Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 149 for “"M. tuberculosis"”.
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Molecular epidemiology of M. Tuberculosis transmission in the United Arab Emirates
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. The people from South East Asian countries constitute the bulk of immigrant resident work force in the United Arab Emirates (UAE) and neighboring Gulf Countries. It is a common believe that TB infected expatriates, are …
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Characterisation of bedaquiline resistance mediated by the <i>M. tuberculosis</i> MmpS5L5 efflux pump
Until recently, the treatment of drug-resistant tuberculosis required prolonged antibiotic treatment, often up to two years, with a toxic combination of less effective drugs. Bedaquiline, an antibiotic that targets the mycobacterial ATP synthase, has revitalised the ability to treat …
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Development and testing of recombinant B. abortus RB51 vaccine strains carrying M. tuberculosis protective antigens
Tuberculosis, caused by Mycobacterium tuberculosis, is one of the most prevalent infectious diseases inflicting humankind. The World Health Organization estimates that one third of the world's population, approximately 2.2 billion people, is infected with TB with a mortality of 1.7 million people …
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Remodelling of Mycobacterial Peptidoglycan During Cell Division and the Epigenetics of Macrophages during M. tuberculosis infection
Tuberculosis (TB) has emerged as the world’s most deleterious infectious disease. The etiological agent of TB, Mycobacterium tuberculosis (Mtb), has evolved the ability to evade the host immune system using several mechanisms; emphasising the need for novel treatment strategies. Peptidoglycan (PG) …
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On the role of treml6 in B-1a B cell development And ICOS co-stimulation in adaptive immune responses against M. tuberculosis
TREM Rezeptoren sind aus infektionsimmunologischer Sicht von großem Interesse, da sie TLR Signale inhibieren bzw. verstärken können und somit in der Lage sind, inflammatorische Immunantworten zu regulieren. Diese Doktorarbeit untersucht die immunologische Funktion von murinem TLT-6 (Gen: treml6), …
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Targeting Trehalose and Methylglucose Lipopolysaccharide Biosynthetic Pathways in M. tuberculosis - Structural and Functional Characterisation, and Early-Stage Drug Discovery of OtsA and Rv3030
Mycobacterium tuberculosis, the causative agent of tuberculosis in humans, is one of the most successful pathogens, with much of its virulence predominantly associated with its thick, lipid rich cellular envelope that modulates the host immune response. Tuberculosis, having a long history, has …
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Design and synthesis of inhibitors of dTDP-D-glucose 4,6-dehydrate (Rm1B), and enzyme required for dTDP-L-rhamnose production in M. tuberculosis
… that could act as therapeutics for Mycobacterium tuberculosis. The necessity for newer, more effective treatments for tuberculosis is growing, as the bacteria evolve resistance to traditional treatments. In an effort to develop more effective and perhaps more abbreviated courses of treatment, a …
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Rationalising the inhibition of M. tuberculosis MshB by a series of inhibitors constructed from plumbagin conjugated via a viariable alkyl linker to a phenyl thioglycoside
Infection by M. tuberculosis results in an estimated 1.7 million TB related deaths worldwide. Mycothiol is produced in M. tuberculosis as the dominant low molecular weight thiol and is thought to protect the bacteria against oxidative stress. Since mycothiol is unique to Actinomycetes and is also …
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Investigating permeation of anti-mycobacterial agents in Mycobacterium tuberculosis and M. tuberculosis-infected macrophages in vitro as a model for early stage tuberculosis drug discovery
Tuberculosis (TB) is the leading cause of death due to a single infectious disease and remains a major threat to global public health. The increasing emergence of multi-drug resistance to current anti-TB drugs, exacerbated by the long treatment duration, highlights the need for new effective …
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Mechanisms of Macrophage Detection and Control of Mycobacterium tuberculosis Infection
… to recognize and respond to Mycobacterium tuberculosis infection. Macrophage recognition of M. tuberculosis is characterized by the production of a robust type I interferon response dependent on the activation of a cytosolic surveillance pathway by the recognition of M. tuberculosis DNA in …
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Mycobacterium Tuberculosis Virulence Factor Mpt64 Targets the Endoplasmic Reticulum
Mycobacterium tuberculosis, the causative agent of tuberculosis, is one of the most successful human pathogens. One reason for its success is that M. tuberculosis can reside within host macrophages, a cell type that normally functions to phagocytose and destroy infectious bacteria. However, M. …
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Investigation of the Genetic Basis of Antibiotic Resistance in Mycobacterium tuberculosis
… of antibiotic resistant strains of Mycobacterium tuberculosis, coupled with the time it takes to perform phenotypic drug susceptibility testing of this organism, makes the treatment of tuberculosis increasingly difficult. Several genotypic assays for the rapid detection of drug resistance in M. …
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The role of CD43 in the growth and pathogenesis of Mycobacterium tuberculosis within the mammalian host
Mycobacterium tuberculosis exploits various molecules on host cells to gain entry and establish a niche for survival and replication. We characterized the role of the glycoprotein CD43 in the pathogenesis of M. tuberculosis. Using gene-deleted mice (CD43-/-), we assessed association of the …
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Biomarkers and cell phenotypes in TB patients with minimal or persisting lung inflammation post-anti-TB treatment and ex-vivo atorvastatin immunomodulatory effects on M. tuberculosis-infected PBMC
Unresolved lung inflammation post-anti-TB treatment necessitates the evaluation of additional host-directed therapies (HDT). Statins, recognized for their pleiotropic effects, show potential as immunomodulators to reduce post-TB lung inflammation. The ongoing StatinTB clinical trial utilizes a …
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The mechanistic basis of susceptibility and resistance to the antitubercular drug para-aminosalicylic acid
Tuberculosis (TB) is responsible for the deaths of 1.6 million people worldwide each year and is the leading cause of death by the pathogen Mycobacterium tuberculosis. The treatment regimen for M. tuberculosis involves lengthy, intensive drug therapy that causes severe side-effects. The …
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Identification and characterisation of proteases in Mycobacterium tuberculosis
Virulence determinants of M. tuberculosis remain largely unknown. Of key interest has been the ability of the bacterium to survive intracellularly within its host cell, the macrophage, and its ability to cause extensive tissue necrosis. Exported proteases are commonly associated with virulence in …
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Investigation of the genetic basis of antibiotic resistance in Mycobacterium tuberculosis
… of antibiotic resistant strains of Mycobacterium tuberculosis, coupled with the time it takes to perform phenotypic drug susceptibility testing of this organism, makes the treatment of tuberculosis increasingly difficult. Several genotypic assays for the rapid detection of drug resistance in M. …
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Investigating transmembrane TNF and transmembrane p55TNFR mediated signaling in host immune function during Mycobacterium tuberculosis infection
… of TNF-TNFR signaling in immunity against M. tuberculosis has been established. The aims of this study were to characterize the functions of membrane-bound TNF (Tm-TNF) and soluble TNF (solTNF) and to investigate the role of membrane-bound p55TNFR signaling as well as the in vivo significance …
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