Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"MAPK/ERK"”.
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The Roles of EGFR and FGFR2 in Cell Shape Maintenance of Human Lung Tip Progenitor Epithelial Cells
… EGF and FGF10 cannot. FGF7 activates sustained MAPK/ERK and PI3K/AKT pathways when assayed using kinase translocation reporters, and inhibition experiments show that both downstream pathways are required for cell shape maintenance. The MAPK/ERK and PI3K/AKT pathways regulate proliferation, …
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Einfluss der Überexpression des zellulären Prionproteins auf ischämisch induzierte neuronale Schädigung in vivo
… der zelltodrelevanten PI3-Kinase/Akt und MAPK/Erk-Signalkaskaden untersucht werden. In den durchgeführten Experimenten zeigten die TG35-Mäuse signifikant geringere Infarktvolumina und hatten eine reduzierte postischämische Erk1/2-Phosphorylierung. Die PrP-Überexpression hatte jedoch keinen …
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Effect of Maternal Hypoxia on Fetal Development: Programming of HIE Phenotype in Neonatal Rat Brain
… of the GR will be assessed. Finally, the MAPK/ERK pathway as part of the downstream of the neuroprotective mechanism of the GR against neonate HIE brain injury will be evaluated. To address these issues two rats model were established: perinatal hypoxia exposure model in time-dated …
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Effect of Neurotoxic Insults in Knock Out Cell Lines for the Study of Alzheimer's Disease
… μεταβολές σε κύριες σηματοδοτικές οδούς (MAPK/ERK) στις κυτταρικές σειρές knockout. Ωστόσο, τα κύτταρα APP-/- εμφάνισαν μειωμένη ενεργοποίηση της οδού MAPK/ERK μετά από οξεία έκθεση σε H₂O₂, ενισχύοντας τον ρόλο της APP στην ενδοκυτταρική σηματοδότηση. Τα ευρήματα αυτά υπογραμμίζουν …
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CHARACTERIZING THE ROLE OF FREE FATTY ACID RECEPTORS (FFARs) IN BREAST CANCER CELLS
… FFAR3 over-expression reduces the activation of MAPK/ERK, while FFAR2 is identified to inactivate YAP by upregulating LATS2 protein levels. On a contrast, FFAR1 is directly involved in enhancing ERK activation and EMT-related process like increased migration and morphological changes in …
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Molecular Mechanisms of Opioid Use Disorder in Human Brain Models
… through perturbation of the PI3K/Akt and MAPK/Erk second messenger systems and dysregulation of immediate early genes. The mechanistic insights from these human models may aid the discovery of novel pharmaceutical targets to treat OUD or prevent long-term consequences of drug exposure.</p>
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Σύγχρονα δεδομένα για τη διάγνωση και θεραπεία της ιστιοκύττωσης Langerhans / Current concepts for the diagnosis and management of Langerhans cell histiocytosis
… LCH, με την αναγνώριση της συμμετοχής της οδού MAPK/ERK και την ανίχνευση ενεργοποιητικών μεταλλάξεων, κυρίως της BRAF V600E και του MAP2K1. Τα δεδομένα αυτά επιβεβαίωσαν τον νεοπλασματικό χαρακτήρα της νόσου και συνέβαλαν στην ανάπτυξη στοχευμένων θεραπευτικών επιλογών. Η διάγνωση της LCH …
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Reactive Oxygen Species are Second Messengers in the Lysophosphatidic Acid Induced Survival Signaling of Ovarian Cancer
… growth and survival, including the PI3K/ Akt, MAPK/ ERK, and NF-κB pathways. We found that these signaling cascades are increased in SKOV3 ovarian carcinoma cells when stimulated with LPA. Furthermore, each of these pathways is positively regulated by reactive oxygen species (ROS), which are …
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An investigation into the role of Bcl-3 in toll-like receptor signalling
… role for Bcl-3 as a negative regulator of the MAPK-ERK pathway.
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The role of VIP family members in diabetic retinopathy
… and mammalian mitogen activated protein kinase/Erk kinase (MAPK/ERK) survival signaling pathways. Overall, these data indicate that these peptides, both in vivo and in vitro, perform a beneficial effect to attenuate some pathologic events occuring in DR.
