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Showing 1 to 11 of 11 for “"M2 Protein"”.

  1. The intracellular transport and cell surface expression of the influenza A virus M2 protein.

    Hughey, Patsy Grant

    uab Repository record

  2. Structure and dynamics of full-length M2 protein of influenza A virus from solid-state NMR

    Liao, Shu-Yu, Ph. D. Massachusetts Institute of TechnologyMassachusetts Institute of Technology2017

    … elucidate the structure and dynamics of membrane proteins and fibrils that are difficult to characterize by Xray crystallography or solution NMR. This thesis focuses on the structure determination and the proton conduction mechanism of the full-length matrix protein 2 (M2) of influenza A virus. …

    mit Repository record

  3. Solid-state nuclear magnetic resonance investigations of the influenza M2 protein : structure and dynamics characterization of channel gating and conduction

    Williams, Jonathan K. (Jonathan Kyle)Massachusetts Institute of Technology2017

    … and gating are investigated in the influenza AM2 and BM2 proton channels bound to native-like lipid bilayers. Using pH-dependent 15N chemical shifts of the conserved Histidine residue, we have found that the proton conduction mechanism is the same in all of the M2 channels (WT AM2, S3 IN AM2, …

    mit Repository record

  4. Characterization of the Glycosylation and Signal Peptide Sequences Within the Vaccinia Virus M2 Protein and Influence on ERK1/2 and Nf-Kappab Activation

    Hinthong, OliviaUniversity of Illinois at Urbana-Champaign2015

    This dissertation elaborates on M2's molecular functioning as a viral immunomodulator to inhibit both the ERK1/2 and NF-kappaB pathways, which is reliant on its glycosylation status and proper cellular trafficking within the infected cell. As M2 has no homology to any known viral or cellular …

    uiuc Repository record

  5. Characterization of the glycosylation and signal peptide sequences within the vaccinia virus m2 protein and influence on ERK1/2 and NF-kB activation

    Hinthong, OliviaUniversity of Illinois at Urbana-Champaign2011

    … state via upregulation of proinflammatory proteins. Wild-type vaccinia virus (VV) strains subvert the immune response by expressing proteins that interfere with nuclear translocation of NF-κB. In contrast, infection with an attenuated strain, MVA, results in host cell NF-κB activation. …

    uiuc Repository record

  6. The Role Of The Membrane Proximal Region Of The M2 Cytoplasmic Tail In Virus Replication

    Stewart, Shaun2013

    Influenza A virus encodes M2, a proton channel that has been shown to be important during virus entry and assembly. The primary aim of this thesis was to investigate the role of the membrane proximal region, residues 46-69, of the M2 cytoplasmic tail during virus replication. A cholesterol …

    wustl Repository record

  7. PHYSICOCHEMICAL STUDIES ON THE CATALYTIC AND REGULATORY SUBUNITS OF RIBONUCLEOTIDE REDUCTASE FROM CALF THYMUS

    MATTALIANO, ROBERT JOSEPH

    <p>The catalytic (M2) and regulatory (M1) subunits of calf thymus ribnucleotide reductase have been purified to homogeneity. Each runs as a single band in SDS-polyacrylamide gel electrophoresis with polypeptide molecular weights of 84,000 for M1 and 58,000 for M2. Additional evidence for …

    unh-thes Repository record

  8. The function of the hepatitis C virus p7 protein

    Ann L WozniakThe University of Texas Medical Branch2010

    … developing new therapeutic targets. The HCV p7 protein is critical for virus production and an attractive antiviral target. p7 is an ion channel when reconstituted in artificial lipid bilayers, but channel function has not been demonstrated in vivo and it is unknown whether p7 channel activity …

    utmb Repository record

  9. Development and Application of Solid-State NMR Methods for Investigating Protein Structure and Dynamics

    Gelenter, Martin D.Massachusetts Institute of Technology2021

    … the study of novel systems to understand protein structure and function. Obtaining long-range distance restraints is imperative for solving high-resolution protein structures via SSNMR. Third-spin-assisted recoupling (TSAR) experiments have been shown to be extremely useful in obtaining …

    mit Repository record

  10. Production of plant-expressed virus-like particle vaccines against infectious bronchitis coronavirus and vaccine efficacy in chickens

    University of Pretoria2022

    … produced using Agrobacteriummediated transient protein expression in Nicotiana benthamiana plants as potential vaccines against IBV. Modifying the full-length IBV Spike (S) protein resulted in high levels of VLPs resembling native IBV particles visualised under transmission electron microscopy. …

    pretoria Repository record

  11. Design and production of a candidate universal influenza A vaccine in Nicotiana benthamiana plants

    De Figueiredo Pinto Gomes Pera, FranciscoDepartment of Molecular and Cell Biology2017

    … The 23-amino acid extracellular domain of the M2 protein (M2e) is highly conserved among different influenza A strains and thus it seems like an ideal candidate for a universal influenza vaccine. However, due to its small size, it is a poor immunogen when used on its own. The aim of this …

    cape-town Repository record