Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"MACPF"”.
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Components of the Membrane Attack Complex (Mac) of Human Complement: Functional Studies of Their Macpf Domains
… N and C terminal modules and a central MACPF domain named for sequence similarity between the MAC family of proteins and perforin, a self-polymerizing protein released from cytotoxic T- lymphocytes.</p> <p>The first aim was to express and characterize MACPF domains of C6 and C7. Based on …
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Investigating NLR-mediated immunity and Pseudomonas syringae effector interactions with two MACPF domain proteins in Arabidopsis thaliana.
… are detected. MEMBRANE ATTACK COMPLEX/PERFORIN (MACPF) proteins are well known agents of defense in the mammalian immune system, though the exact role of this protein family in plants has not been established. Mutations in two of the four MACPF domain proteins encoded in Arabidopsis thaliana …
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Cholesterol-Dependent Cytolysins and Perforin: Similar Pore-Forming Mechanisms in Pathogenic Attack and Human Immune Defense
MACPF/CDCs proteins are a huge family of pore-forming proteins present from the bacteria to the human genera. Cholesterol-dependent cytolysins (CDCs) are a family of toxins that participate in bacterial infection pathway at the membrane level. Great interest in this family is due to their …
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Human Complement Protein C8: Crystal Structure and Analysis of Binding Interactions
… to the membrane attack complex/perforin (MACPF) domain. The role of C8 within the MAC is to initiate formation of a transmembrane pore consisting of 12-18 molecules of C9.
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Molecular Interactions of Human C9: The Pore Forming Protein of the Complement System
… called the membrane attack complex/perforin (MACPF) domain. A distinguishing feature of C9, compared to the other MAC family members, is its ability to self-polymerize. C9 polymerization may occur during MAC formation or in-solution in the absence of C5b-8, the latter is referred to as "poly …
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The role of a pore-forming protein, Mpeg1, in cytosolic import
… member of the membrane attack complex/perforin (MACPF) superfamily. We find that DCs deficient in Mpeg1 are less efficient in their ability to import saporin into the cytosol, and that the activity of Mpeg1 is regulated by low pH and potentially proteolytic cleavage. Furthermore, expression of …
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Deciphering the regulation of perforin-2-mediated endocytic escape in dendritic cells
… attack complex and perforin superfamily (MACPF) and, similar to perforin and complement, can form oligomeric pores on liposomes *in vitro*. However, the regulation of perforin-2 pore formation in the context of endocytic escape *in vivo* is still poorly understood. The aim of my PhD …