Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"M2 macrophage"”.
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LPS from subgingival plaque and the periodontal pathogen Porphyromonas gingivalis, its effect on M1 and M2 macrophage responses and potential as a biomarker
… pattern that instigates an immune response from macrophages (MΦ), key orchestrators of host immune response. Repetitive exposure Is also demonstrated to induce a quiescent state known as endotoxin tolerance, thought to be a protective mechanism but which may also confer protective benefits to …
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Characteristics of decidual macrophages and Hofbauer cells in placentas of HIV positive women on antiretroviral therapy
Macrophages are the most abundant immune cells at the maternal-foetal interface of term placentas. They play a role in regulating pregnancy, promoting immunological tolerance, and maintaining a homeostatic environment crucial for foetal development. Numerous studies have reported the dysregulation …
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Cellular plasticity in white adipose tissue: in vivo identification of bipotent adipocyte progenitors in adult white adipose tissue
… demonstrated that ADRB3 activation recruited M2 macrophage to form crown-like structures in epididymal WAT and M2 macrophages released OPN and PDGFC to induce progenitor migration and proliferation. Progenitor activation was dependent on PDGF signaling and attenuated by pharmacologic …
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Transient receptor potential vanilloid 1 exhibits neuroprotective effects in LPS-induced dopaminergic neuronal death in the suabstantia nigra in vivo.
… ROS while CAP increases Arginase 1 and CD206, M2 macrophage markers. In addition, CAP protected nigral DA neurons from LPS-induced neurotoxicity. This neuroprotective effect was reversed by capsazepine, a TRPV1 antagonist, indicative of TRPV1 involvement. However CAP could not block the …
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Developing Novel Therapies Targeting the Tumor Microenvironment of Aggressive Breast Cancer
… pathway suppresses IBC tumor growth and reduces M2 macrophage populations in various mouse models. Mechanistically, AXL facilitates the polarization of M2 macrophages and enhances the expression of immunosuppressive molecules and chemokines through the mediation of the transcription factor STAT6, …
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Identification of macrophage phenotypes and evaluation of their role in the immunopathogenesis in animal model of Behçet’s disease
… the development of this disease remains unclear. Macrophage phenotypes are markedly heterogeneous and include classically activated (M1) and alternatively activated (M2) macrophages. In a herpes simplex virus (HSV)-induced BD mouse model, it has confirmed the abundant expression of the M1 …
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Transcriptomic profiling of macrophage polarization
Macrophages perform a wide variety of crucial, and sometimes contradictory, functions. While “pro-inflammatory” activities like fighting off infections and “anti-inflammatory” activities like wound-healing traditionally have been attributed to M1 and M2 macrophage subsets, studies of macrophages in …
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The role of the inositol phosphatase, SHIP, in the innate immune response to Salmonella Typhimurium
… animals, and analysis of supernatants taken from M2 bone marrow derived macrophages correlated with this data. M2 macrophages were the predominant population in vivo during both oral and intraperitoneal infections. Because M2 macrophages are poor defenders against bacterial infection, these data …
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Human mesenchymal stromal cell regulation of pulmonary macrophage populations in the Acute Respiratory Distress Syndrome
… their efficacy in clinical samples. The alveolar macrophage (AM) is key to orchestrating the inflammatory response in lung injury highlighting the AM as an ideal therapeutic target. hMSCs are known for their immunomodulatory capacity and so it was hypothesised that hMSCs could modulate human …
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Soy Isoflavones Mediate Radioprotection Of Normal Lung Tissue By Modulating The Radiation-Induced Inflammatory Response
… inflammatory processes involving macrophages, neutrophils, and myeloid-derived suppressor cells. </p> <p>The major findings of this work suggest that soy isoflavones can inhibit inflammatory responses triggered by a single dose of thoracic irradiation in the lung, including NF-κB …
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Effects of Repetitive Intermittent Hypoxia after Acute and Chronic Spinal Cord Injury
… lesion site, there was no change in markers of macrophage or astrocyte phenotype after acute SCI. After chronic SCI there was increased CD206, a pro-repair M2 macrophage marker after 7 days of AIH treatment which did not persist after 12 weeks of treatment. There was also a non-significant trend …
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Combating HIV-1 by Targeting Drug Efflux Transporters on the Macrophage Reservoir
… antiretroviral drug therapy (ART). Infected macrophages, which represent a long-term viral reservoir have been shown to lead to viral rebound independently. In response to the environmental stimuli, macrophages can be polarized into different phenotypes: the pro-inflammatory M1 and the …
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Probiotic Modulation of Mucosal Immune Responses in an In Vitro Co-Culture Model
… modulation of the gut immune system. Gut mucosal macrophages play a pivotal role in driving mucosal immune responses. The local environment and macrophage subset determine immune response: tolerance, associated with an M2-like, regulatory macrophage phenotype and inflammatory activation with an …
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The influence of ECM on mesenchymal stromal/stem cell activity and their interactions with monocytes/macrophages
… stromal/stem cells (MSCs) and monocytes/macrophages within dynamically changing ECM proteins found at the injury site. We hypothesized that this interaction plays a pivotal role in determining the outcome of tissue repair. In our investigation, we first characterised the deposition and …
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THE ROLE OF CIRCULAR RNA CDR1AS IN MACROPHAGE MEDIATED CARDIAC INJURY AND REPAIR
… diseases. In response to cardiac injury, macrophages are initially recruited to the infarcted myocardium and undergo phenotypic change from pro-inflammatory (M1) macrophages in the early stage to an anti-inflammatory (M2) macrophages phenotype in the later stage, orchestrating the …
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Functional properties of galectin-3. Beyond the sugar binding.
… often supported by the activity of different macrophages. Proteins from galectin family were found to contribute to disease pathophysiology. Therefore, there is an intensive interest in understanding different galectin functions. The aim of this thesis was to pin-point specific galectin-3 …