Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 575 for “"MAPK"”.
-
p38 MAPK Signalling in Endothelial Apoptosis
… to express a dominant negative mutant Flag-p38 MAPK harboring T180A and Y182 F amino acid substitutions. Similarly to the TNF- induced cell death, we found a p38-mediated downregulation of Bcl-xL in cells undergoing doxorubicin-induced apoptosis. In contrast, MEK/ERK signalling appeared to be …
-
Aberrant Ras/MAPK signaling in skeletal development
The Mitogen-activated protein kinase(MAPK) signaling pathway has been studied intensively in the context of neoplastic transformation. Other studies have focused on the roles of this pathway during development and have modeled syndromes, such as Noonan Syndrome (NS), that are caused by aberrant …
-
Role of phosphatases in controlling arabidopsis mapk signalling cascades
… conditions. Mitogen-activated protein kinases (MAPKs) constitute a highly conserved family of enzymes in eukaryotes, and in plants MAPK-based signal transduction modules regulate a large number of physiological processes, including responses to environmental stresses and phytohormones. Regulated …
-
Regulation von MAPK Signalwegen durch die Sein/Threonin Kinase MLK3
MAPK Kaskaden spielen eine Schlüsselrolle bei der Übertragung und der Umwandlung von extrazellulären Reizen in intrazelluläre Signale und regulieren dadurch unterschiedliche Prozesse wie Differenzierung, Zellproliferation oder Stress Antworten. 'Mixed Lineage Kinasen' (MLKs) bilden eine Familie von …
-
Importance of MAPK and PKC in cerebrovascular endothelin receptor changes
Endothelin is a vasoactive peptide that exerts its effect through two receptors; the endothelin type A (ETA) and type B (ETB) receptor. The contractile ETA receptor is localized on smooth muscle cells in the vascular wall, while the ETB receptors are mainly situated on endothelial cells, mediating …
-
Macrophage-mediated resistance mechanisms against MAPK inhibitory by cancer therapeutics
Kinase inhibitors targeting the MAPK pathway are often limited by lack of durable clinical responses or, in many cancer types, lack of even initial responses. While great headway has been made on characterizing mechanisms of resistance, understanding the full influence of complex intercellular …
-
Role signální dráhy HOG MAPK při osmotickém stresu u Saccharomyces cerevisiae
THE ROLE OF HOG MAPK SIGNALING PATHWAY DURING OSMOTIC STRESS IN SACCHAROMYCES CEREVISIAE Budding yeast (Saccharomyces cerevisiae) cells utilize a conserved mitogen-activated protein kinase (MAPK) signaling cascade (the high- osmolarity glycerol or HOG pathway) during conditions of increased …
-
PPARγ agonism attenuates cocaine seeking behavior via association with ERK MAPK
The nucleus accumbens integrates information from a number of cortical and limbic structures such as the prefrontal cortex and hippocampus and alterations of this neurocircuitry during drug taking and abstinence is thought to underlie relapse behaviors. ERK, a protein vital for learning and memory, …
-
Regulation of Mnk1 by p38α MAPK in Stress Mediated Translation Initiation
… for subsets of mRNAs. Both the Erk1/2 and p38 MAPK pathways activate Mnk1 meaning that Mnk1 responds to growth signals through Erk1/2 and stress signals through p38 MAPK. However, it is not clear how Mnk1 mediates translational changes specific to each pathway. We investigated the activation of …
-
Chrysophanol-8-O-glucoside Attenuates Platelet Activation Through Inhibiting MAPK and PKCε
… we examined the effects of CP-8-O-glc on MAPKs, Akt, PKCε activation. ERK2, JNK1, Akt, and PKCε were significantly activated during collagen-induced aggregation, and the observation was inhibited by ERK inhibitor and CP-8-O-glc, which subsequently contributes to antiplatelet mechanism of …
-
Regulation and Dysregulation via Docking Interactions in WNK and ERK1/2 MAPK Signaling
… cellular signaling pathways, the WNK, and ERK1/2 MAPK pathways. The WNK pathway is an essential regulator of cellular ionic composition and volume. Initially discovered due to the genetic link between mutations in some of the WNK kinases and an inherited form of hypertension, the pathway is now …
-
TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling
… in melanoma cells to negatively regulate MAPK pathway and mTORC1 signaling. TRPML1-deficient melanoma cells exhibited decreased survival, proliferation, tumor growth, and macropinocytosis as well as serine depletion and proteotoxic stress. All of these phenotypes were partially or …
-
Die Rolle mitogener und stressinduzierter MAPK-Signalwege in der Regulation von keratinozytären Wachstums- und Differenzierungsvorgängen
… die Bedeutung Mitogen-aktivierter Proteinkinase (MAPK-) Signalwege in keratinozytären Wachstums- und Differenzierungsvorgängen untersucht. Es konnte gezeigt werden, daß Induktion von Keratinozytendifferenzierung durch Erhöhung der extrazellulären Calciumkonzentration mit einer raschen und …
-
ASCL2 Positive Tumor Cells Modulate the Response of Metastatic Colorectal Cancer to MAPK-Targeting Therapy
… in tumorigenesis, CRC is commonly treated with MAPK pathway inhibitors (MAPKi). However, clinical trials repeatedly demonstrates that durability of benefit is short-lived in many patients. While genomic mechanisms of acquired resistance have been described, they explain a minority of patients, …
-
MAPK and pro-inflammatory mediators in the walls of brain blood vessels following cerebral ischemia
… (MMPs) and mitogen activated protein kinase (MAPK) pathway because microarray work [8] and published data [9] primarily pointed at these. These parameters and the relationships between them were studied in the cerebrovascular walls after ischemic and hemorrhagic strokes. This study lends …
-
Regulation of the beta7 integrin gene in T cells: role of the MAPK signalling pathways
… proximal promoter is shown to be mediated by MAPK family members. TGF-β1 stimulation of TK-1 T cells increased the steady-state mRNA levels of the β7 gene relative to α4 transcripts, and led to enhanced phosphorylation of c-Jun. TGF-β1 stimulation induced rapid increases in the binding of …
-
Small Molecule Inhibitors of MAPK and PI3K Pathways Enhance MDA-7 Lethality in Renal Cell Carcinoma
… of cell death by upregulating JNK and p38 MAPK pathways, downregulating the ERK1/2 MAPK pathway, and downregulating the PI3K pathway. Western blots confirmed upregulation and downregulation of these pathways by probing for key proteins. Renal cancer cells responded best to infection with …
-
Hyperactive Rac1 Drives MAPK-Independent Proliferation in Melanoma by Assembly of a Mechanosensitive Dendritic Actin Network
… of the mitogen-activated protein kinase (MAPK) pathway, a frequent target for melanoma treatment. Rac1P29S bypasses the MAPK axis through a mechanism that necessitates cell-matrix attachment, however, does not depend on integrin-mediated focal adhesion assembly and focal adhesion kinase …
Page 1 of 29