Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"M1 macrophage"”.
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Chemokine Ligand-3 (CCL3) as a Novel Mediator of Inflammatory Bowel Disease Activity
… system, driven in part by pro-inflammatory macrophage polarization. Chemokine ligand-3 (CCL3) is a chemokine known to mediate Th1 responses in inflammatory conditions and act to polarize M1 macrophages at the site of inflammation. CCL3 is upregulated in patients with IBD but its contribution …
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Combating HIV-1 by Targeting Drug Efflux Transporters on the Macrophage Reservoir
… antiretroviral drug therapy (ART). Infected macrophages, which represent a long-term viral reservoir have been shown to lead to viral rebound independently. In response to the environmental stimuli, macrophages can be polarized into different phenotypes: the pro-inflammatory M1 and the …
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Benefits of Quercetin on Metabolic and Inflammatory Biomarkers in High Fat Diet Induced Obesity: A Dose Response Study
… 0.2% & 2%) of quercetin on obesity markers, macrophage populations, and inflammatory mediators in a mouse model of high fat diet induced obesity. Our high fat diet treatment was 16 weeks and based on the American Standard Diet that contains approximately 40% of calories from fat (12% …
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Studies of the role of nf-κb in controlling osteoclast differentiation and bone loss
… through stimulation of the expression of macrophage colony stimulating factor (M-CSF) receptor, c-Fms, and switching M-CSF-induced resident (M2) to inflammatory (M1) macrophages with enhanced OC forming potential and increased production of inflammatory factors through induction of NF-κB …
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Soy Isoflavones Mediate Radioprotection Of Normal Lung Tissue By Modulating The Radiation-Induced Inflammatory Response
… inflammatory processes involving macrophages, neutrophils, and myeloid-derived suppressor cells. </p> <p>The major findings of this work suggest that soy isoflavones can inhibit inflammatory responses triggered by a single dose of thoracic irradiation in the lung, including NF-κB …
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Linking Inflammation to Tumorigenesis In A Mouse Model of High-Fat Diet-Enhanced Colon Cancer: Does Fat Type Matter?
… tissue inflammation, overall expression of macrophages was significantly increased in the HFD-12% group, and HFD-12% and 6% increased the M1 macrophage sub-population. This suggests that a high-fat diet can promote infiltration of macrophages in the adipose tissue, specifically activating …
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THE ROLE OF CIRCULAR RNA CDR1AS IN MACROPHAGE MEDIATED CARDIAC INJURY AND REPAIR
… diseases. In response to cardiac injury, macrophages are initially recruited to the infarcted myocardium and undergo phenotypic change from pro-inflammatory (M1) macrophages in the early stage to an anti-inflammatory (M2) macrophages phenotype in the later stage, orchestrating the …
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Functional properties of galectin-3. Beyond the sugar binding.
… often supported by the activity of different macrophages. Proteins from galectin family were found to contribute to disease pathophysiology. Therefore, there is an intensive interest in understanding different galectin functions. The aim of this thesis was to pin-point specific galectin-3 …