Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"M.tb"”.
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Development of a Humanized Mouse Model to Understand M.tb and HIV/M.tb Co-infection
Mycobacterium tuberculosis (M.tb) is the most common co-infection and leading cause of death among HIV+ individuals. Several animal models are available to study TB infection although many do not reproduce disease pathology similar to humans. The human host tropism of HIV limits its study in animal …
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Synthesis and evaluation of M.tb Glycosyltransferase (MshA) inhibitors
… (XDR) strains of Mycobacterium tuberculosis (M.tb) against the known anti-tuberculosis drug regimens has prompted the need to search for new anti-tubercular drugs. In this study we report the design and synthesis of a series of thiazolidinethione derivatives and substrate mimics, aimed at …
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Structural and mechanistic investigation towards the regulation of M.tb isocitrate lyase
… and survival of Mycobacterium tuberculosis (M. tb) during infection. It is a key enzyme of the glyoxylate shunt and the methylcitrate cycle, metabolic pathways that are central to the bacteria’s carbon and lipid metabolism. The absence of ICL in mammals makes it a potential inhibition target for …
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Pathology and mechanisms of increased M.tb growth and dissemination during co-infection with HIV-1
… infected with Mycobacterium tuberculosis (M.tb). M.tb and HIV have a deadly synergy that occurs during co-infection. Individuals with HIV infection are at significantly increased risk for acquiring or reactivating latent TB infections. Further, there is increased TB pathology and bacterial …
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Characterisation of a public T cell clonotype enriched in m.tb infected individuals who do not progress to tuberculosis
… important role in controlling M. Tuberculosis (M.tb) infection, but it is not known if specific T cell clones contribute to the outcome of M.tb infection. We recently completed a bulk T cell receptor (TCR) sequencing screen and observed that frequencies of a particular donor-unrestricted T cell …
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Characterisation of T cell specificity, functional, activation and memory profiles associated with QuantiFERON TB Gold conversion and reversion
… acquisition of Mycobacterium tuberculosis (M.tb) infection is associated with a higher risk of tuberculosis disease, compared with remote, asymptomatic infection. M.tb infection, defined by a positive tuberculin skin test (TST) and/or IFN--release assay [IGRA e.g. QuantiFERON TB GOLD (QFT)], …
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The role of antibodies in tuberculosis
The role of antibodies in tuberculosis (TB) has been debated for over a century. Antibodies against Mycobacterium tuberculosis (M.tb) are detectable in persons who appear to resist M.tb infection, and yet humoral immune activation is a consistent biomarker of TB disease progression. Antibody …
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Studies on CD4+ T cell subsets in Mycobacterium tuberculosis immunity during HIV co-infection
Tuberculosis (TB) is a global pandemic which resulted in 5.8 million disease cases and approximately 1.5 million deaths worldwide in 2020. TB disease is the leading cause of death worldwide from a single infectious agent, Mycobacterium tuberculosis (M.tb). It is estimated that a one fourth of the …
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Characterisation of Mycobacterium tuberculosis specific T cell immunity with HLA class II tetramers
Tuberculosis (TB) remains a global health burden, with an estimated 1.3 million people dying from the disease in 2012. Protective immunity against TB is thought to depend on specific T cells. However, exactly which T cell characteristics are required for immunological protection is unknown. To gain …
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The burden of Perinatal Tuberculosis in HIV-infected mothers and their infants
… has the highest national burden of tuberculosis (TB) and the largest number of HIV-infected people in the world. HIV infection, Mycobacterium tuberculosis (M.tb) infection and TB disease is most common during a woman’s reproductive age, particularly in South African women. HIV co-infection …
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Development of novel T cell assays and assessment of immune recognition to latency associated M.tuberculosis-specific antigens Rv2660 and Rv2659
… the discovery of Mycobacterium tuberculosis (M.tb), the causative agent of tuberculosis, yet today it is estimated that 1 in every 3 of the worldʼs population is infected with this pathogen. In South Africa alone there were approximately 1000 new TB cases per 100 000 population in 2007, ranking …
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The Role of Inflammation in the Pathobiology of TB/HIV Co-infection
Mycobacterium tuberculosis (M.tb), the etiological agent of tuberculosis (TB), is the leading cause of death in people living with Human Immunodeficiency Virus (HIV). Treatment of co-infected persons is challenging due to the aggressive course of both individual diseases, and often is further …
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The Role of Inflammation in the Pathobiology of TB/HIV Co-infection
Mycobacterium tuberculosis (M.tb), the etiological agent of tuberculosis (TB), is the leading cause of death in people living with Human Immunodeficiency Virus (HIV). Treatment of co-infected persons is challenging due to the aggressive course of both individual diseases, and often is further …
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Multivariate analysis of the immune response upon recent acquisition of Mycobacterium tuberculosis infection
Tuberculosis (TB), caused by the pathogen Mycobacterium tuberculosis (M.tb), is the leading cause of mortality due to an infectious agent worldwide. Based on data from an adolescent cohort study carried out from May 2005 to February 2009, we studied and compared the immune responses of individuals …
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Development of an Autologous Human Dendritic Cell Vaccine against Mycobacterium tuberculosis in Patients with Extensively Drug-Resistant Tuberculosis
… Extensively drug-resistant tuberculosis (XDR-TB), and resistance beyond XDR-TB (often untreatable), is an increasing public health concern globally. Drug resistance has outpaced the drug development pipeline. Therefore, alternative immunotherapeutic approaches are urgently needed. In this …
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Systems analysis of the CD4 T cell response induced by the novel subunit tuberculosis vaccine, H1:IC31
… and to examine the effects of latent M. tb infection on these responses. We had two broad objectives: Firstly, to determine the effects of latent M. tb infection on epitope recognition by mycobacteria-specific CD4 T cells and to design HLA class II tetramers for detection of these cells. …
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Utility of newer technologies for the diagnosis of active and latent tuberculosis
… only available test for latent tuberculosis (LTBI). Recently, interferon-gamma release assays (IGRAs) have been developed which are based upon the responses of peripheral blood effector cells to M.tb-specific antigens [early secretory antigenic target -6 (ESAT-6) and culture filtrate protein …
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Statistical modelling to determine the influence of vaccine dose and prior Mycobacterium tuberculosis exposure on antigen-specific T cell responses
… vaccines H1:IC31 and H56:IC31 as well as prior M.tb sensitization on the immune responses of three cohorts of South African adolescents and adults. The primary outcomes are frequencies of antigen-specific CD4 T cells expressing different combinations of immunological markers over three time …
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The role of the cytolytic mediators, granulysin and perforin, in tuberculosis
… of protective immunity against tuberculosis (TB) and mediate granule-dependent killing of infected cells. Granulysin, an antimicrobial protein, and perforin, a pore-forming molecule, have been found to co-localise in the granules of these two cell types. Granulysin has been shown to be …
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Proteomic analysis of the Mycobacterium avium-containing phagosome membrane
… like [Mycobacterium tuberculosis] M.tb and Mycobacterium avium (M.av), reside intracellularly in phagosomes where they are able to survive, because they block the process of phagosome maturation. ... An approach of characterizing M.av-containing phagosomes in terms of cell …
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