Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"M2 polarization"”.
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M2 Polarization and Pro-Fibrotic Transition of Lupus Nephritis Macrophages
… IL-6, and TNF-α, whereas alternatively activated M2 macrophages support immune regulation and tissue repair processes. However, in LN, increased infiltration of CD163⁺ M2 macrophages is associated with disease severity and fibrotic remodeling, suggesting that sustained reparative signaling may …
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Dissecting the Role of Hedgehog Signaling in Tumor-associated Macrophages and Immunosuppression in the Tumor Microenvironment
… M1 phenotype and the anti-inflammatory M2 phenotype. These M2 polarized tumor-associated macrophages (TAMs) are known to suppress immune responses and promote neoplastic progression. We sought to gain insights into the regulation of TAM functions and mechanisms by which TAMs exert …
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Runx2 and Vascular Calcification
… of Runx2 on development of atherosclerosis and polarization of lesional macrophages. Removal of Runx2 did not affect monocyte/macrophage recruitment and atherosclerotic lesion size. Within lesions, we observed a strong shift in macrophage polarization toward an M2 polarization in atherosclerotic …
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Engineering the tumor microenvironment using microfluidics : effects of cell-cell interactions and endothelial barrier function on tumor cell intravasation
… of macrophage secreted factors and M1/M2 polarization status, identified that blocking macrophage-secreted TNF-a restored endothelial permeability and reduced tumor cell intravasation. In agreement with these results, we also found that the number and dynamics of tumor-endothelial …
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Dissecting NAMPT Signaling Pathways in Beige Adipocyte Development, Impairment and Maintenance
… NAMPT (eNAMPT) and enrichment of IL-10–producing M2 macrophages in BAT; in vitro, eNAMPT promotes IL-10–dependent M2 polarization. Collectively, this work identifies NAMPT as a central regulator of thermogenic adipocyte competence by constraining ER stress in aging progenitors, sustaining …
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The Role of The Hypoxia-Inducible Factor 2 In Pancreatic Cancer: Mechanisms of Tumor Immunosuppression and Intestinal Radioprotection
… significantly reduced macrophage chemotaxis and M2 polarization, and improved responses to checkpoint immunotherapy in two syngeneic mouse models. Together, these data suggest that stromal HIF2 is an essential component of PDAC and is a druggable therapeutic target that could relieve TME …
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Tumor microenvironmental control of metastasis : effects of the immune cells and physical forces on cell migration
… IF polarizes macrophages toward a pro-metastatic M2 phenotype via integrin/Src-dependent STAT3/6 activation. Since IF emanates from tumor core to stromal tissue surrounding the tumor, these results suggest that IF can promote metastasis by not only recruiting macrophages from stroma into tumor, …
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Characterization of interleukin-4 induced gene-1 (IL-4I1) as a host immunoregulator to cutaneous leishmaniasis in cell based models
… (M1) and Alternatively-Activated (M2) macrophages. Each are associated with a certain immune response; in the context of cutaneous leishmaniasis caused by infection with Leishmania major. Specifically, M1 macrophages allow for disease control through stimulation of cytokines such as …
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Contribution of the Microenvironment in Bone Resident Cancer: the Role of Thrombospondin-1 in Bone and Risk Loci Contributing to Multiple Myeloma
… KaLwRij macrophages had enhanced expression of polarization markers, suggesting that they are pre-activated under homeostatic conditions. Further, we found that KaLwRij macrophages stimulated to a pro-tumorigenic M2 polarization promoted 5TG myeloma tumor growth more than B6 control macrophages …
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Human immunodeficiency virus (HIV)-mediated cardiac fibrosis: implication of cellular immunomodulation and cytokine profile alterations
… (macrophage type 1 (M1) and macrophage type 2 (M2)) and circulating fibrocyte subsets (CD34+, collagen 1 [COL1+]). We further examined how these immune and profibrotic parameters relate to (i) classical markers of HIV progression (CD4 count, viral load, immune activation); (ii) cardiometabolic …