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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 100 for “"MAPK pathway"”.

  1. Characterization of the cell wall integrity MAPK pathway in Fusarium graminearum

    Gonzalez-Peña Fundora, Dianevys, University of Lethbridge. Faculty of Arts and Science2022

    lethbridge

  2. The Kras/Mapk Pathway and Ligand Independent Activation of Erα: Implications For The Treatment of Endometrial Cancer

    Ring, Kari2014

    … Member kinases of the PI3K/AKT and Ras/MAPK pathways activate estrogen receptor α (ERα) independent of estrogen, however, few studies have evaluated the role of the Ras/MAPK pathway in predicting response to hormonal therapy in EC. The aims of this project were to evaluate the role of …

    uthsc Repository record

  3. Systems modeling of quantitative kinetic data identifies receptor tyrosine kinase-specific resistance mechanisms to MAPK pathway inhibition in cancer

    Claas, AllisonMassachusetts Institute of Technology2017

    … RTK level changes, but also emphasizes the RTK, pathway target, and inhibitor variation of RTK reprogramming in drug resistance.

    mit Repository record

  4. The role of the systemic inflammatory response, the JAK STAT pathway and the MAPK pathway in the prognosis of resectable pancreatic cancer

    Denley, Simon M.University of Glasgow2008

    … that upregulation of two IL-6-dependent pathways, the JAK STAT and MAPK pathways is responsible for the poor prognosis associated with an inflammatory response in pancreatic cancer. Both of these pathways are known to be involved in cellular growth, differentiation and apoptosis and when …

    glasgow Repository record

  5. The Role of the Mitogen Activated Protein Kinase Pathway in Cisplatin and Noise-Induced Hearing Loss

    Lutze, Richard DennisCreighton University2024

    … causes of hearing loss. There are many cellular pathways involved in both types of hearing loss and the mitogen activated protein kinase (MAPK) pathway is one. The MAPK pathway consists of a phosphorylation cascade with RAF, MEK1/2, ERK1/2 as the main three kinases that effect a multitude of …

    creighton Repository record

  6. The Oncogenic Map Kinase Signaling Pathway Modulates Mhc-I Surface Expression In Melanoma

    Bradley, Sherille Denae2014

    <p>The mitogen-activated protein kinase (MAPK) pathway is a cascade of serine-threonine kinases involved in cell growth, proliferation, and apoptosis; it is one of the most well-known pathways associated with melanoma progression. The MAPK pathway is constitutively activated in melanomas due to …

    uthsc Repository record

  7. Polyunsaturated Fatty Acids and the Epidermal Growth Factor Receptor/ Mitogen- Activated Protein Kinase Signal Transduction Cascade in Mammary Cancer

    Phipps, Brandy EllenVirginia Tech2004

    … cancer, therefore investigating the molecular pathways of disease progression in one species may provide useful information for both. The EGFR/MAPK signal transduction pathway is upregulated in many human breast tumors, and both EGFR and MAPK have been implicated as independent prognostic …

    vt Repository record

  8. Procaspase-3 activation as a strategy to overcome resistance to targeted anticancer therapies

    Peh, JessieUniversity of Illinois at Urbana-Champaign2018

    … kinases in the mitogen-activated protein kinase (MAPK) pathway. Next, I will discuss the prevalence of oncogenic drivers in the MAPK pathway and the development of inhibitors as targeted anticancer therapeutics. Finally, I will explore the prospects of caspase-mediated degradation of MEK1/2 …

    uiuc Repository record

  9. Juvenile pilocytic astrocytomas: A search for prognostic markers

    Osman, NaeemDepartment of Pathology2022

    … light microscopic features. Activation of the MAPK pathway of cell proliferation is a consistent finding in these tumours. Studies of these tumours are largely aimed at components of this pathway in an effort to establish reliable prognostic and predictive markers. Aims and objectives: Our …

    cape-town Repository record

  10. Establishment of MITF and TAZ as major determinants of uveal melanoma

    Phelps, Grace B.Massachusetts Institute of Technology2022

    … present with activating mutations in the GNAQ/11 pathway, which signals through PLCβ4-MAPK and YAP, whereas CM is primarily driven by activation of the MAPK pathway. It has been well established that CM tumors are dependent on MITF, the master melanocyte transcription factor. Here, in stark …

    mit Repository record

  11. Social defeat and oxytocin regulation of social avoidance and stress-related signaling proteins

    Nerio Morales, Lina KarinaUniversity of Kansas2022

    … of the mitogen-activated protein kinase (MAPK) pathway. This cascade has been previously associated with the regulation of the anxiolytic effects of oxytocin, making it an intriguing molecular target in the study of SAD. Here, we used female prairie voles to study the regulation of social …

