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Showing 1 to 20 of 443 for “"MALDI"”.
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Investigation of Primary Ion Formation Mechanisms in UV-MALDI-MS Using Excited State Dynamics of Common MALDI Matrices
… towards primary ionization mechanisms within MALDI mass spectrometry. Albeit MALDI-MS is an extensively used analytical technique, the mechanism in which primary ions are created is still under scrutiny. Two current models of primary ionization exist which claim to elucidate the ion formation …
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MATRIX-ASSISTED LASER DESORPTION/IONIZATION (MALDI) TARGET MODIFICATION FOR ENHANCED PROTEOMICS ANALYSIS AND PLASMA POLYMER CHARACTERIZATION BY MALDI MASS SPECTROMETRY
… three surface modifications are used to produce MALDI targets having reduced surface-protein binding affinity with a goal of increasing peptide/protein MALDI ion signals and lowering the limits of detection (LODs) for proteins and peptides. The second section discusses a bioselective MALDI …
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Exploring single cell neurochemistry with multimodal MALDI MS
… cell matrixassisted laser desorption/ionization (MALDI) MS to increase the amount of information we can obtain from individual mammalian brain cells. We first developed an open source software, that simplifies microscopy-guided MALDI MS measurements and subsequent correlation of data from …
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Development of Amine Containing Polymer Modified MALDI Targets for Complex Peptide and Protein Mixture Fractionation Prior to MALDI Mass Spectrometry Analysis
… OF AMINE CONTAINING POLYMERIC MODIFIED MALDI TARGET SUBSTRATES FOR COMPLEX MIXTURE FRACTIONATION OF PEPTIDE AND PROTEIN MIXTURES PRIOR TO MALDI MASS SPECTROMETRY ANALYSIS MAJOR PROFESSOR: Dr. Gary Kinsel The focus of this dissertation is the synthesis, development and application of the …
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Sample preparation methodologies for MALDI-MS imaging and related topics.
The diverse applications of MALDI MSI are explored in this thesis with an emphasis on the sample preparation procedure and method development for small molecule analysis for a range of samples. The two main themes that have been focussed on are the pharmaceutical and metabolomic applications of …
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Imaging the distribution of agrochemicals in plants by MALDI-MSI.
… few agrochemicals can be studied in this way.MALDI is a highly adaptable soft ionisation technique that was established in the late 1980's through the developmental research of Tanaka and Hillenkamp. The versatility of MALDI-MS has been extended in recent years with the advent of protein …
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Characterization of Oligosaccharides and Nanoparticles by MALDI-TOF Mass Spectrometry
… of small oligosaccharides by negative ion mode MALDI using anion attachment followed by PSD are investigated. By careful initial adjustment of the focusing mirror ratios allowing acquisition of the peaks of interest within the same PSD segment, it is possible to obtain highly reproducible …
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DEVELOPMENT OF IONIC POLYMER NANOBRUSHES WITH APPLICATION IN MALDI-MS
… Laser Desorption Ionization Mass Spectroscopy - MALDI-MS.
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Synthesis and Maldi-Ms Characterization of New Ruthenium Sulfide Clusters
… heterocubane structure, was identified using MALDI-MS and IR spectroscopy.
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Multiscale MALDI mass spectrometry for tissue, cellular, and subcellular lipidomics
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-20 without embargo terms
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Detection and imaging of pharmaceutical compounds in skin by MALDI-MS.
… compounds in porcine epidermal tissue by MALDI-TOF-MS is presented. Direct analysis of fresh tissue sections was compared with the analysis of tissue imprints formed by blotting onto a variety of substrates. The samples were coated with matrix material by a prototype electrospray …
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MALDI Mass Spectrometry Imaging for the Discovery of Prostate Carcinoma Biomarkers
… profiling of proteins in tissue sections using MALDI imaging mass spectrometry (MALDI-IMS) has the power to link molecular detail to morphological and pathological changes, enhancing the ability to identify candidates for new specific biomarkers. However, critical questions remain regarding the …
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MALDI-TOF MS Data Processing Using Wavelets, Splines and Clustering Techniques.
… matrix assisted laser desorption/ionization (MALDI) time of flight (TOF), is emerging as a leading technique in the proteomics revolution. It can be used to find disease-related protein patterns in mixtures of proteins derived from easily obtained samples. In this paper, a novel algorithm for …
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Characterization of AP-MALDI and ESI for a differential mobility spectrometer
… Matrix Assisted Laser Desorption Ionization (AP-MALDI). In addition to system development, Fourier transform and decision tree analyses were explored as alternatives to lead-cluster mapping and genetic algorithms for analyzing and classifying data produced by the systems for large biomolecules. …
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Gold compact disc appended Tröger’s base scaffolds as MALDI-TOF biodetection probes
… detection of these biological interactions via MALDI-TOF spectrometry will be probed. The (+)-biotin / streptavidin interaction will be used as a model study for these purposes with the ambition to develop this further with humanitarian and military applications. The V-shape and 90˚ angle of …
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Characterization of A-type Proanthocyanidins in Peanut Skins Using MALDI-TOF MS
… ionization-time of flight mass spectrometry (MALDI-TOF MS). Many similarities were found in the proanthocyanidin composition of cranberries and peanut skins. New oligomeric and polymeric proanthocyanidins in peanut skins, including heteroproanthocyanidins and proanthocyanidins with sugar …
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Stationäre und zeitaufgelöste Photolumineszenz-Spektroskopie zur Analyse ultraschneller Photoreaktionen in MALDI- und Solarzellenproben
… Analyse ultraschneller Photoreaktionen in festen MALDI- und Solarzellenproben wurden stationäre und zeitaufgelöste Messungen der Photolumineszenz (PL) durchgeführt. In den Messungen an reinen Zimtsäureproben wurde erstmals eine PL-Signatur beobachtet, die durch eine auf der ps- bzw. fs-Zeitskala …
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The use of MALDI-MS for imaging drug disposition in respiratory disease models.
… desorption/ionisation-mass spectrometry imaging (MALDI-MSI) has been extensively applied to monitoring the distribution of pharmaceutical compounds in tissues. The main aim of the work reported in this thesis is to monitor the distribution of respiratory compounds in the lungs following inhaled …
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TARGET MODIFICATION FOR ENHANCED PERFORMANCE MATRIX ASSISTED LASER DESORPTION IONIZATION (MALDI) MASS SPECTROMETRY
… MATRIX ASSISTED LASER DESORPTION IONIZATION (MALDI) MASS SPECTROMETRY MAJOR PROFESSOR: Dr. Gary R Kinsel MALDI MS, a powerful tool for the analysis of biomolecules, has undergone major advancement in instrumentation to yield improvements in robustness, sensitivity and throughput since its …
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