Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"M2 macrophages"”.
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Macrophage Polarization (M1/M2) and its Role in Wnt5a Secretion/Expression in Atherosclerosis
<p>Macrophages play an important role in the formation of atherosclerotic lesions and their progression. The presence of M1 and M2 macrophages in human atherosclerotic lesions has been suggested. Wnt5a is a noncanonical member of the wingless family of proteins that is expressed in human …
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The impact of Wnt5a signaling and tumor associated macrophages in breast cancer
… a beneficial effect of Wnt5a in breast cancer. Macrophages are part of the innate immune system and they can differentiate into tumoricidal pro-inflammatory M1 macrophages or anti-inflammatory M2 macrophages. The anti-inflammatory M2 macrophages will limit pro-inflammatory activity that in …
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An Investigation into the Effects of Macrophage Polarisation on Interleukin-1 Expression
Macrophages are innate immune cells characterised by functional heterogeneity and plasticity. The prevailing dogma divides macrophages into two opposing subtypes: the pro-inflammatory M1 and anti-inflammatory M2 macrophages. Macrophages are also the main cell type that produces two powerful …
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Developing Novel Therapies Targeting the Tumor Microenvironment of Aggressive Breast Cancer
… pathway suppresses IBC tumor growth and reduces M2 macrophage populations in various mouse models. Mechanistically, AXL facilitates the polarization of M2 macrophages and enhances the expression of immunosuppressive molecules and chemokines through the mediation of the transcription factor STAT6, …
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Role of Macrophages in Ocular Surface Fibrosis
… activation and polarization and whether macrophages could cause the transdifferentiation of ocular surface fibroblasts into myofibroblasts, thus contributing to oGVHD-associated fibrosis.</p> <p>Bone marrow cells were cultured in M-CSF to obtain M0 macrophages, which were subsequently …
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The Impacts of Sex and Myogenic Cell Transplantation on Collateral Capillary Arteriogenesis
… myogenic cells increase arteriogenesis, and macrophages are an essential regulator of arteriogenesis, we also tested the hypothesis that myogenic cells would increase macrophage content.<strong> </strong>Macrophage number increased with ligation, but there was no difference in macrophage …
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Characterization of interleukin-4 induced gene-1 (IL-4I1) as a host immunoregulator to cutaneous leishmaniasis in cell based models
… (M1) and Alternatively-Activated (M2) macrophages. Each are associated with a certain immune response; in the context of cutaneous leishmaniasis caused by infection with Leishmania major. Specifically, M1 macrophages allow for disease control through stimulation of cytokines such as …
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Functional properties of galectin-3. Beyond the sugar binding.
… often supported by the activity of different macrophages. Proteins from galectin family were found to contribute to disease pathophysiology. Therefore, there is an intensive interest in understanding different galectin functions. The aim of this thesis was to pin-point specific galectin-3 …
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Crosstalk between colorectal cancer cells and tumour-associated macrophages
… Tumour cells are able to recruit macrophages and change their behaviour. These tumour-associated macrophages (TAMs) were of the M2 phenotype (CD206+). In CRC patient tissues and xenografts from mouse model, presence of increased amount of M2 macrophages was observed. M2 macrophages …
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Exosomal Communication By Metastatic Osteosarcoma Cells Modulates Alveolar Macrophages to An M2 Tumor-Promoting Phenotype and Inhibits Tumoricidal Functions
… of tumor promoting immunosuppressive M2<em> </em>macrophages in the metastases and poor patient survival. By contrast, M1<em></em>macrophage predominance correlates with longer survival. M2 macrophages can be induced by various stimuli in the tumor microenvironment, including exosomes, …
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Recruitment of monocytes to the pre-ovulatory ovary
… the tissues they differentiate into either M1 macrophages, to further promote inflammation, or M2 macrophages to stimulate corpus luteum development. Studies have shown that animals deficient of these subsets of monocytes and macrophages have reduced rates of ovulation. Several other leukocyte …
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The role of the inositol phosphatase, SHIP, in the innate immune response to Salmonella Typhimurium
… animals, and analysis of supernatants taken from M2 bone marrow derived macrophages correlated with this data. M2 macrophages were the predominant population in vivo during both oral and intraperitoneal infections. Because M2 macrophages are poor defenders against bacterial infection, these data …
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M2 Polarization and Pro-Fibrotic Transition of Lupus Nephritis Macrophages
… leads to progressive kidney injury and fibrosis. Macrophages play a central role in this process because of their functional plasticity and ability to respond to environmental cues. Classically activated M1 macrophages promote inflammation through cytokines such as IL-1β, IL-6, and TNF-α, whereas …
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Targeting the adenosine pathway reshapes a myeloid-dependent tumour microenvironment in pancreatic ductal adenocarcinoma. An opportunity for therapeutic intervention
… areas, enriched for myeloid infiltration. M2 macrophages among other myeloid populations, highly expressed the Adora2a receptor, particularly in the IOT-resistant model. Targeting the adenosine pathway (Adoi) delayed tumour growth and reduced the occurrence of lung metastases in …
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Combating HIV-1 by Targeting Drug Efflux Transporters on the Macrophage Reservoir
… antiretroviral drug therapy (ART). Infected macrophages, which represent a long-term viral reservoir have been shown to lead to viral rebound independently. In response to the environmental stimuli, macrophages can be polarized into different phenotypes: the pro-inflammatory M1 and the …
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Role of Macrophage Subsets in CD8+ T Cell Dysfunction in Chronic HCV Infection
… CD8+ T cells. Infiltrating monocyte-derived macrophages contribute to a micro- environment that could impact CD8+T cells trafficking through the liver. Macrophages can differentiate into pro-inflammatory (M1) and anti-inflammatory (M2a, M2b, and M2c) subsets. Whether macrophage subset …
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Characterization of Immune Cell Populations in White Adipose Tissue of Wild Type and Bovine Growth Hormone Transgenic Mice
… including a variety of immune cells such as macrophages, T cells, Natural Killer T cells (NK), and depot specific differences in cellular composition and endocrine output. Growth hormone (GH) has been shown to impact immune function as well as adiposity. The immune cell population, within WAT …
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Cellular plasticity in white adipose tissue: in vivo identification of bipotent adipocyte progenitors in adult white adipose tissue
… demonstrated that ADRB3 activation recruited M2 macrophage to form crown-like structures in epididymal WAT and M2 macrophages released OPN and PDGFC to induce progenitor migration and proliferation. Progenitor activation was dependent on PDGF signaling and attenuated by pharmacologic …
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Identification of macrophage phenotypes and evaluation of their role in the immunopathogenesis in animal model of Behçet’s disease
… activated (M1) and alternatively activated (M2) macrophages. In a herpes simplex virus (HSV)-induced BD mouse model, it has confirmed the abundant expression of the M1 phenotype (CD16/32) compared to the M2 phenotype(CD23). For M1/M2 phenotypic transformation in vivo normal mice, recombinant …
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Modulation of macrophage and epithelial cell immune defences by probiotic bacteria: immune stimulation versus suppression
… These include, tolerance, associated with an M2-, regulatory macrophage phenotype and inflammatory activation with an M1-like phenotype. The cross-link between mucosal tolerance and inflammatory cytokine suppression, and augmentation of IL-10 production in the gut relate to endotoxin …
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