Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 1558 for “"M2"”.
-
M2: An architectural system for computer design
… significant opportunities for optimization exist;M2 is an architectural system for computer design. It consists of language tools, architectural tools, and implementation tools. The language tools gather information about programs at compile time and at execution time. This information is used by …
-
Superfícies helicoidais com curvatura média constante em M2 × R
… não-nula invariantes por movimento helicoidal em M2 × R em que M2 é uma forma espacial bidimensional. No âmbito dessa pesquisa, exploramos o Lema de Bour, que consiste em munir uma superfície com parâmetros especiais (s, t) de modo que sua métrica seja da forma ds2 + U (s)2 dt2 , no qual U (s) é …
-
M2 Polarization and Pro-Fibrotic Transition of Lupus Nephritis Macrophages
… IL-6, and TNF-α, whereas alternatively activated M2 macrophages support immune regulation and tissue repair processes. However, in LN, increased infiltration of CD163⁺ M2 macrophages is associated with disease severity and fibrotic remodeling, suggesting that sustained reparative signaling may …
-
Investigation of M2 and anti-segregation process HSS flat broaching tools.
… comparison has been done between conventional M2 and Anti-Segregation Process (ASP) ASP53 and ASP30 high speed steel broach samples. The ASP53 was a development material. The cutting performance was evaluated by measuring the cutting forces and calculating the specific cutting energy, an …
-
Aminosubstituierte Terphenyle als neue Leitstruktur für allostere Modulatoren muscarinischer M2-Acetylcholinrezeptoren
… enthalten mit großer Prävalenz muscarinische M2-Rezeptoren. Es wurden Gleichgewichtsbindungs- und Dissoziationsexperimente durchgeführt. Bis jetzt sind noch nicht alle Verbindungen getestet worden. Die bisher getesteten Verbindungen weisen alle eine Affinität zum mit [3H]-N-Methylscopolamin …
-
Structure and dynamics of influenza M2 proton channels from solid-state NMR
… these infectious virions. The matrix-2 protein (M2) is an essential viral protein that conducts protons in the endosomes of infected host cells and induces membrane curvature to facilitate virus budding. M2's proton channel activity is encapsulated by a transmembrane domain (TM) that is targeted …
-
Clinical review and experimental evaluation of tumour M2-pyruvate kinase in pancreatic cancer
… reviewed the available literature on Tumour M2-PK, a dimeric form of M2 isoenzyme of pyruvate kinase, in GI cancer and carried out a meta-analysis of the clinical data on pancreatic cancer. Experimental work evaluated the measurement of M2-pyruvate kinase in human pancreatic cancer cell lines …
-
Macrophage Polarization (M1/M2) and its Role in Wnt5a Secretion/Expression in Atherosclerosis
… and their progression. The presence of M1 and M2 macrophages in human atherosclerotic lesions has been suggested. Wnt5a is a noncanonical member of the wingless family of proteins that is expressed in human macrophages in different inflammatory diseases including atherosclerosis. These …
-
The Role Of The Membrane Proximal Region Of The M2 Cytoplasmic Tail In Virus Replication
Influenza A virus encodes M2, a proton channel that has been shown to be important during virus entry and assembly. The primary aim of this thesis was to investigate the role of the membrane proximal region, residues 46-69, of the M2 cytoplasmic tail during virus replication. A cholesterol …
-
Synthese und Charakterisierung allosterer Modulatoren muscarinischer M2-Rezeptoren : Strukturvariationen der Bis(ammonium)alkan-Verbindung W84
… Bindungsstelle allosterer Modulatoren des M2-Rezeptors befindet sich im weniger konservierten extrazellulären Bereich. Somit sind allostere Modulatoren in der Lage, spezifisch an einen der Rezeptorsubtypen zu binden. Als Leitstruktur zum Entwurf der im Rahmen dieser Arbeit synthetisierten …
-
Structure and dynamics of full-length M2 protein of influenza A virus from solid-state NMR
… mechanism of the full-length matrix protein 2 (M2) of influenza A virus. The M2 membrane protein can be separated into three domains: an N-terminal ectodomain (1-2 1), an cc-helical transmembrane domain (TM) (22-46) connected to an amphipathic helix (AH) and a Cterminal cytoplasmic tail (63-97). …
-
REGENERATION OF ELECTROSPUN BIORESORBABLE VASCULAR GRAFTS: A PHENOMENON ASSOCIATED WITH VASCULAR GRAFT PROPERTIES AND MACROPHAGE PHENOTYPES (M1/M2)
… (M1) or angiogenic/wound healing (M2) phenotypes depending upon the environmental stimuli. The phenotypic profile of MФ as M1 or M2 following exposure to the biomaterial can dictate the downstream processes of tissue remodeling and angiogenesis. An analysis of how these two cell …
-
Structure and function of the Influenza membrane protein M2 by magic angle spinning NMR and dynamic nuclear polarization
… resonance (NMR) applied to the membrane protein M2 from Influenza A, a small helical transmembrane proton transporter that is the target of adamantane based inhibitors but which is now drug resistant due primarily to the point mutation S31N. The development of techniques that boost the …
-
Exosomal Communication By Metastatic Osteosarcoma Cells Modulates Alveolar Macrophages to An M2 Tumor-Promoting Phenotype and Inhibits Tumoricidal Functions
… of tumor promoting immunosuppressive M2<em> </em>macrophages in the metastases and poor patient survival. By contrast, M1<em></em>macrophage predominance correlates with longer survival. M2 macrophages can be induced by various stimuli in the tumor microenvironment, including exosomes, …
-
Modelado numérico tridimensional de la dinámica de marea M2 en la Bahía de Algeciras y el Estrecho de Gibraltar
… principales ligados a la dinámica de marea M2 en el estrecho de Gibraltar y la bahía de Algeciras. La dinámica de marea M2 para el ambiente general del estrecho de Gibraltar muestra el conocido patrón estacionario con amplitudes en descenso desde el extremo occidental hacia el oriental, y …
-
AN OBSERVATIONAL STUDY IN LIVERPOOL OF PREGNANT WOMEN WITH A BMI ≥ 35kg/m2 REGARDING DIETARY INTAKE, LIFESTYLE AND LIVED EXPERIENCE
… guidelines.MethodsPregnant women with a BMI≥35kg/m2 were recruited from antenatal clinic and asked to complete 3 day food diaries at 16,28 and 36 weeks gestation, The diaries were verified using a food atlas and analysed using Microdiet. A subset of women were then followed up and interviewed …
Page 1 of 78