Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"MAPKK"”.
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Regulation von MAPK Signalwegen durch die Sein/Threonin Kinase MLK3
… Zipper), die am engsten mit der Familie der MAPKK Kinasen verwandt ist. In der voliegenden Arbeit zeigen wir, dass MLK3 Cdc42/Rac induzierte JNK/SAPK Aktivität vermittelt, welches zu einer anschließenden Phosphorylierung und verstärkter transkriptioneller Aktivität des zur AP-1 Familie …
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Components of the Ubiquitin Proteasome System are Required for the Nonapoptotic Death of the C. Elegans Linker Cell
… protein, as well as tir-1/TIRdomain and sek-1/MAPKK, which may function in the same pathway as pqn-41. The let- 7 microRNA and its indirect target, the Zn-finger transcription factor LIN-29, also promote linker cell death, and may act early in the process. Our work suggests that components of …
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Estudo do processamento das memórias de curta e longa duração
… o inibidor da PKA, Rp-cAMPs, e o inibidor da MAPKK, PD 098059. Os dados obtidos confirmam também para essas cascatas a indução em um treino prévio de baixa intensidade de algum fenômeno celular de longa duração que torna o aprendizado de um segundo treino independente de PKA, MAPK ou síntese …
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Regulatory Architecture of Non-Apoptotic Cell Death Program in C. Elegans
… the mitogen-activated protein kinase kinase (MAPKK) SEK-1, and the glutamine-rich protein PQN-41. SARM and MAPKKs have been implicated in non-apoptotic degeneration of axon distal segments following axotomy, and some developmental and pathological cell death events in vertebrates resemble the …
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Investigating the regulation of tumour associated lipogenesis using the model organism, Saccharomyces cerevisiae
… believed to be via dual phosphorylation by the MAPKK Pbs2. However, results from the Nile red assay of the pbs2Δ mutant, demonstrated that accumulation of neutral lipids is not affected in this strain when compared to the wildtype. Further, a hog1Δpbs2Δ double deletion showed no additive affect …
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Utilising Yeast as a Model Organism to Deconstruct the Regulation of Tumour Associated Lipogenesis
… with the central MAPK (Hog1) activated in both a MAPKK (Pbs2) independent and dependent manner. Analysis of Hog1 phosphorylation during various growth phases, suggests that there are previously uncharacterised sites on Hog1 which are potentially phosphorylated during phase one by the protein …
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Endothelin-1 Induced Phosphorylation of ERK1/2 in Bovine Corneal Endothelial Cells
<p>The purpose of this study was to determine whether Endothelin-1 (ET-1) induced cellular responses in bovine corneal endothelial cells (BCECs) involves MAPK pathway by phosphorylating ERK1/2 protein kinase and to find out the phosphorylation patterns of ERK1/2 in confluent and sub-confluent …
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Using prophylactics to improve resistance against Enterobacteriaceae in chickens
… EGF receptor (EGFR), the mTOR protein, and the MAPKK MEK2 were all differentially phosphorylated. Using various ligands and inhibitors to determine the role of these pathways, norepinephrine stimulated Salmonella killing in a dose-dependent mechanism. Furthermore, inhibition of beta-adrenergic …
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MAPK and pro-inflammatory mediators in the walls of brain blood vessels following cerebral ischemia
… a three-tiered kinase cascade comprising a MAPKKK, that can activate MAPKK, which in turn activates and phosphorylates MAPKs [170]. Activation of MAPK pathways regulates the activity of a number of transcription factors that are present in the cytoplasm or the cell nucleus, such as Elk-1, …