DUSP5 Regulation of Inflammation and Insulin Signaling
… signaling of mitogen-activated protein kinases (MAPKs) within adipocytes (i.e. fat cells) and muscle cells that drive systemic inflammation and insulin resistance, leading to T2D. Until recently, most studies focused on the role of upstream kinases that link TNF? to MAPK activation (i.e. …
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UNDERSTANDING HOW MAP KINASES INFLUENCE ENDOTHELIAL NITRIC-OXIDE SYNTHASE ACTIVITY
… programming, and eNOS phosphorylation by MAPKs (P38, ERK and JNK) was examined using <em>in vitro</em> kinase assays and immunoblotting. JNK phosphorylation at Ser<sup>114</sup> contrasts with ERK, which phosphorylated Ser<sup>600</sup>, and p38, which phosphorylated both sites. Literature …
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Defining novel targets and functions of the protein kinase DYRK2
… to the mitogen-activated protein kinases (MAPKs) and cyclin-dependent protein kinases (CDKs). Hundreds of substrates and interacting partner proteins have been identified for MAPKs and CDKs, whereas relatively little is known about the substrates and functions of DYRKs. DYRKs are …
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The Use of Dynamic Fluid Flow Strategies for Bone Tissue Engineering Applications
… molecules, mitogen activated protein kinases (MAPKs) and prostaglandin E2, were modulated with the flow regimen, but that expression of bone matrix proteins, collagen 1α1, osteopontin, bone sialoprotein (BSP), and osteocalcin (OC), were similar under continuous and intermittent flow. Thus, this …
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