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Showing 1 to 20 of 71 for “"MALDI-Tof-mass spectrometry"”.

  1. Characterization of Oligosaccharides and Nanoparticles by MALDI-TOF Mass Spectrometry

    Guan, Bing

    … of small oligosaccharides by negative ion mode MALDI using anion attachment followed by PSD are investigated. By careful initial adjustment of the focusing mirror ratios allowing acquisition of the peaks of interest within the same PSD segment, it is possible to obtain highly reproducible …

    uno Repository record

  2. Optimizing main spectrum profiles for use in real-time MALDI-TOF mass spectrometry identification of Leptospira serovars

    Nickolyn-Martin, Jennifer E.University of Illinois at Urbana-Champaign2020

    … Laser Desorption Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) by diagnostic laboratories for microorganism identification to the species-level, MALDI-TOF MS was explored as a potential method for serovar detection and identification in leptospirosis-positive canine urine …

    uiuc Repository record

  3. Proteomic comparison of Amoxicillin resistant and susceptible periodontal Provotella Intermedia and Provotella Nigrescens clinical isolation with Matrix-Assisted Laser Disportion Ionization Time-Of-/flight mass spectrometry

    Almesbah, LatifaTemple University. Libraries2015

    … laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry, and associated analytic software for the definitive identification P. intermedia and P. nigrescens in clinical specimens, has been approved for clinical microbiology diagnostic use in the United States by the Food and …

    temple Repository record

  4. Structure-Function Relationship Studies of the Cytochrome Oxidases

    Tsatsos, Panagiota HristosUniversity of Illinois at Urbana-Champaign2015

    … anhydrase standard (molecular weight 36800). MALDI-TOF mass spectrometry analysis identified this as a single peak with a m/z of 34336.4, which is exactly twice the mass of subunit IV. It is believed that a covalent linkage of subunit IV is made.

    uiuc Repository record

  5. Towards the synthesis of ferrocene nucleic acids

    Lydon, Claire ElizabethUniversity of Birmingham2009

    … synthesis techniques, and characterised using MALDI-ToF Mass Spectrometry. CD and Tm studies were also carried out. Synthetic strategies towards chiral ferrocenes, via intermediates with groups consisting of protected alcohols or amines on each of the cyclopentadienyl rings, were also …

    birmingham Repository record

  6. DARK-PIGMENTED, AMOXICILLIN-RESISTANT, BACTERIAL SPECIES IN CHRONIC PERIODONTITIS MICROBIOTA IDENTIFIED WITH MATRIX ASSISTED LASER DESORPTION/IONIZATION TIME-OF-FLIGHT MASS SPECTROMETRY.

    Cabrera, Juan CarlosTemple University. Libraries2015

    … laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry and its associated analytic software, was recently approved for clinical microbiology diagnostic use in the United States by the United States Food and Drug Administration. This methodology is capable of definitively …

    temple Repository record

  7. Characterization of the major extrapallial fluid protein of the mollusc, Mytilus edulis: Implications for function

    Yin, Yan

    … proteins by 2-D gel electrophoresis coupled with MALDI-TOF mass spectrometry is discussed. Tropomyosin and paramyosin have been identified in the shell matrix, but no evidence for the EP protein has been found by the proteomic methods.</p><p>The post-translational modification (particularly …

    unh-thes Repository record

  8. Molecular cloning, structural characterisation and functional study of bioactive peptides from amphibian skin secretion

    Chen, YuqingQueen's University Belfast2021

    … QUB-1617, QUB-1629), and each was confirmed by MALDI-TOF mass spectrometry and RPHPLC, for mass confirmation and purification. Further studies on these three peptides were conducted, including their bioactivity profiling, structure-activity relationships and rational design analogues.

    qu-belfast Repository record

  9. Identification and Characterization of Bacterial and Bacteriophage Proteins Via Matrix-Assisted Laser Desorption Ionization (Maldi) Mass Spectrometry

    Callahan, Courtney Tenille

    … and characterization of the separated proteins (mass spectrometry). Protein analysis is an underutilized tool that can serve as a valuable alternative to DNA for the identification and characterization of microorganisms. Driven by the need to identify, characterize, and quantify proteins at ever …

    south-carolina Repository record

  10. A bioactive peptide from the skin of the Chinese Torrent Frog, <i>Amolops wuyiensis</i>

    Lu, KeleiQueen's University Belfast2017

    … laser desorption/ionisation time-of-flight (MALDI-TOF) mass spectrometry and purified by reversed-phase high performance liquid chromatography (RP-HPLC). To determine the bioactive function of Lividin-AW, a series of bioactivity assays, including antimicrobial assays, cell viability assays, a …

    qu-belfast Repository record

  11. Mass spectrometric analysis of chitooligosaccharides and their interaction with proteins

    Bahrke, SvenUniversität Potsdam

    … of the chitooligosaccharides followed by MALDI-TOF mass spectrometry allowes for the quantitation of mixtures of homologes. vMALDI LTQ multiple-stage MS is employed for quantitative sequencing of complex mixtures of heterochitooligosaccharides. Pure homologes and isomers are applied to …

    potsdam-diss Repository record

  12. A bioactive peptide, QUB-1813, from the defensive skin secretion of the Chinese Large Odorous Frog, Rana (Odorrana) livida