    ku Repository record

  12. Roles For B-Raf Kinase In The Specific Regulation of Α4Β1 Integrin In T Cells

    Brown, Wells S2014

    … The mitogen activated-protein kinase (MAPK) pathway is known to be downstream from integrins and regulate survival, differentiation, and motility. However, secondary roles for canonical MAPK pathway members are being discovered. We show chemical inhibition of RAF by Sorafenib or …

    uthsc Repository record

  13. Delivering Signal-Altering Bacterial Effector Proteins to Mammalian Cells Using Cell-Penetrating Peptide Technology

    Dickson, Robert2019

    … role of the mitogen activated protein kinase (MAPK) pathway in eukaryotes is to activate the bacterial pathogen defense response upon the detection of bacterial products in the environment. This defensive signaling results in the induction of inflammation, the transcription of antimicrobial …

    kennesaw Repository record

  14. Identification of Cell Signaling Pathway Regulated By Micrornas In Cancer Cells Using A Systems Biological Approach

    Kim, sangbae2015

    … reflect the association of miRNAs and signaling pathways, they were used to predict potential signaling pathways regulated by certain miRNAs. We implemented a web-based tool, miRPP, based on our approach. As validation of our approach, we also demonstrated that miR-500 regulates the MAPK pathway …

    uthsc Repository record

  15. The role of p90 ribosomal S6 kinases (RSKs) in Steroid signalling

    Cronin, Ryan JamesUniversity of Essex2019

    … on SR activity, the activity of the endogenous MAPK pathway and the significance of phosphorylation state. The PMA experiments indicated that in most cases PMA does not induce a significant change to RSK activity, thus the endogenous MAPK pathway is sufficiently active. The mutant experiments …

    essex Repository record

  16. Comprehensive Analysis of the Molecular Underpinnings of Pediatric Glioma

    Ryall, Scott Thomas2021

    … frequently harbor genetic alterations in the RAS/MAPK pathway, although a comprehensive molecular landscape of the disease has yet to be completed. To address this, we characterized a population-based cohort of >1,000 pLGG. We discovered that RAS/MAPK pathway dysregulation was universal in pLGG. …

    toronto-retro Repository record

  17. Design, Synthesis, and Biological Screening of Novel Cucurbitacin/ Estrone Analogs Towards Treatment of Melanoma

    Ahmed, Mahmoud Salama2017

    … Inhibition of Mitogen Activated Protein Kinase (MAPK) signal transduction pathway can subsequently lead to induce apoptosis assisting in the treatment of melanoma. Initially, the binding affinity of cucurbitacins towards mutant B-RAF V<sup>600E</sup> receptor was studied using in-silico modeling …

    sdstate Repository record

  18. Nitric oxide-induced DNA recombination & glycosaminoglycan mediated differentiation in stem cells

    Kiziltepe, Tanyel, 1976-Massachusetts Institute of Technology2005

    … levels, suggesting the involvement of the MAPK pathway. These results suggest that stem cell differentiation can be regulated by modulating the HSGAG moiety and this opens up new treatment modalities for cancer therapy and regenerative medicine.

    mit Repository record

  19. Proteins and instability elements involved in phosphoenolpyruvate carboxykinase mRNA turnover

    Hajarnis, Sachin Shrikant, author, Curthoys, Norman, advisor, Bamburg, James, committee member, Mykles, Donald, committee member, Laybourn, Paul, committee member, Wilusz, Jeffrey, committee memberColorado State University. Libraries2006

    … that is mediated by the activation of the p38 MAPK pathway. Our studies indicate that the activation of the p38 MAPK pathway also increases the stability of the PEPCK mRNA during chronic acidosis via its 3'-UTR. Luciferase assays and Northern blot analyses indicate that cAMP also prevents the …

    colostate Repository record

  20. The RASSF1A Tumor Suppressor Regulates a Cascade of Oncogenic Signals That Are Restrained by G1 Checkpoint Mechanisms

    Ram, Rosalyn Ruanga2012

    … RASSF1A depletion elevated oncogenic signaling pathways; however, RASSF1A depletion also induced cell cycle arrest. RASSF1A is a critical regulator in maintaining the balance between pro-growth and anti-growth signals. RASSF1A suppresses proliferative signaling pathways such as the MAPK pathway, …

    utswmed Repository record

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