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Showing 1 to 12 of 12 for “"MALONATES"”.
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Design, synthesis and evaluation of organocatalysts in 1,4-conjugate additions to nitroolefins and alkylidene malonates
A family of cinchona-based and thiourea pyrrolidine-based organocatalysts were synthesised and fully characterised. Their catalytic activity and selectivity in 1,4-conjugate additions involving the Michael acceptor, nitrostyrene, was evaluated. Thiourea catalysts based upon the cinchona alkaloid …
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Investigation of artificial malonyl group carriers and multifunctional cyclic scaffolds towards the mimicry of PKS
… from hydrogen-deuterium exchange experiments of malonates. The results obtained from kinetic experiments allowed us to select the more suitable artificial malonyl carriers in decarboxylative aldol-type condensations. In the second part of the thesis, the first example of a base and metal -free …
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Novel aza-arylphosphane ligands for ruthenium catalyzed anti-Markovnikov hydration of terminal alkynes
… functionalized terminal alkynes, e.g. ketones, malonates, esters. In addition, a new synthetic entry into ß-amino carbonyls has been developed by means of ruthenium-catalyzed anti-MARKOVNIKOV hydration of N-tosyl propargylamines. Finally, the first ruthenium-catalyzed anti-MARKOVNIKOV hydration …
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New axially chiral amine organocatalysts
… additions reactions between cyclic enones and malonates, with enantiomeric excesses of 24% seen using optimized conditions.
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The development and application of metal-catalyzed processes for organic synthesis
… system for the synthesis of [alpha]-aryl malonates has been developed. Aryl iodides bearing a variety of functional groups can be effectively coupled to diethyl malonate in high yields using inexpensive and widely available reagents, making this a superior method to those previously …
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APPLY LADDER OF CHEMICAL CIRCULARITY: RECYCLING OF RARE EARTH ELEMENTS RECOVERED FROM ELETRONIC WASTE AS A CATALYST IN ORGANIC REACTION.
… reaction between indoles and benzylidene malonates, employing these catalysts to achieve high reaction efficiency and selectivity. Additionally, a Diels-Alder cycloaddition was performed using chiral auxiliaries, promising results in terms of both reaction yield and enantioselectivity. The …
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Organocatalytic asymmetric mannich-type reactions: an easy approach to optically active amine derivatives
… imine precursors and non-commercially available malonates with excellent results in terms of yields and enantioselections.3 In this particular case we recorded 1 mol% of catalyst loading, very low for organocatalytic processes. Then we thought to develop a new Mannich reaction by using simpler …
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Understanding the singlet oxygen reactivity of salarin C through synthesis of a simplified macrocyclic analogue; multicomponent, enantioselective organocatalytic synthesis of tetrahydropyridazinones.
… from commercially available acid chlorides, malonates and azodicarboxylates. While attempting the oxidation of the N-N bond of the derived tetrahydropyridazinone, an unusual rearrangement to a ketene acetal lactone was also observed. This methodology could be used to construct novel …
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Syntheses of novel acyclic amino-amido ligands
… (66) from appropriately C-functionalized malonates by amidation with N,N-dimethylethylenediamine (62) followed by reduction of the respective nitro (64) and cyano (63) groups is described. The synthesis of N,N'-bis[2-(N'',N''-dimethylamino)ethyl]iminodiacetamide (73) from diethyl …
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Carbene catalyzed asymmetric nucleophilic acylations with novel triazolium salts
… addition of heterocyclic aldehydes to arylidene-malonates catalyzed by N-heterocyclic carbenes, which afforded chiral polycarbonyl compounds in good yields (>85%) and good enantioselectivities (up to 78% ee). More importantly, excellent enantiomeric excesses (up to >99% ee) were obtained after …
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Novel sulfur containing electrophiles in asymmetric organocatalysis
… (enamine-catalyzed Michael addition, addition of malonates) were impossible to perform. Moreover, our efforts to perform MBH-reactions with benzaldeyde or Henry reactions with different nitro compounds were unsuccessful. In general, alpha,beta-unsaturated sulfonates were not reactive under various …
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ΜΕΛΕΤΗ ΑΝΤΙΔΡΑΣΕΩΝ ΕΤΕΡΟΚΥΚΛΙΚΩΝ ΑΡΩΜΑΤΙΚΩΝ ΝΙΤΡΩΔΑΜΙΝΩΝ
THE NITROSATION OF 4-METHYLAMINO-1-METHYL-PYRIDINIUM PERCHLORATE IN 0.1-4.0 N PERCHLORIC ACID IS OF FIRST ORDER IN AMINE AND NITROUS ACID AND FOLLOWS THE RATEEXPRESSION: R=K3 [AMINE] [NITROUS ACID] HO. (I) THE RESPECTIVE NITROSAMINE FORMED IS EASILY DENITROSATED UNDER THE EXPERIMENTAL CONDITIONS. …