    Fang, QiaoyuQueen's University Belfast2017

    … cloned precursor-encoding cDNA and confirmed by MALDI-TOF mass spectrometry. It was then chemically-synthesised by solid phase Fmoc chemistry to provide sufficient material to perform bioassays. <br/>The results showed that QUB1813 possessed weak antimicrobial activity against the standard …

    qu-belfast Repository record

  13. The discovery and functional study of a bioactive peptide QUB-1418 from the defensive skin secretion of the Wuyi torrent frog (Amolops wuyiensis)

    Du, XiangqiQueen's University Belfast2020

    … laser desorption, ionisation, time-of-flight (MALDI-TOF) mass spectrometry, QUB-1418 was subjected to functional tests and it was found to have potent antibacterial activity against S. aureus(MIC= 4 μM; MBC= 8 μM), E. coli(MIC= 64 μM; MBC= 256 μM), and C. albicans(MIC= 64 μM; MBC= 64 μM). …

    qu-belfast Repository record

  14. A novel peptide QUB-2562, discovered from the skin secretion of the frog, Agalychnis annae

    Gong, RoujiaQueen's University Belfast2019

    … laser desorption ionisation, time-of-flight (MALDI-TOF) mass spectrometry was used to identify and purify peptide QUB-2562. Then QUB-2562 was tested in several biological experiments and found to inhibit the growth of S. aureus (MIC = 2 µM; MBC = 2 µM), E. coli (MIC = 4 µM; MBC = 4 µM), and C. …

    qu-belfast Repository record

  15. The functional evaluation of a bioactive peptide, QUB-1998, discovered from the skin secretion of the frog, Pelophylax nigromaculata

    Sun, WenquanQueen's University Belfast2018

    … laser desorption, ionisation, time-of-flight (MALDI-TOF) mass spectrometry, QUB-1998 was subjected to functional tests and it was found to have potent antimicrobial effects against E. coli (MIC = 16 µM; MBC = 32 µM), S. aureus (MIC = 8 µM; MBC = 32 µM), and C. albicans (MIC = 32 µM; MBC = 32 …

    qu-belfast Repository record

  16. QUB-1383, a novel bioactive peptide from the defensive skin secretion of the edible frog (Pelophylax kl. esculentus)

    Sang, MengruQueen's University Belfast2017

    … synthesis and its structure confirmed via MALDI-TOF mass spectrometry. Then the crude synthesised peptide was purified via RP-HPLC. Several bioassays including antimicrobial assays, haemolytic assays and trypsin inhibitor assays were conducted to ascertain its bioactivities. The synthetic …

    qu-belfast Repository record

  17. QUB-1951: a bioactive peptide from the skin secretion of the Chinese piebald Odorous frog, Odorrana schmackeri

    Hu, JiayiQueen's University Belfast2018

    … laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry and purified by reverse phase-high performance liquid chromatography (RP-HPLC). This synthetic peptide was then subjected to functional assays, including antimicrobial assay, trypsin inhibition assay haemolysis assay, …

    qu-belfast Repository record

  18. Evaluation of bioactivity of QUB1977 from the skin secretion of the frog, Phyllomedusa camba

    Wu, XianhuiQueen's University Belfast2017

    … peptide was isolated and identified using HPLC, MALDI-TOF mass spectrometry.<br/>The synthetic replicate exhibited a broad spectrum antimicrobial activity against Gram-positive bacteria Staphylococcus aureus, Gram-negative bacteria Escherichia coli and the yeast Candida albicans at concentrations …

    qu-belfast Repository record

  19. The discovery of a novel dermaseptin identified from the defensive skin secretion of the South American frog, Phyllomedusa sauvagii

    Zhao, YanQueen's University Belfast2017

    … laser desorption, ionisation, time-of-flight (MALDI-TOF) mass spectrometry, QUB-2593 was subjected to functional tests and it was found to have potent antimicrobial effects against E. coli (MIC = 4 µM; MBC = 32 µM), S. aureus (MIC = 32 µM; MBC = 512 µM), and C. albicans (MIC = 32 µM; MBC = 256 …

    qu-belfast Repository record

  20. Overexpression of active AKT3 induces differential binding of coregulator proteins to the estrogen receptor as a possible mechanism of Tamoxifen resistance

    Hagras, Muhammad A.2008

    … The isolated protein spots were subjected to MALDI-TOF mass spectrometry. By searching protein databases through the MASCOT website for protein identification, we have identified estrogen receptor co-regulator proteins that may play a potential role in tamoxifen resistance. Current studies are …

    u-pacific Repository record

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