Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"MALAT1"”.
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Small molecule-degrader conjugates for MALAT1 triplex degradation
… a specific, long non-coding RNA sequence called MALAT1. Due to its uncommon triple helix structure, this transcript has a noteworthy stability, with a half-life of up to 15 hours, resulting in its build-up in the cell environment. This work details my efforts in the design and synthesis of …
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The Long Non-coding RNA Malat1 Regulates Inflammatory Cytokine Production in Chronic Diabetic Complications
We examined the role of MALAT1, a highly conserved nuclear lncRNA, in chronic diabetic complications affecting the heart and kidneys, specifically with respect to inflammatory cytokine production. Endothelial cells, exposed to various glucose levels, and MALAT1 knockout mice and controls, with or …
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Cardiac repair post-myocardial infarction: Roles of the primary cilium and the long non-coding RNA Malat1
… Furthermore, the long non-coding RNA (lncRNA) Malat1 is not only known to regulate EMT, but also mitigates cell death from injury. Little is known about the roles of Wt1, primary cilia, and Malat1 in relation to neonatal cardiac regeneration and adult cardiac repair post-MI. The aim of thesis …
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Discovery and analysis of long noncoding RNAs in gene expression control and cell cycle progression
… of a mutual regulation between lncRNA MALAT1 and its natural antisense transcript TALAM1, followed by the identification and functional characterization of lncRNAs involved in cell cycle progression. The mutual regulation between MALAT1 and TALAM1 presents a novel feed-forward positive …
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Role of long non-coding RNAs in breast cancer progression
… function of majority of these lncRNAs. MALAT1 (metastasis associated lung adenocarcinoma transcript1) is a lncRNA which its expression is deregulated in various tumors, including breast cancer. However, the significance of such abnormal expression is yet to be fully understood. In this …
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LncRNA and circRNA expression profiles in tissues and serum exosomes of colorectal cancer patients and cell lines
… 8 ncRNAs (CCAT1, CCAT2, CDR1AS, HOTAIR, MALAT1, TUG1, UCA1 and ZEB2AS1) differentially expressed (DE) in tissues and 3 ncRNAs (circ16, TUG1 and UCA1) DE in serum exosomes. Through gene ontology analysis we verified the involvement of DE ncRNAs in pathways associated with tumor …
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Towards A Unified Model Of Sperm Chromatin Structure
… with late spermatogenic transcription. Malat1, a well-known nuclear non-coding RNAs, was relatively abundant within the intra-nuclear compartment of the gamete although enriched within the sperm extra-nuclear compartment. If these transcript are localized to the condensed sperm nucleus …
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RNA in the nucleus: insight into location and biological function
… nuclear body associated RNAs including SNHG1, MALAT1, NEAT1 and XIST. 80 – 95% of the DNA targets of caRNA were observed to be connected to the loci of RNA transcription, 1-2% were observed to be on the same chromosome but distal to the loci of RNA transcription and about 5 – 10 % of the DNA …
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The role of RNAs and extracellular vesicles in the radiation response
… analysis a functional study of the genes ANP32B, MALAT1, NET1, HSP90AA1 and NCL was performed based upon their upregulation in 2 Gy EVs. Knockdown of some of these genes resulted in changes in the DNA damage response observed in directly irradiated and bystander cells, suggesting that the RNAs …
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Development of a pericyte-based strategy to recover aged skeletal muscle after disuse
… associated lung adenocarcinoma transcript 1 (Malat1, also known as Neat2) specifically in pericytes suggested disruption to antioxidant production. To test this hypothesis, pericytes were obtained from healthy or immobilized skeletal muscle and exposed to a hydrogen peroxide load in vitro. …
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Development of Oligonucleotide-directed proximity-interactome MAPping (O-MAP), for characterizing RNA-protein interactions and higher order subnuclear architecture in situ
… as X inactive specific transcript (XIST) and MALAT1, are thought to have an architectural role in organizing subnuclear Barr bodies and nuclear speckles for gene regulation. However, studying specific RNA and their protein interactomes is challenging by conventional methods. Most approaches …
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ncRNA come biomarcatori e regolatori molecolari del cancro alla prostata
… selezionato validato e proposto 3 lncRNA (MALAT1, PCA3, PCAT18), un mRNA (KLK3) e 8 microRNA (miR-27b-3p, miR-30a-3p, miR-30a-5p, miR-30b-5p, miR-30c-5p, miR-107, miR-125b-5p, miR-574-3p) come potenziali biomarcatori per il PCa, in grado anche di discriminare i pazienti affetti da cancro da …