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Showing 1 to 6 of 6 for “"MALDI-IMS"”.
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MALDI Mass Spectrometry Imaging for the Discovery of Prostate Carcinoma Biomarkers
… profiling of proteins in tissue sections using MALDI imaging mass spectrometry (MALDI-IMS) has the power to link molecular detail to morphological and pathological changes, enhancing the ability to identify candidates for new specific biomarkers. However, critical questions remain regarding the …
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Developing and utilizing a robust mass spectrometry-based approach to study glucose metabolism and transport in the lens
… desorption/ionization imaging mass spectrometry (MALDI-IMS) analysis of glucose uptake and metabolism in ocular lenses. Specifically, the matrix choice, tissue preparation steps and normalisation strategies were carefully optimised to glucose and its metabolites using MALDI-IMS applied to organ …
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Secondary Metabolite Production By An Endophytic Bacillus sp. from Platanus Occidentalis
… of Platanus occidentalis using a combination of MALDI-IMS, LC-MS, MS-MS, and NMR methods, by purifying nicotianamine from soy flour, and by reviewing natural product inhibitors of the hepatitis C virus (HCV). The secondary metabolite production of the endophytic B. amyloliquefaciens was …
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Biomarker identification in HIV and non-HIV related lymphomas
… biomarkers for DLBCL were determined using MALDI imaging mass spectrometry (IMS) and characterised using LCMS. The expression of one of the biomarkers, heat shock protein (Hsp) 70, was confirmed on a separate cohort of samples using immunohistochemistry. Our results indicate that the …
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Investigation of protein biomarkers in HIV positive and HIV negative associated DLBCL
… HIV and non-HIV related DLBCL were subjected to MALDI-imaging, in order to get the spatial distribution of proteins in DLBCL tissue. Proteins were extracted from tissue samples and subjected to liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) to identify proteins present in …
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Creating a Map for Surgeons: Direct Blotting Assisted Stamping of Tissue for MALDI Imaging Mass Spectrometry
MALDI imaging mass spectrometry is an attractive technique for the discovery of disease biomarkers from surgically removed tissue sections. It can provide spatial resolution and relative abundance of a wide range of biomolecules across the tissue surface. While the technology has advanced …