Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 84 for “"MAPK SIGNALING"”.
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Aberrant Ras/MAPK signaling in skeletal development
The Mitogen-activated protein kinase(MAPK) signaling pathway has been studied intensively in the context of neoplastic transformation. Other studies have focused on the roles of this pathway during development and have modeled syndromes, such as Noonan Syndrome (NS), that are caused by aberrant …
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Regulation and Dysregulation via Docking Interactions in WNK and ERK1/2 MAPK Signaling
… for nearly every cellular process. Within signaling pathways, such interactions carry out numerous functions such as defining substrate specificity, inhibition of both other interactions and enzyme activity, localizing signaling partners, acting in a switch-like manner depending on …
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The Regulatory Role of Mixed Lineage Kinase 4 Beta in MAPK Signaling and Ovarian Cancer Cell Invasion
… (MAP3Ks). As components of a three-tiered signaling cascade, MAP3Ks promote activation of mitogen-activated protein kinase (MAPK), which in turn regulates different cellular processes including proliferation and invasion. Here, we show that the beta form of MLK4 (MLK4beta), unlike its close …
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Regulation of acid-stimulated H+ secretion by Pyk2 and MAPK signaling pathways in the outer medullary collecting duct
… pH and is involved in the regulation of MAPK signaling pathways and transporter activity. Therefore we examined whether the Pyk2 and MAPK up-regulate ATPase mediated proton secretion in response to decreased pH in outer medullary collecting duct cells. Immunoblot analysis of …
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Regulation of Adult Neurogenesis by the ERK5 MAPK Signaling Pathway and its Functional Implications in Learning and Memory as well as Olfaction
… adult brain to continuously produce new neurons, signaling mechanisms regulating this process have not been fully elucidated. Intrinsic differences between the two neurogenic regions including the microenvironment lend additional motivation to identify similarities and differences in regulatory …
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Epigenetic Modification as a Therapeutic Target in BRAFV600E-mutated Metastatic Colorectal Cancer
… protein (BET) inhibition in vivo with standard MAPK-targeted therapies showed deeper inhibition of the MAPK signaling and improved efficacy. Enhancer blockade disrupted the regulation of core transcription factors (TFs) of CRC, including the ETS family, downstream of MAPK signaling. BET plus …
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Role signální dráhy HOG MAPK při osmotickém stresu u Saccharomyces cerevisiae
THE ROLE OF HOG MAPK SIGNALING PATHWAY DURING OSMOTIC STRESS IN SACCHAROMYCES CEREVISIAE Budding yeast (Saccharomyces cerevisiae) cells utilize a conserved mitogen-activated protein kinase (MAPK) signaling cascade (the high- osmolarity glycerol or HOG pathway) during conditions of increased …
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BASIGIN-2 MEDIATED ACTIVATION OF ERK1/2 SIGNALING IN HUMAN GLIOBLASTOMA MULTIFORME CELLS
… of the Mitogen-Activated Protein Kinase (MAPK) signaling pathway proteins, ERK1/2. This effect was mediated by rBsg-ECD binding to the Basigin-2 (Bsg-2) at the cell surface. In this research, U87-MG human GBM cells were treated with purified rBsg-ECD protein to measure changes in the …
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Lateral Membrane Domains Organize and Regulate Components of Signal Transduction Pathways
… of the mitogen activated protein kinase (MAPK) signaling cascade also localized into domains in vesicles containing acidic lipids. The formation of lateral membrane domains induced by Ki-Ras 4B and the Raf-cysteine rich domain (Raf-CRD) was inhibited by the anti-tumor agent …
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Characterization of the Type III Effector VOPA from Vibrio Parahaemolyticus
… family, YopJ from Yersinia spp., inhibits the MAPK and the NFκB signaling cascades within the host cell, thereby inhibiting the host's innate immune response. Recently our lab elucidated the mechanism of YopJ's inhibition by demonstrating that YopJ acetylates MKKs and inhibits kinase activation …
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The Role of EGFR Signaling in Gonadotropin-Induced Steroidogenesis
… activation stimulates cAMP production and PKA signaling. Protein Kinase A (PKA) signaling then triggers EGF receptor activation, which activates the Mitogen Activated Protein Kinase (MAPK) cascade to promote steroidogenic acute regulatory (StAR) phosphorylation and translocation to the …
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Alternative rownstream roles for Ste2p and an α-arrestin in sacccharomyces cerevisiae mating
… Receptors (GPCR) those are involved in the signaling of mating responses that lead to cell fusion. Their signaling–associated interactions with G-protein/MAPK signal transduction machinery are well established, homologous to those in mammalian systems, and serve as a simplified model system …
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Genetic analysis of p38 mitogen-activated protein kinase signaling in innate immunity and stress physiology of Caenorhabditis elegans
… in evolutionarily diverse species. A pivotal signaling pathway in the evolutionarily conserved innate immune responses of multicellular organisms is the stress-activated p38 mitogen-activated protein kinase (MAPK) pathway. This thesis focuses on the physiological role of p38 MAPK signaling in …
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Post-translationally Modified Glucocorticoid Receptors and Protein Tyrosine Kinase 6 Modulate Triple Negative Breast Cancer Phenotypes
… of advanced cancer phenotypes in TNBC. Altered signaling pathways typify breast cancer and serve as direct inputs to steroid hormone receptor “sensors.” We previously reported that phospho-Ser134-GR (pS134-GR) species are elevated in TNBC and cooperate with hypoxia-inducible factors, providing a …
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The Study of Wnt Signaling Effector POP-1/TCF in C. Elegans Early Embryos
In C. elegans embryos, the combined Wnt/MAPK pathway polarizes the founder cell of mesendoderm, EMS blastomere, such that EMS produces two daughters with distinct developmental fates. The posterior daughter E, whose fate is specified by Wnt/MAPK, generates intestinal tissues (endoderm), whereas the …
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An Oxanthroquinone Derivative Disrupts Ras Plasma Membrane Localization and Function By Inhibition of Acylpeptide Hydrolase and Perturbation of Sphingomyelin Metabolism
… G01 significantly abrogated RAS-RAF-MAPK signaling in MDCK cells expressing constitutively activated, oncogenic mutant RASG12V. G01 also inhibited the proliferation of RAS-less mouse embryonic fibroblasts (MEFs) expressing oncogenic mutant KRASG12V or KRASG12D but not RAS-less MEFs …
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Modulation of mitogenic signaling and growth by sympathetic adrenergic regulation
… evidence suggests that ARs are capable of signaling cross-talk with other G-protein coupled receptors (GPCRs) as well as other receptor families, including receptor tyrosine kinases (RTKs). While the ARs have been implicated at numerous stages of heart failure, the adrenergic signaling …
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Scaffold-Mediated Organization of Signal Transduction Networks
… stimuli. Given the ubiquitous nature of this signaling pathway, it is not clear how specialization with respect to various Raf-dependent phenomena is acquired. In theory, functional specificity could be achieved by selectively coupling the core enzymatic components of a cascade to other …
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Limb cell behaviors in Monodelphis domestica growth and development: the effects of Fgf pathway activators and inhibitors
… 1). I then elucidated the role of the Fgf/MAPK signaling pathway in driving these cellular processes (Chapter 2). Results suggest that molecular signals from within the limb drive differences in cell proliferation and focal adhesion that contribute to the differential growth of the fore- …
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Statistical methods to infer biological interactions
… novel context dependent interactions in the MAPK signaling pathway and insights into the protein homeostasis machinery. In the second part, we focus on methods to understand the link between genotypes and phenotypes. First, we characterize the effects of related individuals on standard …
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