Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"MAP2"”.
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Characterization of Oxidized Tau Protein Aggregation and Inhibition of Tau Aggregation via MAP2
… focus of our lab and other research labs. MAP2 is another intrinsically disordered protein that aids microtubule stabilization and also possesses high sequence homology with Tau. This similarity provided the motivation to explore whether MAP2 has an affinity for Tau aggregates and possibly …
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The effect of modified atmosphere packaging (MAP) on the shelf- life of refrigerated, cubed turkey thigh meat
… oxygen, and 20% nitrogen were used for MAP1 and MAP2 respectively. All sample packages, MAPl, MAP 2 , and Air Control, were stored at O.5°C. Headspace gas analysis, color measurement, sensory evaluation, aerobic plate count, and oxidative deterioration of fat were examined over 21 day of storage. …
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Tau Aggregation, Conformational Selection, and Inhibition
… <p>Microtubule associated protein 2 (MAP2) is a neuronal homologue to Tau and performs similar functions in the cell. MAP2 has not been shown to be a major antigenic component of the neurofibrillary tangles associated with disease. However, this does not exclude their presence in small …
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ABHD16A-proteiinia inhiboivien yhdisteiden toksisuuden tutkiminen hiiren kortikaalihermosoluilla
… Aluksi valittujen immunofluoresoivien MAP2-vasta-aineiden avulla solumäärää ei onnistuttu ohjelman avulla laskemaan, joten vaihdoimme vasta-aineita ja saaduista MAP2-värjätyistä kuvista otimme intensiteetin voimakkuuden. Tilastollisen merkitsevyyden arvioimiseksi datalle suoritettiin …
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Immunological investigations into synaptic plasticity
… a-tubulin and microtubule-associated protein 2 (MAP2) in specific forebrain loci following passive avoidance training in the chick. Of the regions examined, elevations in the titre of anti-a-tubulin were found in the left Intermediate Hyperstriatum Ventrale (IMHV) l hr, 6hrs and 24hrs following …
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Studies on the production of IL-1β, TNF-α, iNOS, IL-10, and ROS in the APP/PS1 mouse model of Alzheimer's disease
… decrease in NeuN-positive neurons and MAP2-immunoreactice dendrites. These results suggest that activated microglia surrounding plaques induce excessive production of pro-inflammatory mediators and ROS, leading to neuronal damage.
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Histological and Functional Characterization of Cervical Spinal Cord Injury After Graded Contusion
… (IR) and gray matter loss by MAP2-IR. There was a significant correlation between lesion size and gray matter loss and injury severity. Correlations between histology and behavior outcomes showed a significant correlation between the percentage of missteps in cHL, injury …
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Transcriptomic and Proteomic Studies of Intercellular Communication Between Melanocytes and Keratinocytes in Human Skin
… identified microtubule associated protein 2 (MAP2) as being upregulated in response to ET-1, which suggests a mechanism for how ET-1 induces changes in melanocyte morphology. I also found that the nerve growth factor receptor (NGFR) is upregulated in melanocytes in response to ET-1. This …
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Ncd Motor Tail Domain Interactions With Microtubules
… proteins, especially to tau and MAP2, that regulate MT assembly. Like tau MT binding motifs, MT binding sites of the tail domain are rich in basic amino acids that are flanked by proline residues. Cross-linking and MT co-sedimentation assays with subtilisin-digested MTs …
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MULTI-OMICS APPROACHES TO CHARACTERIZE PATIENT-DERIVED SPINAL CORD ORGANOIDS AND ASSESS NOVEL GENES ASSOCIATED WITH C9ORF72-AMYOTROPHIC LATERAL SCLEROSIS
… in cryosections of DIV80-SCOs, particularly DCX, MAP2, PAX6, OLIG2, GFAP, and HOXB4. Time course quantification of precursors (SOX2 and ISL1), as well as the progressive increase of post-mitotic MNs (TUJ1 and SMI32) supported proper organoids maturation. This outcome highlights SCOs potential as a …
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Investigation of the physiological function of TTBK2 (tau tubulin kinase 2), a protein kinase mutated in spinocerebellar ataxia type 11 (SCA11)
… microtubule-associated proteins (tau, tubulin, MAP2) in vitro (Takahashi et al., 1995, Tomizawa et al., 2001). Since this discovery by Japanese scientists in 1995, considerable work has been invested in examining TTBK2’s relationship with aberrant tau phosphorylation and neurodegeneration in …
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Investigating three-dimensional (3D) gelatin methacryloyl (GelMA) hydrogel as a potential scaffold for cell transplantation in Huntington's disease
… cells encapsulated in GelMA gave rise to MAP2+/STEM121+ and GABA+/STEM121+ cells, with a significantly higher number of PGP9.5+/STEM121+ cells compared to those transplanted with cell media. We also demonstrated the potential of TkB small molecules, LM22A-4 and 7,8-dihydroxyflavone, in …
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Protective effect of JAK3 inhibition on growth factor deprivation induced neural progenitor cell death
… the number of nestin, SOX2 (markers of NPCs) and MAP2(a marker of neuron) positive cells. But capability of proliferation of NSCs was not affected by JAK3 inhibitor. GFs withdrawal is known to induce apoptosis, which could detect by TUNEL(terminal deoxynucleotidyl transferase (TdT)-mediated dUTP …
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The effect of the cyanobacterial toxin saxitoxin on neurodevelopment
… the expression of neuronal markers nestin and MAP2 were increased following exposure to STX (3μg/L) while ßIII-Tubulin was delayed by 3 days in both STX treatment groups. This research is presented in chapter 4; “Low dose exposure to saxitoxin affects neuronal differentiation of D3 embryonic …
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Investigating the cytoskeleton and microtubule-based transport with in situ cryo-electron tomography
… revealed uniform polarity microtubule bundles in MAP2-expressing projections, suggesting that differentiated SH-SY5Y projections showed a mixed neurite phenotype. The signal:noise ratio (SNR) of these tomograms was too low to visualise most macromolecules in the cytoplasm. This made this approach …
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DISSECTING THE MOLECULAR MECHANISMS RELATED TO THE ONSET OF NEUROLOGICAL COMPLICATIONS IN THREE CELLULAR MODELS OF SARS-COV 2 INFECTION: IPSC-DERIVED MOTO R NEURONS, IPSC-DERIVED DOPAMINERGIC NEURONS, IPSC DERIVED-HUMAN CORTICAL ORGANOIDS.
… SARS-CoV-2 infection was associated with altered MAP2 and TAU expression and increased neuronal stress markers. These results suggest that SARS-CoV-2 affects dopamine metabolism and production, partially explaining the neurological symptoms. In parallel, for the very first time, we found that …