Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 133 for “"MAGE"”.
-
Defining the functional role of MAGE-C1 in Multiple Myeloma
… elucidating the function of melanoma antigen (MAGE) protein-C1 (MAGE-C1) in multiple myeloma, this project aimed to firstly establish the suitability of culture cell line RPMI-8226 as an in vitro multiple myeloma model. Additionally, the project aimed to establish relevant reagents and …
-
Exploration of methods for many-site genome editing with MAGE
… genomic changes requires specialized techniques. MAGE is well-suited to this task, being highly amenable to multiplexing and having low time and resource costs per site. MAGE has been used as a first stage in recoding efforts, converting small clusters of sites in separate strains to be combined …
-
EMMA2 : a MAGE-compliant system for the analysis of microarray data in integrated functional genomics
… About a Microarray Experiment (MIAME), the MAGE-ML format for data interchange, and ontologies, have been made. The existing software systems for microarray data analysis have only rudimentary implementations of the mentioned standards and are hard to extend. The EMMA2 software has been …
-
The Cancer Specific Ubiquitin Ligase MAGE-A3/6-TRIM28 Drives Tumorigenesis by Ubiquitination and Proteasomal Degradation of AMPK
The genes MAGE-A3 and MAGE-A6 (MAGE-A3/6) have a unique expression pattern in which they are normally expressed in the adult testis but are aberrantly expressed in cancer. It is known that when expressed in cancer, MAGE-A3/6 is a negative prognostic indicator and cancer cells are dependent on it …
-
Myelin Gene Expression: Implications for Alcohol Abuse and Dependence
… differential myelin-associated gene expression (MAGE) in medial prefrontal cortex (PFC) as one potential mechanism influencing acute ethanol behaviors between C57BL/6J (B6) and DBA/2J (D2) mice. Our laboratory and others have also shown MAGE is reduced in PFC of alcoholics. Herein, I have …
-
Translational Repression of G3BP in Cancer and Germ Cells Suppresses Stress Granules and Enhances Stress Tolerance
Melanoma antigen (MAGE) genes are conserved in all eukaryotes and encode for proteins sharing a common MAGE homology domain. Although only a single MAGE gene exists in lower eukaryotes, the MAGE family rapidly expanded in eutherians and consists of more than 50 highly conserved genes in humans. A …
-
Engineering novel antibody-based molecules to probe the role of the immunoglobulin hinge and generate a potential cancer vaccine
… to the tumour associated cancer-testis antigen, MAGE-A, were generated and tested. Such vaccines are designed to promote formation of immune complexes, which are preferentially taken up by dendritic cells via their FcRn receptors, with the aim of stimulating a strong anti-tumour immune response. …
-
Examining Adolescent Daughters' and their Parents' Implicit Math-Gender Stereotypes
… (N=415) included adolescent girls (N=185, Mage=17) and at least one parent (N=230, Mage =49). Implicit math-gender stereotyping was measured using an IAT (Greenwald et al., 1998), and explicit stereotyping, math attitudes and math ability were measured using self-reports. Daughters and …
-
Comparing motives, goals and weight training behaviours of competitive and recreational weight trainers: An application of organismic integration theory and goal contents theory
… from a purposive sample of competitive (n = 177; Mage = 30.86; SDage = 11.35) and recreational (n = 196; Mage = 21.97; SDage = 6.05) weight trainers using a cross-sectional, non-experimental design. Participants completed the Behavioural Regulation in Exercise Questionnaire-2R, Exercise …
-
The identification of NRAGE
… with a large family of tumour antigens known as MAGE (melanoma associated antigens). This newly identified member of the MAGE family, which was later named NRAGE, exhibited some unique characteristics that suggested for the first time a role in normal cellular physiology for this protein family. …
-
Positive Body Image Among Female Emerging Adults: A Mixed Methods Design
… the importance of considering positive body image (e.g., Swami, Hadji-Michael, & Furnham, 2008) that is not simply the absence of negative body image, but also the extent to which one appreciates and accepts one’s body as a whole (Avalos et al., 2005). Using a mixed-methods design, I sought to …
-
A Longitudinal Person-Centered Examination of Affinity for Aloneness Among Children and Adolescents
… study of children (N = 605, 47.76% female, Mage = 9.29 years) and early adolescents (N = 596, 51.51% female, Mage = 12.20 years) was to identify distinct groups based on responses to AFA and SA survey measures, to examine transitions between these groups over time, and to assess group …
-
Parenting and internalizing symptoms in early adolescence: The moderating role of vagal tone
… adolescents (53% boys; 57% European American; Mage = 11.05 years, SD = .33) and their mothers (Mage = 41.25 years, SD = 6.22; 96.0% biological). At Time 2 (6th grade; fall after middle school transition), 89 adolescents and their mothers returned. To address study aims, a multi-informant, …
-
Functional Analysis of KAP1 Requirements for HIV-1 Transcription and Latency Reactivation
… system. I also identified a potential co-factor MAGE-D2 from previous biochemical and genetic screens that interacts with KAP1. MAGE-D2 mimics KAP1s ability to activate HIV-1 latency reactivation in response to stimulation suggesting they form a complex to regulate the proviral genome. Together, …
-
Parental Racial Socialization and Emotion Dysregulation: Associations to Internalizing Symptoms & Sleep Difficulties Among Black Youth
… 100 Black youth ages 7-16 years (N = 100; Mage = 11.77 years; SDage = 2.64; 73% male) and their primary caregivers (Mage = 43.57 years; range = 28-73 years; SDage = 7.75; 91% female; 82% biological mothers) were recruited nationwide to complete a battery of self- and caregiver-report …
-
Adolescents' and mothers' affect during their daily interactions: an examination in the United States and China
… mothers and their children (n = 39 girls, Mage = 12.88 years) and 71 Chinese mothers and their children (n = 35 girls, Mage = 12.73 years), I found that Chinese adolescents consistently experienced less intense emotions – both positive and negative – than did European Americans. The present …
-
Emotion Regulation: Is it More Taxing for Adolescents than for Adults?
… 184 participants between the ages of 14 and 17 (Mage = 15.7, SD = 1.1), and 22 and 30 (Mage = 25.7, SD = 2.3) took part in the study. Overall, emotion elicitation interfered with performance on the N-back task in both age groups. As predicted, adolescents’ performance was more impaired than …
-
Towards a Unified Framework for Visual Recognition and Generation via Masked Generative Modeling
… across various applications. We will begin with MAGE, a novel framework that unifies image generation and recognition while achieving state-ofthe-art performance on both tasks. We then extend it into vision-language multi-modal training through ITIT, which utilizes unpaired image and text data to …
Page 1 of 7