Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 49 for “"MALS"”.
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Integrating Knowledge and Action: A Study of Leadership in the Development of Master's Degree Programs in Liberal Studies
Master's degree programs in liberal studies (MALS programs) have proliferated in the United States over the past twenty years. Studying the leadership relationships that faculty and administration form during the MALS program development process provides insight into how non-traditional graduate …
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Characterization of CAXCK31, a Bacterial Calcium/Proton Antiporter
… include chemical cross-linking, FRET, and SEC-MALS. In addition, various transport properties of CAXCK31, including substrate selectivity, pH dependence, and transport rates, have been characterized for the first time.</p>
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Einfluß von Medikamenten und Narkotika auf motorisch evozierte Potentiale nach transcranieller Cortexstimulation
… von 41 Probanden untersucht. Erst-mals wird die Wirkung von Benzodiazepin und dem Opioid Tramadol auf MEP quantifiziert. Unter Benzodiazepin kommt es dabei zu einer signifikanten Redukti-on von Amplitude und Fläche, die cortikomuskuläre Überleitungszeit bleibt unverändert. Tramadol …
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The Effect of PEG-Insulin and Insulin Hexamer Assembly on Stability in Solution and Dry Powders. Hexamer Assembly of PEGylated-Insulin and Insulin Studied by Multi-Angle Light Scattering to Rationally Choose the pH and Zinc Content for Analytical Methods and Formulations of Dry Powders.
… insulin in solution has been developed using the MALS (Multi-Angle Light Scattering). Insulin concentration, pH, and metal ion concentrations, were in pharmaceutically relevant ranges. The MALS method was developed to evaluate how the parameters above affect the self-assembly properties of …
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The design of multifunctional hydrogel nanoparticles for drug delivery
… erosion). Using multiangle light scattering (MALS), changes in particle molar mass and radius were measured, providing a quantitative and direct approach for monitoring nanogel erosion and macromolecule encapsulation. The new particle chemistries demonstrated, together with enabling light …
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THE SYNTHESIS AND CHARACTERIZATION OF DUAL-MODIFIED CARBOXYMETHYLCELLULOSE FOR BIOADHESIVE APPLICATIONS
… with multi-angle light scattering (SEC-MALS). The adhesive strength of the material was determined by lap shear testing with porcine skin. High molecular weight and medium molecular weight methacrylated dialdehyde carboxymethylcellulose (MeDCMCHV & MeDCMCMV) were engineered and MeDCMCHV …
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Branched Glycopolymers
… with a multi-angle light scattering detector (MALS) and 1H NMR. Finally, glycomethacrylate hybrid stars were synthesized using a silsesquioxane nanoparticles-based macroinitiator of ca. 58 initiator functions and MAIGlc as monomer via ATRP using the “core first” approach. Well-defined …
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A screen for novel interactions within the vertebrate centriole
… I validate this interaction in-vitro using SEC-MALS and map the binding region further using NMR. In the second approach towards identifying novel PPIs, I attempt to purify literature-predicted putative multi-protein sub-complexes of the centriole. In summary, the main objective of this thesis …
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Impacts des déversements d'hydrocarbures sur les écosystèmes marins
… effets à long terme qui sont jusqu'à maintenant mals connus, surtout dans le cas des organismes s'alimentant à des niveaux trophiques supérieurs, organismes susceptibles d'ingérer des produits toxiques concentrés à travers la chaine alimentaire.
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INVESTIGATION OF HETEROTRIMER-FORMING COLLAGEN-MIMETIC PEPTIDES THAT INCORPORATE AZA-GLYCINE RESIDUES
… We use circular dichroism, ESI-MS and SEC-MALS studies to develop CMP strands that possess a markedly reduced homotrimer stability, and to gain insight into the molecular species formed in these mixtures. We also present the application of fluorophore-tagged CMPs incorporating the …
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Regulation of inflammatory TLR signalling by the BCAP adaptor
… of the DBB domain in combination with SEC-MALS revealed that the DBB domain functions as a dimerisation region. First shown in NF-κB reporter assays, DBB domain dimerisation also prevents MAL TIR domain interactions in vitro. These results support a new model of steric inhibition of TIR …
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Stability Study of Engineered Ferritin Nano-vaccines by Combined Molecular simulation and Experiments
… of these proteins was verified using SEC-MALS, and the purity and recovery rate were measured using the Bradford assay and SDS-PAGE. A prepacked Butyl FF column was utilised to compare the hydrophobicity of the proteins, and fluorescence was employed to evaluate the changes in tertiary …
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Les moeurs de province dans les romans de Stendhal
… Notre étude non seulement des textes mals aussi des historiens qui ne partagent pas souvent les préjugé de Stendhal nous a conduits à trois conclusions. La peinture de moeurs provinciales faite par Stendhal, quoique limitée, est plus juste et plus en accord avec la vérité historique …
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Insights into the structure and aggregation of lens crystallins and other aggregation-prone proteins
… conformational aspects in comparison to SEC-MALS. The method distinguished between BSA oligomers and two different monomer populations, multiple YADH monomer and tetramer conformations, and apo- and holo-BLA. The 'dispersity of electrophoretic mobilities' allowed a relative comparison of the …
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Insights into the structure and aggregation of lens crystallins and other aggregation-prone proteins
… conformational aspects in comparison to SEC-MALS. The method distinguished between BSA oligomers and two different monomer populations, multiple YADH monomer and tetramer conformations, and apo- and holo-BLA. The 'dispersity of electrophoretic mobilities' allowed a relative comparison of the …
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Strength Capabilities and Subjective Limits for Repetitive Manual Insertion Tasks
… a much longer period. Maximum acceptable limits (MALs) are typically derived from having participants adjust a weight, resistance, or frequency to an acceptable level. The present study evaluated a relatively new method of collecting MAL data for simple, single-digit exertions where participants …
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Disclosure Limitation in OLAP
… (2003) sowie Wixom & Watson (2001) werden erst-mals Kriterien zur Evaluation der Qualität von OLAP vorgeschlagen. Zwei (kompatible) Adaptionen des DeLone-McLean-Modells erlauben die Bewertung von OLAP einerseits und von Disclosure Limitation-Verfahren in OLAP andererseits. Im Fokus der Bewertung …
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Weather extremes in a changing climate: analyses for extreme precipitation, severe hail, and tornadoes
… days. Additionally, hail swaths with the largest MALs occur on outbreak days. Lastly, the frequency and spatial extent of environments supportive of tornado and severe hail outbreak days, utilizing reanalysis data, are investigated over a 38-year historical period. A better understanding of the …
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Characterising the effects of ACK-mediated phosphorylation on the Class IA PI3-Kinase regulatory isoforms
… with recombinant ACK. Interestingly, the SEC-MALS experiments with phosphorylated p85α and p55α showed no evidence for phosphorylation-driven p85 isoform dimerisation. Yet, further analysis suggested that the absence of detected dimerisation was likely attributed to low levels of …
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Advancing thermal field-flow fractionation for industrial polymer characterization
… preparation methods were evaluated using ThFFF-MALS and the molar mass profiles indicated that centrifugation followed by filtration was the most suitable. Next, PDMS samples with different levels of crosslinking were analyzed and the log g” distribution for the more crosslinked sample was …
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