Global ETD Search
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Showing 1 to 2 of 2 for “"M1 activation"”.
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Characterization of interleukin-4 induced gene-1 (IL-4I1) as a host immunoregulator to cutaneous leishmaniasis in cell based models
Macrophage activation can be split into two distinct groups: Classically-Activated (M1) and Alternatively-Activated (M2) macrophages. Each are associated with a certain immune response; in the context of cutaneous leishmaniasis caused by infection with Leishmania major. Specifically, M1 macrophages …
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THE ROLE OF IL-¿¿1 RECEPTOR-¿¿ASSOCIATED KINASE 4 IN MICROGLIAL ACTIVATION IN ALZHEIMER’S DISEASE
… Together, our results demonstrate that IRAK4 activation in later stages of disease impairs clearance of A¿¿ and is correlated with engagement of a proinflammatory gene program. Importantly, they reveal that the previously unappreciated IRFs may be critical to regulating the microglial response …