Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"MAPK (mitogen-activated protein-kinase)"”.
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Caractérisation du mécanisme d'action du récepteur sérotoninergique de type 5-HT2A dans les cellules de choriocarcinomes placentaires humains BeWo et JEG-3
… de muscles lisses vasculaires via la voie MAPK («mitogen-activated protein kinase») et les cellules musculaires squelettiques via la voie JAK/STAT («Janus-activated kinase/signal transducers and activators of transcription»). Des travaux réalisés dans le laboratoire de Dre Vaillancourt ont …
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The role of purinergic receptors in the modulation of JNK signalling endothelial and cancer cells
Purinergic receptors (P2YR) are a family of G-protein coupled receptors (GPCRs) which have been shown to regulate MAPK (mitogen activated protein kinase) signalling to elicit pro-inflammatory responses in diseases such as atherosclerosis.1,2 Within the MAPK family, JNK (c-Jun NH2-terminal kinase) …
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Microfluidic Approaches for Probing Protein Phosphorylation in Cells
Protein phosphorylation plays critical roles in diverse cellular functions, including cell cycle, growth, differentiation, and apoptosis. Deregulated phospho-signaling is often associated with many human diseases and cancers. Despite tremendous efforts to investigate the molecular mechanisms that …
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Bedeutung von Interleukin-6, Oncostatin M und Interleukin-31 für die biochemische und immunologische Barrierefunktion der Haut
… The family of multidrug resistance-associated proteins (MRP) are efflux transporters which protect skin cells from xenobiotica and promote inflammatory defence responses against pathogens through the export of prostaglandins and leukotrienes. In the first part of this thesis we investigated the …
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Effects of Cadmium on VCAM-1 Expression
… Vascular cell adhesion molecule-1 (VCAM-1)의 변화와 Mitogen Activated Protein Kinase (MAPK) 저해제들이 VCAM-1의 변화에 미치는 효과를 관찰하였다. 그 결과, 카드뮴 처리 2시간째 VCAM-1 mRNA의 발현이 증가하였고 카드뮴 처리 4시간째에 VCAM-1 단백질 발현이 증가하였다. 그리고 이러한 부착분자의 발현변화가 어떤 세포신호체계를 경유하는지를 알아보기 위해 신호전달물질인 MAPK의 억제제를 사용한 결과, p38 MAPK 억제제 (SB202190)와 …
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Expression und Funktion von Caveolin bei glialen Zellen, insbesondere Oligodendrozyten
… autophosphoryliert wird. Dies wurde mittels MAPK in-gel Kinase-Assays gezeigt. Die Behandlung von Schweine-OL mit Cholesterin, einer wichtigen Komponente von CMD, begünstigt das Fortsatzwachstum. In Kombination mit NGF wird dieser Effekt auf die Fortsatzbildung sogar noch verstärkt.