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Targeting the Urokinase Plasminogen Activator System Combined with Chemotherapy-a Potentially Novel Therapeutic Approach for Pancreatic Cancer
… effects were mediated by inhibiting Akt and ERK phosphorylation, suggesting the involvement of the PI3K/Akt and MAPK/ERK pathways. This comprehensive study underscores the therapeutic potential of targeting the uPA system in PDAC, either individually or in combination with existing …
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The interconnected KIT receptor and Microphthalmia-associated transcription factor axis in melanoma
… Using inhibitors against SRC, PI3K, AKT, MEK ERK and p38 during KIT activation, we identified that these signaling pathways are essential components in communicating signals between KIT and MITF. The activity of KIT is regulated by the tetrapeptide insert in the extracellular juxtamembrane …
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Substratspezifität und Signaltransduktion zellulärer und onkogener Abl-Tyrosinkinasen
… seit vielen Jahren für die CML als ursächlich anerkannten Fusionskinase p210Bcr-Abl sind weitere Fusionskinasen unter Beteiligung der Abl-Kinase in Formen der sowohl CML als auch der ALL und CMML beschrieben worden. Diese seltener auftretenden Abl-Fusionskinasen umfassen sowohl Bcr-Abl Proteine …
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Nuclear Behaviors of ERK1/2 Signaling
… signal-regulated protein kinase (MAPK/ERK) kinase (MEK)- ERK pathway is essential for proper development and homeostatic regulation in eukaryotic cells. Many pathway functions are carried out by ERK1 and ERK2 (ERK1/2), serine/threonine protein kinases that interact with a large …
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Preclinical Development of a Pharmacologic Agent for the Treatment of Recurrent Acute Pancreatitis
… acinar cells. Apigenin reduced activation of the MAPK/ERK and NF-κB pathways, leading to suppression of PTHrP P3 promoter activity and IL-6 transcription. The second aim was to determine how apigenin limits pancreatic stellate cell (PSC)-mediated fibrosis. Apigenin inhibited PSC proliferation, …
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High MUC2 Biosynthesis and Production Augment Pro-Inflammatory Responses in Colonic Goblet Cells
… signaling pathways in WT, only the MAPK/ERK pathway reduced transcription in MUC2KO cells. CXCL8 mRNA from WT was more stable than MUC2KO cells, and this stability was reduced when ER stress was alleviated. This study identified that metabolically stressed goblet cells regulate the …
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Sulfate -Reducing Bacteria and Their Contribution to Intestinal Epithelial Disorders
… mediated by mitogen-activated protein kinases (MAPK) ERK and p38, as revealed by kinase inhibition studies. Microarray analysis using an Affymetrix Rat Array(TM) confirmed that exposure to H2S (90 min) caused acute hypoxia, as indicated by increased expression of hypoxia-response genes and genes …
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Effects of nerve growth factor on TGF-Beta,Smad signal transduction in PC12 cells
… presented involvement of components of both, the MAPK/Erk and the TAK1/MKK6 cascade, signal mediators of these pathways rank as candidates to mediate direct activation of Smad3. Smad3 is subsequently translocated to the nucleus and activates transcription in a Smad4-dependent manner. Negative …
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Src Homology 2 Domain-Containing 5’-Inositol Phosphatase-2 (Ship2) Is An Effector of Lymphatic Dysfunction
… and identify SHIP2 as a potential regulator of MAPK/ERK signaling, another pathway also recently identified as important in lymphatic malformations. Pharmacological inhibition of SHIP2 impedes lymphatic contractility and impairs the normal wound healing processes of lymphangiogenesis and …
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Novel Therapeutic Targets Identified By High-Throughput Technologies For Triple-Negative Breast Cancer
… protein expression of oncogenes involved in the MAPK/ERK and DNA repair pathways, and reduced the serum-starvation induction of biochemicals involved in oxidative stress response and glycolytic metabolism. shLRP8 MDA-MB-231 xenografts had reduced tumor volume, in comparison to parental and shCON …
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