Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"MAPK p38"”.
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Differences in the regulation of Thrombospondin-1 expression between epithelial cells and fibroblasts
… Myc by a Ras-induced pathway that activates the MAPK p38. This work also demonstrates that repression of Tsp-1 in human fibroblasts requires the combined inhibition of the tumor suppressors p53 and pRb. These results suggest that the molecular requirements for the induction of angiogenesis differ …
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Neuroglial Mechanisms Involved In The Anti-Inflammatory Effect Of Acetate Supplementation
… acetylation, mitogen-activated protein kinase (MAPK), nuclear factor-kappa B (NF-κB), and eicosanoid signaling. A single oral dose of acetate treatment (6 g/kg) in normal animals induced a time- and site-specific pattern of histone hyperacetylation, associated with reduction of histone …
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Caractérisation des facteurs de transcription impliqués dans l'expression génique de cytokines chez les neutrophiles humains
… dépend fortement de l'activation des voies p38 MAP kinases (aux niveaux transcriptionnel et traductionnel) et MEK/ERK (au niveau traductionnel seulement). Dans le deuxième chapitre, nous avons étudié l'expression et la localisation des différents facteurs de transcription de la famille …
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Label Transfer Reagents for the Investigation of Protein Kinase Complexes
… complexes. The mitogen-activated protein kinase (MAPK) p38 is involved in multiple pathways, and its regulation depends on its interactions with other signaling proteins. However, the weak and transient nature of these interactions makes the identification of p38 interacting proteins challenging. …
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UNDERSTANDING HOW MAP KINASES INFLUENCE ENDOTHELIAL NITRIC-OXIDE SYNTHASE ACTIVITY
<p>Mitogen activated protein kinases (MAPK) p38 and ERK have both been reported to bind endothelial nitric oxide synthase (eNOS) with submicromolar affinity via proposed interactions with a pentabasic non-canonical MAPK binding sequence in the autoinhibitory insertion of eNOS. The neuronal isoform, …
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Staphylococcus aureus virulence factors dictate host signaling pathways and immune responses
… highlighted a role for agr-regulated genes in MAPK p38 phosphorylation and α-hemolysin in ERK phosphorylation and IL-8 expression in PMN. Continuing our studies of VF, chemotaxis inhibitory protein of S. aureus (CHIPS) inhibits monocyte chemotaxis. We hypothesized that CHIPS inhibited C5a …
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Understanding The Role Of Transforming Growth Factor-β Activated Kinase-1 During Inflammation in Diabetic Retinopathy
… the activation of TAK1 and downstream MAP kinase p38 activated by the treatment of pro-inflammatory factors; LPS and TNF-α, through western blotting. Treatment with LPS showed negative regulation of p38 by TAK1 in vitro in cells treated in non-diabetic conditions. Under conditions that mimicked …
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Tyrosinkinaseinhibition bei humanen Non-Hodgkin-Lymphomen: Präklinische Evaluation von Sorafenib
… globalen Kinase-Arrays wurden die MAP-Kinase p38 und AKT als Zielstrukturen von Sorafenib bei Lymphomen identifiziert. Diese Erkenntnisse zur Wirkung von Sorafenib auf Lymphomzelllinien besaßen auch Gültigkeit für primäres Lymphommaterial, wie anhand von Patientenproben gezeigt werden konnte. …
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Bedeutung von Interleukin-6, Oncostatin M und Interleukin-31 für die biochemische und immunologische Barrierefunktion der Haut
… and activator of transcription) as well as the MAPK (mitogen-activated protein kinase) Erk1/2. In contrast to IL-6, OSM additionally activated protein kinase B/Akt and the stress-activated MAPK p38. While the activation of MAPK occurred transiently with a peak at 30 minutes, the tyrosine …
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Identification des changements cellulaires déclenchés en conditions pathologiques aiguë et chronique du système cardiovasculaire par des approches à haut débit
… des partenaires d’interaction des MAPKs p38, connue pour sa nécessité chez les cardiomyocytes tout en ayant un potentiel néfaste lors d’une grande activation jumelée à un manque de connaissance de ses substrats cardiaques. Ce projet a permis d’identifier pour la première fois Srsf3, …
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Anti-Inflammatory Effect of Sulfur Dioxide and Sulfite on Cigarette Smoke Exposed Human Airway Smooth Muscle Cells
… the inflammatory response by its effects on the MAPK and NF-κB pathways. Although sulfur dioxide has been shown to induce inflammation and airway smooth muscle constriction, these effects primarily occur at higher concentration. The exception to this is a group of individuals with severe asthma, …
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Anti-Inflammatory Effect of Sulfur Dioxide and Sulfite on Cigarette Smoke Exposed Human Airway Smooth Muscle Cells
… the inflammatory response by its effects on the MAPK and NF-κB pathways. Although sulfur dioxide has been shown to induce inflammation and airway smooth muscle constriction, these effects primarily occur at higher concentration. The exception to this is a group of individuals with severe asthma, …
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Increased Geranylgeranylated K-Ras Contributes to Antineoplastic Effects of Farnesyltransferase Inhibitors.
… increasing Ras signaling through the ERK and p38 MAPK pathways can cause growth arrest or cell death. Ras requires prenylation – the addition of a 15-carbon (farnesyl) or 20-carbon (geranylgeranyl) group – to keep the protein anchored into membranes for effective signaling. N- and K-Ras can be …