Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"M2e"”.
-
Design and production of a candidate universal influenza A vaccine in Nicotiana benthamiana plants
… acid extracellular domain of the M2 protein (M2e) is highly conserved among different influenza A strains and thus it seems like an ideal candidate for a universal influenza vaccine. However, due to its small size, it is a poor immunogen when used on its own. The aim of this project was to …
-
Tailored influenza virus vaccines for both the young and old: Vaccine Efficacy of Whole Inactivated Vaccines bearing Immunomodulatory Adjuvants or Multimeric peptides
… In addition, we tested whether a multimeric M2e peptide presented on WIV can serve to enhance immunogenicity and augment protective efficacy of whole virus vaccines. Our panel of cytokines includes IL-2, IL-4, IL-12, IL-23, and Flt3L as well as the multimeric M2e peptide, all fused to the …
-
Development of an Antibiotic Resistance Free Bivalent Vaccine Against Swine Brucellosis and Swine Influenza
… HA, NP and ectodomain of matrix protein M2e, were not found to be expressing even after optimizing their codon usage to suit Brucella tRNA preference. However, RT-PCR showed that the influenza genes mRNA were produced. In conclusion, this dissertation describes the construction of an …
-
Development of a Novel Vaccine Adjuvant and Delivery System for Cancer and Influenza
… In Chapter V, Influenza subunit antigens (HA and M2e) loaded InAc microparticles immunization showed 100 % protection in vaccinated mice after lethal challenge of influenza virus. In conclusion, we have developed a novel polymer based vaccine adjuvant and delivery system. The main innovation of …