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Showing 1 to 8 of 8 for “"MAGL"”.
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The Role of MAGL Inhibition in Nicotine Withdrawal and Reward
ROLE OF MAGL INHIBITION IN NICOTINE WITHDRAWAL AND REWARD. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. by Pretal Ishvarlal Patel Muldoon Director: M. Imad Damaj, PhD Professor, Department of …
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Ghrelin, Cannabinoids, and Motivation: Increased Food Motivation on Progressive Ratio Paradigm Through MAGL/FAAH Inhibition in a Rat Model
… infusion of cannabinoid degrading enzymes (MAGL/FAAH) inhibitors (MJN110/PF-00457845), followed by ghrelin. Next, we examined the protein level of cannabinoid related enzymes in the VTA following an injection of ghrelin using western blotting. Our results show a significant increase in …
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Targeting the Endocannabinoid System to Reduce Inflammatory Pain
… hydrolase (FAAH) and monoacylglycerol lipase (MAGL), respectively. Selective inhibition of either enzyme elevates CNS levels of the appropriate endocannabinoid and produces analgesic effects with fewer psychomimetic side effects than Δ9-tetrahydrocannabinol (THC), the primary active constituent …
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Synergistic inhibition of cyclooxygenases and monoacylglycerol lipase in neuropathic pain
… of inhibiting both monoacylglycerol lipase (MAGL) and cyclooxygenase enzymes. Mice subjected to the chronic constriction injury (CCI) model of neuropathic pain were administered either the MAGL inhibitor, JZL184 (1-40 mg/kg, i.p.) or the nonselective COX inhibitor diclofenac sodium (1-100 …
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Mitotic homologous recombination at engineered repeats in S. cerevisiae and in novel transgenic mice
… alkylated bases by DNA glycosylases, such as the Magl 3-methyladenine (3MeA) DNA glycosylase, initiates the base excision repair (BER) pathway. To investigate the molecular basis for methylation-induced homologous recombination in S. cerevisiae, intrachromosomal recombination was measured under …
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Mediadores lipídicos generados a partir del ácido fosfatídico : rol en la señalización nuclear en el sistema nervioso central
… lipasa (DAGL), monoacilglicerol lipasa (MAGL), fosfolipasa A para PA (PA-‐ 2PLA), lisofosfatidato fosfohidrolasa (LPAPasa) y de lisofosfatidato fosfolipasa (LPAasa). Se demostró que el PA en el núcleo puede degradar-se por dos vías distintas, sin embargo, la vía activa o predomi-nante en …
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Cannabinoid Modulation of Reinforcement Maintained by Stimulation of the Medial Forebrain Bundle in C57Bl/6J Mice
… inhibitor, PF-3845, the monoacylglycerol lipase (MAGL) inhibitor JZL184, and the combined FAAH/MAGL inhibitor SA-57 in ICSS of the medial forebrain bundle in C57BL/6 mice. Additionally, we assessed the psychomotor stimulant cocaine as a positive control to facilitate ICSS. These studies were …
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I "Gradi di san Girolamo" in due inediti testimoni settentrionali (Siena, Biblioteca Comunale degli Intronati, I.II.37 e Venezia, Biblioteca Nazionale Marciana, It. I.14 [5173])
… (mss. Florence, Biblioteca Nazionale Centrale, Magl. VIII. 1282, Verona, Biblioteca Civica, n. 2098-2099). This is a relevant find, as it confirms the enormous fortune that befell the Gradi, for which more than forty manuscript witnesses are known so far. I have also included an analysis of the …