Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"MAPK Signaling Pathway"”.
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Regulation of Adult Neurogenesis by the ERK5 MAPK Signaling Pathway and its Functional Implications in Learning and Memory as well as Olfaction
… adult brain to continuously produce new neurons, signaling mechanisms regulating this process have not been fully elucidated. Intrinsic differences between the two neurogenic regions including the microenvironment lend additional motivation to identify similarities and differences in regulatory …
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BASIGIN-2 MEDIATED ACTIVATION OF ERK1/2 SIGNALING IN HUMAN GLIOBLASTOMA MULTIFORME CELLS
… of the Mitogen-Activated Protein Kinase (MAPK) signaling pathway proteins, ERK1/2. This effect was mediated by rBsg-ECD binding to the Basigin-2 (Bsg-2) at the cell surface. In this research, U87-MG human GBM cells were treated with purified rBsg-ECD protein to measure changes in the …
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Statistical methods to infer biological interactions
… novel context dependent interactions in the MAPK signaling pathway and insights into the protein homeostasis machinery. In the second part, we focus on methods to understand the link between genotypes and phenotypes. First, we characterize the effects of related individuals on standard …
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Role signální dráhy HOG MAPK při osmotickém stresu u Saccharomyces cerevisiae
THE ROLE OF HOG MAPK SIGNALING PATHWAY DURING OSMOTIC STRESS IN SACCHAROMYCES CEREVISIAE Budding yeast (Saccharomyces cerevisiae) cells utilize a conserved mitogen-activated protein kinase (MAPK) signaling cascade (the high- osmolarity glycerol or HOG pathway) during conditions of increased …
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Generation and characterization of spred-2 knockout mice
… of membrane-associated proteins inhibiting the MAPK signaling pathway by interacting with Ras and Raf-1. Different studies have already demonstrated the inhibitory function of Spreds in cell culture systems, but the in vivo function of Spreds in the whole organism was still unclear. Therefore, …
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Translational mechanisms of stem cell fate regulation in epidermal oncogene tolerance
… or cancers despite germline mutations in the RAS/MAPK signaling pathway. Here, we find that oncogenic RAS-induced progenitor cell hyperproliferation is coordinated with differentiation to restrain aberrant growth and preserve epidermal development. We uncover a novel translation mechanism mediated …
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Mechanism of Spermatogonial Stem Cell Regulation by ETV2
… which could lead to disruption of GDNF/RET/GFRA1 signaling pathway, known to be essential for SSC self-renewal. By using a spermatogonial cell line we investigated the factors that regulate Etv5 in germ cells and found FGF-2 and EGF up-regulate Etv5 mRNA and that FGF-2 mediated up-regulation …
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Investigating the negative regulatory role of neurogranin in IgE-mediated mast cell activation
… is a protein that regulates Ca2+-mediated signaling pathways by binding and sequestering of CaM, subsequently acting as a critical suppressor of calcineurin phosphatase activity. Neurogranin was previously thought to exist exclusively in the brain; however, this is the first study to …
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Constitutively active-RSK2 induces chromosomal instability through diverse mechanisms
The Ras/mitogen-activated protein kinase (MAPK) signaling pathway regulates various cellular processes including cell survival, cell proliferation cell motility and cell cycle regulation. And mutation or activation of the signaling pathway has been related to cancer development. Cancer cell has a …
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Concomitant Targeting of The Mtor/Mapk Pathways: Novel Therapeutic Strategy In Subsets of Non-Small Cell Lung Cancer
… worse overall survival. There was enrichment of MAPK pathway genetic aberrations in key oncogenes (e.g. <em>KRAS, BRAF, NF1</em>) associated with <em>RICTOR</em> altered cases, underscoring that RICTOR could serve as an important co-oncogenic driver in specific molecular settings. Moreover, we …
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Sulfate -Reducing Bacteria and Their Contribution to Intestinal Epithelial Disorders
… mediated by mitogen-activated protein kinases (MAPK) ERK and p38, as revealed by kinase inhibition studies. Microarray analysis using an Affymetrix Rat Array(TM) confirmed that exposure to H2S (90 min) caused acute hypoxia, as indicated by increased expression of hypoxia-response genes and genes …
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Molecular factors influencing epithelial-mesenchymal transition in breast cancer
… carcinogenesis it has previously been shown that signaling from the oncogenic receptor tyrosine kinase c-erbB2 (HER2), frequently overexpressed in mammary cancers, induces EMT. In this system, c-erbB2-induced EMT was significantly delayed by high cell-density and cell-cell-dissociation occurred …
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Pharmacological Inhibition of LSD1/KDM1A in Diffuse Midline Glioma Models and Impact on Kinase Signaling
… prior studies that LSD1 can interact with kinase signaling pathways in other cancer models. Our lab has shown that LSD1 may regulate kinase signaling pathways and that LSD1 inhibition and LSD1 knockdown share biological implications on cellular processes in adult glioblastoma models. Receptor …
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Insulin-like growth factor binding protein-3 (IGFBP-3) plays an essential role in cellular senescence: molecular and clinical implications.
… senescence. One primary component of the IGF signaling involves IGFBP-3. It is well documented that IGFBP-3 levels are significantly increased in senescent human diploid fibroblasts however IGFBP-3 function is not known in this system. Interestingly, Werner syndrome fibroblasts, commonly used …
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Der Einfluß von Zytokinen und Zell-Zell-Kontakten auf die Expression von Matrix-Metalloproteinasen beim multiplen Myelom
… inhibition of the mitogen actived kinase (MAPK) signaling pathway by pharmacological inhibitors suggested an involvement of the p38-Kinase in the increased MMP-expression. In conclusion, a noticeable influence of multiple myeloma cells on MMP expression in non-malignant stromal cells could …
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Limb cell behaviors in Monodelphis domestica growth and development: the effects of Fgf pathway activators and inhibitors
… 1). I then elucidated the role of the Fgf/MAPK signaling pathway in driving these cellular processes (Chapter 2). Results suggest that molecular signals from within the limb drive differences in cell proliferation and focal adhesion that contribute to the differential growth of the fore- …
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Aberrant Ras/MAPK signaling in skeletal development
The Mitogen-activated protein kinase(MAPK) signaling pathway has been studied intensively in the context of neoplastic transformation. Other studies have focused on the roles of this pathway during development and have modeled syndromes, such as Noonan Syndrome (NS), that are caused by aberrant …
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Genetic investigation of South Africans with the Noonan Syndrome phenotype using targeted next generation sequencing
… ten genes encoding proteins integral to the Ras/MAPK signaling pathway. Pathogenic variants in these genes account for 70-80% of NS cases. The clinical diagnosis of NS can be challenging in some cases, even when performed by experienced clinicians. The introduction of Next Generation Sequencing …
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FGF signaling in specification of hESC-derived definitive endoderm
… the role of fibroblast growth factor (FGF) signaling, specifically FGF2 and FGF4, and Retinoic acid (RA) in specification of the hESC-derived DE development. Studies in lower vertebrates have demonstrated that FGF2 acts in a restricted manner primarily patterning the ventral foregut endoderm …
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Identification and characterization of gene and microRNA networks associated with cancer survival and drug abuse
… that result in the dysregulation of pathways. To detect the progression of drug exposure pathways, meta-analysis of five individual microarray experiments measuring gene expression in the brain of mice under acute and chronic drug exposure was performed. Functional analysis and …
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