Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"MAPK14"”.
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Human trophoblast survival and invasion in the developing placenta: autocrine regulation by hbegf
… an increase in cell migration through the ERK, MAPK14, JNK, or PIK3 pathways downstream of signaling through its ERBB receptors. Also downstream of these four pathways, HBEGF induces a post-transcriptional increase in ITGA1 and decrease in ITGA6 expression (i.e., integrin-switching). This …
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Synthesis and evaluation of novel kinase inhibitors as anti-cancer agents
… other kinases, namely aurora A (AURKA), p38 (MAPK14) and Hgk(MAP4K4). These compounds represent exciting potential new anti-cancer compounds dueto the fact that they inhibit cancer-associated kinases whilst displaying low cytotoxicity.
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Glycogen Synthase Kinase 3 Is Required For Optimal Akt Activation
… revealed an increase in levels of phosphorylated MAPK14 (p38). Treatment with the selective p38 inhibitor SB 202190 rescued AKT activation in that cell line, corroborating the importance of unbiased proteomic analysis in exposing cross-talks between signaling networks and demonstrating a critical …
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Computational analysis of cell-cell communication in the tumor microenvironment
… transition in tumor cells via MAPK1 and MAPK14 signaling. Overall, the methods developed in this thesis provide a foundational computational framework for constructing "multi-scale" models of communication networks in multi-cellular tissues.
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Tyrosinkinaseinhibition bei humanen Non-Hodgkin-Lymphomen: Präklinische Evaluation von Sorafenib
Ein Großteil der Patienten mit aggressiven Lymphomen kann heute durch den Einsatz einer zytostatischen Therapie von der Erkrankung geheilt werden. Für Patienten mit peripheren T-Zell-Lymphomen oder Patienten mit rezidivierten Lymphomen stehen allerdings meist keine Therapieoptionen mit kurativem …