Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"M1 protein"”.
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Characterization of the vaccinia virus M1 protein on caspase inhibition and the MVA/5.2KB virus on immunogenicity
… identification and characterization of the VACV M1 protein as a caspase inhibitor and (ii) investigating a previously unexplored method to alter the immunogenicity of the attenuated VACV MVA. One anti-viral host response inhibited by VACV during infection is apoptosis. The attenuated MVA strain …
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On the induction of inflammatory reactions by Streptococcus pyogenes
… thesis explores how different streptococcal proteins interfere with innate immunity, adaptive immunity, and blood coagulation. M protein is a surface-bound streptococcal virulence factor with antiphagocytic properties. M proteins can be released from the bacterial surface, and in the present …
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Actions of Antimicrobial Peptides and Bacterial Components in Inflammation
… Streptococcus pyogenes, carrying a surface protein named M1 being fundamental for its virulence, is the major cause of severe streptococcal infections like streptococcal toxic shock syndrome and necrotizing fasciitis. We found that M1 protein is able to induce vascular nitric oxide (NO) …
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Molecular and microscopical analysis of pathogenic streptococci - studies on surface proteins interacting with human cells and extracellular matrix
… between bacterial surface structures and human proteins might determine the outcome of the infection. Streptococcus pyogenes (S. pyogenes), is a human pathogen mostly causing localized infections of the skin and respiratory tract, but it is also capable of causing severe invasive disease such as …
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Platelets and their immunomodulatory roles during Streptococcus pyogenes infection
… S. pyogenes contains a cell wall anchored M protein, which is an important virulence factor that can interact with many cells of the immune system. One of the smallest and most rapidly responding cells in our bloodstream are platelets and they are a main focus for the studies presented in …
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Analysis of the molecular interplay between Streptococcus pyogenes and its human host
… a number of secreted or cell wall-anchored proteins that modulate the human immune system and facilitate colonization and spread of the pathogen in the human host. During S. pyogenes infections, human plasma leaks into the site of infection as a consequence of inflammation. This thesis shows …
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Influenza Viral Protein Interaction Detecting Methods Development and A.M1-host Interplay Network Investigation
… complex subunits interaction. In addition to two protein complementation assays, Split luciferse complementation assay (SLCA), and Bimolecular Fluorescence Complementation (BiFC), LUMIER (luminescence-based mammalian interactome mapping) assay were also developed and used in this study. We …
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Design and production of a candidate universal influenza A vaccine in Nicotiana benthamiana plants
… The 23-amino acid extracellular domain of the M2 protein (M2e) is highly conserved among different influenza A strains and thus it seems like an ideal candidate for a universal influenza vaccine. However, due to its small size, it is a poor immunogen when used on its own. The aim of this project …
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Host modulation of excessive innate immune responses
… peptides and p33 (globular C1q receptor), a protein that can modulate cell injury. We show in vitro how recombinant p33 binds and neutralizes cytotoxic effects of the host-defense peptides human beta defensin 3 and LL-37. Moreover, treatment with p33 was also shown to modulate the sepsis-like …
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Complement aberrations and autoantibodies to complement proteins in relation to disease mechanisms.
… of mannan-binding lectin (MBL) and antibodies to proteins from a potentially nephritogenic Streptococcus pyogenes strain (serotype M1 strain AP1) were investigated in 73 patients with acute poststreptococcal glomerulonephritis (AGN). Antibody responses to the serotype M1-related antigens M1, …