Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"M2 activation"”.
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Signaling Cross-Talk Regulating the Expression of Arginase 1 in Murine Macrophages
… M1 (inflammatory and antimicrobial) or to the M2 (wound repair and inflammation resolution) phenotype. Expression of arginase 1 in macrophages is a key marker of the M2 phenotype. Arginase 1 expression is induced by interleukin 4 (IL-4), a cytokine secreted by Th2 helper cells. All-trans …
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Characterization of interleukin-4 induced gene-1 (IL-4I1) as a host immunoregulator to cutaneous leishmaniasis in cell based models
Macrophage activation can be split into two distinct groups: Classically-Activated (M1) and Alternatively-Activated (M2) macrophages. Each are associated with a certain immune response; in the context of cutaneous leishmaniasis caused by infection with Leishmania major. Specifically, M1 macrophages …
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THE ROLE OF IL-¿¿1 RECEPTOR-¿¿ASSOCIATED KINASE 4 IN MICROGLIAL ACTIVATION IN ALZHEIMER’S DISEASE
… Together, our results demonstrate that IRAK4 activation in later stages of disease impairs clearance of A¿¿ and is correlated with engagement of a proinflammatory gene program. Importantly, they reveal that the previously unappreciated IRFs may be critical to regulating the microglial response …