Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 21 for “"MAPK cascade"”.
-
Analysis of robustness and stochasticity in biochemical networks
… which consists of a phosphorelay connected to a MAPK cascade, we predict signaling robustness to changes in kinetic rate constants by employing a computational sensitivity analysis. Consistent with the model predictions, we find that the input-output relation of signaling activation is severely …
-
Das Adapterprotein Gab1 in der Regulation der IL-6 Signaltransduktion
… expressed and mediates the activation of the MAPK and PI3K signaling pathways after stimulation with growth factors and cytokines. It was described that Gab1 is involved in the IL-6 mediated ERK-activation. However, the mechanisms of the activation of the MAPK-cascade after activation of the …
-
Funktion der Protein-Tyrosin-Phosphatase SHP2 bei der Interleukin 6 vermittelten Akutphase - Genregulation und T-Zell-Migration
… of Transcription)-pathway and the Ras/Raf/MAPK-cascade. The protein tyrosine phosphatase SHP2 (SH2 - containing tyrosine phosphatase) is recruited to gp130, the signaltransducing subunit of the IL-6R-Komplex, und is an adaptor for the Ras/Raf/MAPK-cascade. Here it could be demonstrated, …
-
The Role of EGFR Signaling in Gonadotropin-Induced Steroidogenesis
… activates the Mitogen Activated Protein Kinase (MAPK) cascade to promote steroidogenic acute regulatory (StAR) phosphorylation and translocation to the mitochondria. Interesting, PKA-mediated transactivation of the EGF receptor occurs via both intracellular, ligand-independent signaling, as well …
-
Protein phosphorylation regulation in Arabidopsis
… and mitogen-activated protein kinases (MAPKs) is reviewed. To further understand the regulatory functions of protein phosphatases and kinases, I carried out detailed functional analyses of kinase associated protein phosphatase (KAPP) and a MAPK cascade involving MAPK3 and MAPK6. KAPP is …
-
A Patankar Predictor-Corrector Approach for Positivity-Preserving Time Integration
… including the stratospheric reaction system, the MAPK cascade, and the Robertson reaction, is used to evaluate the performance of the corrected integrators. Results show that the corrected schemes successfully preserve qualitative properties without compromising numerical stability. Efficiency …
-
Characterization of theWound-Induced Signaling Pathway In Tomato
… pathway involves the activation of a MAP Kinase cascade. This dissertation details the characterization of components of the systemin-responsive MAPK cascade, including MAPKs, the putative systemin receptor, and MAPK Kinases. One of the initial signaling events after systemin perception involves …
-
Dynamics of gene expression and signal transduction in single cells
… well-conserved mitogen-activated protein kinase (MAPK) cascade to osmotic shock, combining experimental measurements and theoretical models.
-
Structural Analysis of Domain Swapping in the Protein Kinase: Crystal Structure of Human Ste20 OSR1 Kinase Domain
… yeast MAP4K involved in the pheromoneresponsive MAPK cascade of the mating pathway. Recent studies reveal that its homologs in mammals, Drosophila melanogaster, Caenorhabditis elegans and other organisms constitute a large emerging group of protein kinases including 28 members in human. The …
-
Characterization of the Type III Effector VOPA from Vibrio Parahaemolyticus
… family, YopJ from Yersinia spp., inhibits the MAPK and the NFκB signaling cascades within the host cell, thereby inhibiting the host's innate immune response. Recently our lab elucidated the mechanism of YopJ's inhibition by demonstrating that YopJ acetylates MKKs and inhibits kinase activation …
-
Anthrax toxin effects on B lymphocyte function
… of the mitogen-activated protein kinase (MAPK) kinase family 1-7, with the exception of MEK5. This kinase family is responsible for activating the mitogen-activated protein kinase (MAPK) cascade. This cascade includes extracellular signal-regulated protein kinases (ERK), c-Jun NH2-terminal …
-
Endothelin-1 Induced Phosphorylation of ERK1/2 in Bovine Corneal Endothelial Cells
… corneal endothelial cells (BCECs) involves MAPK pathway by phosphorylating ERK1/2 protein kinase and to find out the phosphorylation patterns of ERK1/2 in confluent and sub-confluent cells. BCECs were isolated from bovine corneas and cultured in medium supplemented with 10% serum. Confluent …
-
Die Rolle des TEA/ATTS-Transkriptionsfaktors CaTEC1p bei der Hyphenbildung und Virulenz von Candida albicans
… albicans strains with mutations in the signaling cascades of hyphae formation which comprise Ras1p, a MAPK cascade and a cAMP-signaling pathway are compensated by the controlled overexpression of CaTEC1 . Moreover, the virulence of a C. albicans wild type strain is amplified by the CaTEC1 …
-
Biological response to 8-oxoguanine base released during DNA base excision repair
… transduces through the Raf-MEK(1/2)-ERK(1/2) MAPK cascade; 3) identified a chemical transformation of 8-oxo-Gua to a hydroperoxide-like form under physiological pH and oxygen atmosphere; and 4) determined 8-oxo-Gua-induced oxidative stress, which arises from the Rac1-Ras-NOX-PLA2-LO pathways, …
-
Components of the Ubiquitin Proteasome System are Required for the Nonapoptotic Death of the C. Elegans Linker Cell
… protein, as well as tir-1/TIRdomain and sek-1/MAPKK, which may function in the same pathway as pqn-41. The let- 7 microRNA and its indirect target, the Zn-finger transcription factor LIN-29, also promote linker cell death, and may act early in the process. Our work suggests that components of …
-
Mathematical Modeling and Computational Studies for Cell Signaling
<p>The mitogen-activated protein kinase (MAPK) cascades that are evolutionally conserved from yeast to mammals play a pivotal role in many aspects of cellular functions. The mating decision in yeast is a switch-like or bistability response that allows cells to filter out weak pheromone signals or …
-
Genetic and non-genetic determinants of drug response in type 2 diabetes
… activated protein kinase/MAPK cascade in glycaemic response toSU treatment suggesting the role of the post insulin secretion pathway inglycaemic response to SUs. In a study investigating joint effect of variants intransporter (<i>SLCO1B1</i> 521T>C) andmetabolizing …
-
Estrogenic modulation of place and response learning via specific receptor-mediated mechanisms
… and treatment design. Lastly, activation of MAPK signaling was examined in the hippocampi and striata of rats used in prior experiments. Phosphorlyation of ERK, a member of the MAPK cascade, appears to play a critical role in both learning and estrogen signaling in the brain. Results from …
-
Sex in Cryptococcus: Signaling, Mating-type Locus Evolution and Gene Silencing
… it is less clear what lies upstream of the MAPK cascade. To address this question, we studied the role of two Gα subunits (Gpa2, Gpa3) in mating and concluded that they share both redundant and divergent roles in mating. gpa2 gpa3 double mutants, but neither gpa2 nor gpa3 single mutants, are …
Page 1 of 2