Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"MAP kinases"”.
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Determining the substrates for MAP kinases in Leishmania mexicana
… targets is essential. Mitogen-activated protein (MAP) kinases present a potential target; fifteen different MAP kinases have been found in L. mexicana, some of which have proven to be essential at various stages in the Leishmania life cycle. This project focuses on identifying substrates for three …
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UNDERSTANDING HOW MAP KINASES INFLUENCE ENDOTHELIAL NITRIC-OXIDE SYNTHASE ACTIVITY
<p>Mitogen activated protein kinases (MAPK) p38 and ERK have both been reported to bind endothelial nitric oxide synthase (eNOS) with submicromolar affinity via proposed interactions with a pentabasic non-canonical MAPK binding sequence in the autoinhibitory insertion of eNOS. The neuronal isoform, …
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Dietary fatty acids modulate inflammatory cytokine production through activation of MAP kinases
… acid @HA) and eicosapentaenolc acld (EPA), on MAP hnase signaling pathways and cytolune production in macrophages following achvation of these cells through these TLRs Macrophages are key cells involved in activation of innate immune responses. Ths study used the J774 munne macrophage cell line …
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The Role of Map Kinases On The Functional Heterogeneity of Human Cd8+ T Cell Maturation Subsets
While prior studies have focused on naïve (CD45RA+CD27+) and early stage memory (CD45RA-CD27+) CD8+ T cells, late memory CD8+ T cells (CD45RA+CD27) have received less interest because this subset of T cells is generally recognized as effectors, which produce IFNγ (but no IL-2) and perforin. …
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Rutas de señalización intracelular que regulan la apoptosis inducida por lovastatina en neuroblastos fetales de rata
… to the survival pathways Duch as RAS/RAF/MAP-kinases, PI3-K/PKB, as well as death pathways, stress-activated MAP-kinases (JUN-kinases and p38).
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Temporal evolution of intracellular signaling and gene expression following patterns of membrane depolarization in the pheochromocytoma cell line, PC 12
… activation of the mitogen-activated protein (MAP) kinases Erkl and Erk2, while the cAMP-response element binding protein (CREB) remained active at intermediate levels for over 60 minutes. Pulsatile depolarization also stimulated Erkl/2 and CREB activation, and the rate of deactivation of the …
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Signal transduction during defense response and source-sink transition in tomato
… is preceded by the transient activation of MAP kinases. In depth analysis of MAP kinase activation by partial purification led to the discovery that, depending on the stimulus, different subsets of MAP kinases are activated. This differential MAPK activation is likely to possess a signal …
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Characterization of an in Vivo Model of Temporomandibular Joint Inflammation
… investigate gap junction activity and identify MAP kinases activated in neurons and glia in response to NO/protons. Initially, cell bodies of neurons providing sensory innervation of the TMJ (V3 region), as well as the V1 and V2 regions, were identified by retrograde labeling with the …
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Stochastic regulation of signaling in lymphocytes
… In lymphocytes, mitogen-activated protein (MAP) kinases can be triggered by various stimuli (growth factors, cytokines, etc.) with significant cellular responses (proliferation, inflammation, etc.). We first investigate the roles of upstream proteins, Son of Sevenless (SOS) and Ras …
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Tail-anchored Triphosphate Tunnel Metalloenzymes in Arabidopsis thaliana: An Investigation into the Molecular Mechanisms underlying their Biological Functions
… extensive in vitro kinase assays identified two MAP kinases that phosphorylate TTM1 at S437, connecting these kinases to senescence via TTM1. I also identified a set of MAP kinases that phosphorylate TTM1 at two additional sites, S10 and S490. My data suggest that phosphorylation of these …
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Žūties ir išgyvenimo signalinių mechanizmų tyrimai suaugusio organizmo raumens kamieninių ląstelių diferenciacijos metu /
… prove that protein kinase Akt and ERK, p38, MAPK promote survival of differentiated cells during apoptotic treatments. The role of JNK kinase in apoptosis may depend on cell differentiation stage and type of apoptotic stimuli. We have proved that JNK has a potential to regulate pro- and …
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Angiotensin-(1-7) Reduces Prostate Cancer Growth and Metastasis by Altering the Tumor Microenvironment
… and a 55% decrease in the phosphorylation of the MAP kinases ERK1 and ERK2, compared to tumor tissue from Ang-(1-7)-medicated animals, suggesting that the heptapeptide reduces cell proliferation. A significant reduction in both LNCaP and PC3 cell growth was observed following incubation with 100 …
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Characterization of insulin-stimulated protein kinase cascade in normal and diabetic rats and the effects of vanadium
Multiple protein kinases acting in a sequential manner have been identified to constitute a kinase cascade that mediates growth factor or mitogen-activated signal transduction. The cascade is triggered at the cell membrane by the activation of receptor tyrosine kinases, which pass on the signal in …
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MAP kinase phosphatase-2 in vascular smooth cell muscle function
… occurs involves ligand-induced activation of MAP kinase signalling (Schad et al., 2011). MAP kinases have been noteworthy but troublesome targets in cardiovascular therapeutics; thus exploration of targeting endogenous regulatory dual specificity proteins namely MAP kinase phosphatases has …
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SCRIBBLE: A POTENTIAL DUAL KINASE INHIBITOR
Extracellular signal-regulated kinases (ERKs) modulate cellular activities in response to extracellular stimuli and play important biological roles. Thus, perturbed kinase pathways induce pathological conditions, such as tumor development. Rit, a novel member of the Ras family GTPases, activase …
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Mechanisms of Epidermal Growth Factor Receptor Regulation of Epidermal Proliferation and Skin Tumorigenesis in Response to Ultraviolet Irradiation.
… activation of extracellular-signal regulated kinases (ERK1/2), p38 kinase and c-Jun NH2-terminal kinase (JNK) increased keratinocyte proliferation.|Ultraviolet irradiation (UV), a common environmental carcinogen, causes both acute and long-lasting damage to the skin. We investigated the role …
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Mechanism and Regulation of ERK2 Subcellular Localization
… that regulated compartmentalization of the kinases and substrates may contribute to the fidelity of phenotypic changes in response to specific cell stimuli. Therefore, elucidating the mechanism of translocation as well as how this process is controlled is important for understanding how MAP …
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The redox regulation of alpha 5 beta 1 integrin stimulated MMP production in articular chondrocytes
Elevated levels of reactive oxygen species (ROS) have been observed in the cartilage of osteoarthritis (OA) patients and may contribute to the degradation of the articular cartilage extracellular matrix (ECM). ROS have been shown to serve as secondary messengers in integrin and cytokine signaling …
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Identifying Diagnostic Biomarkers: Gene Expression Profiling Leptin in Dental Pulp Tissue
… into R-package for analysis and sequence mapping to the appropriate gene. The genes and pathways were identified in KEGG pathways overlaying expression values. Over-expressed (p<0.05) genes include ACSL1, LEP, LEPR and PRKAA2 and under-expressed (p<0.05) genes include MAPK8, NFKBIE, RELA. …
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The role of galectin-3 and galectin-9 in the chronic inflammation of rheumatoid arthritis
… of those mediators. IL-6 release depended on MAP kinases p38, ERK and JNK as well as NFkB transcription factor, whereas CCL5 production required PI3/Akt and NFkB
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