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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 99 for “"M-phase"”.

  1. Regulation of Anaphase Promoting Complex/Cyclosome to Control M Phase Exit

    Tang, Wanli2010

    <p>The Anaphase Promoting Complex/Cyclosome (APC/C) is a RING E3 ligase that plays essential roles both within and outside of the cell cycle. At the onset of anaphase, the APC/C targets cyclin B and securin for degradation, initiating chromosome separation and mitotic exit. Regulation of APC/C …

    duke Repository record

  2. Small Molecule Modulation of the Cell Cycle: Discovery of Anticancer Compounds That Induce G1- and M-Phase Cell Cycle Arrest and Characterization of Their Modes of Action

    Leslie, BenjaminUniversity of Illinois at Urbana-Champaign2014

    … of 8H and other phenylcinnamides that induce M-phase cell cycle arrest and cell death in a variety of cell lines. Also presented in an appendix are the summarized results of an attempt to design isozyme-specific inhibitors of the enzyme Vault Parp using a fragment based in silico screening …

    uiuc Repository record

  3. Cell cycle of Emiliania huxleyi and its effects on host: virus interactions

    Jefferson, Rebecca Louise2004

    … were infected during the G1 , S or G2 + M phase and monitored for 2 hours for adsorption and infection or monitored for 48 hours for virus production, host lysis and host cell cycle. A three fold increase in infection during the G2 + M phase was recorded, however there was no significant …

    plymouth Repository record

  4. Mathematical Modeling of the Budding Yeast Cell Cycle

    Calzone, LaurenceVirginia Tech2000

    … for the Start transition (passage from G1 phase to S/M phase) in budding yeast. In this thesis, my main goal is to extend Chen's model to include new information about the mechanism controlling Finish (passage from S/M phase to G1 phase). Using laws of biochemical kinetics, I transcribed …

    vt Repository record

  5. Genomische Instabilität bei der humanen Ovarialtumorzellinie BG-1 durch hormonelle Proliferationsstimulierung

    Gregor, CarolineUniversität Würzburg

    … FACScans konnten die prozentualen Zellzyklusphasenanteile (G1/ G0-, S- und G2/ M- Phase) der BG-1 Zellen zu verschiedenen Zeiten des Wachstums bestimmt werden. Zum Beispiel war der Anteil an Zellen der östradiolstimulierten Zellpopulation in der G2/ M Phase durchgehend um 6-8 % geringer …

    wurz-thes Repository record

  6. Regulation of Chromosome Segregation by the Chromosomal Passenger Complex

    Tseng, Boo Shan

    … While this phosphorylation is a hallmark of M-phase, its functional significance is enigmatic. In the first part of my thesis, I, with my collaborators, provide a molecular function for this phosphorylation in the chromosomal dissociation of HP1 (heterochromatin protein 1) in M-phase. The …

    rockefeller Repository record

  7. Effects of selenite on metabolic events during the proliferation of canine mammary tumor cells

    Hwang, Kyung HeeUniversity of Illinois at Urbana-Champaign1994

    … fusion occurred. Selenite modulated the S and M phases during the cell cycle. Selenite increased the activity of the 114 KD protein kinase only during the S phase. Selenite treatment during the M phase resulted in a disappearance of a 53 KD kinase and the appearance of a 47 KD kinase. The …

    uiuc Repository record

  8. CDK control of mitotic progression in Saccharomyces cerevisiae

    Rahal, Rami SMassachusetts Institute of Technology2008

    … essential functions in triggering entry into M-phase, where they have established roles in nuclear envelope breakdown, chromosome condensation, and Golgi fragmentation. Whether mitotic CDKs have essential functions within mitosis is unclear. The work presented in this thesis indicates that …

    mit Repository record

  9. A model of the checkpoint response of the cell cycle of frog-egg extracts in the presence of unreplicated DNA

    Dravid, AmitVirginia Tech2004

    … between growth and DNA replication (interphase), and DNA distribution and cell-division (mitosis or M-phase). This process is regulated by a complex network of biochemical reactions. A core part of this network, called the "Cell Cycle engine" is evolutionarily conserved. The dimer of CDK1 …

    vt Repository record

  10. The N-terminal Domain of the Y-box Binding Protein YB-1 Plays a Major Role in Cell Proliferation and Apoptosis

    Khandelwal, Payal2016

    … resulted in cell cycle arrest at the G2/M phase. In contrast, incubation with the APYB36GFP protein showed a lower proportion of G2/M phase cells. APYB26GFP and APYB77GFP protein incubations also resulted in significant apoptosis, which was confirmed by Annexin V staining, DNA fragmentation …

    tenn-hsc Repository record

  11. The Antitumor Agent, Arglabin-DMA, Preferentially Induces Apoptosis in Human Colon Tumor Cells

    Kwon, Sung Wook2019

    … two human colon tumor cells in G<sub>2</sub>/M phase increased, indicating a block in either G<sub>2</sub> or M phase. We conclude that Arglabin-DMA has specific cytotoxic effects in two human colon tumor cell lines, and less cytotoxicity to normal cells. It induces arrest at the G<sub>2</sub>/M …

    odu Repository record

  12. Die Wirksamkeit TRAIL-induzierter Nekroptose gegenüber Tumorstammzellen und zellzyklusarretierten Tumorzellen

    Brummert, MerleChristian-Albrechts-Universität zu Kiel

    … Die Zellen wurden am Übergang der G2- in die M-Phase und der G1/0 in die SPhase arretiert und ebenfalls auf ihre Sensitivität gegen TRAIL-induzierte Nekroptose untersucht. Die Untersuchungen konnten zeigen, dass Holoklone in der G2/M-Phase arretiert werden können und somit ein Modell für ruhende …

    cau-kiel Repository record

  13. PERCEIVED VALUE OF BUILDING INFORMATION MODELING IN FACILITIES OPERATIONS AND MAINTENANCE

    Forns-Samso, Francisco

    … to be successful in the design and construction phase. However, the benefits have not transcended to the O&M phase. Reluctance to process change, lack of knowledge and lack of documented metrics has prevented owners from adopting BIM to support the O&M phase. The purpose of this research is to …

    unm Repository record

  14. Analysing The Effects Of Loss Of Sin3 In Drosophila Melanogaster

    Swaminathan, Aishwarya2010

    … This is in part due to misregulation of the G2/M phase of the cell cycle. SIN3 genetically interacts with STG, a protein important for the G2/M phase of the cell cycle. Loss of SIN3 results in downregulation of STG whereas overexpression of STG in a SIN3 knockdown background is able to rescue the …

    wayne-thes Repository record

  15. An electrophysiological study of chromatic processing in the human visual system. Using visual evoked potentials and electroretinograms to study cortical and retinal contributions to human trichromatic vision.

    Challa, Naveen K.University of Bradford2012

    … ERGs, the L:M ratio was close to unity and L/M phase difference was close to 180°. For high temporal frequency ERGs, the L:M ratio was more than unity and L/M phase difference was close to 90°. In addition to this, the variation in L:M ratio across the retinal eccentricity was also examined. …

    bradford Repository record

  16. The Role of the Stress Response Gene Gadd45b in Senescence

    Magimaidas, AndrewTemple University. Libraries2015

    … to other senescent MEFs, which arrest at G1 phase of cell cycle, Gadd45b null MEFs arrest at the G2/M phase of cell cycle. Furthermore, FACS analysis of Gadd45b null MEFs showed less phospho-histone H3-positive cells compared to wild type MEFs indicating that Gadd45b null MEFs are arrested in …

    temple Repository record

  17. Investigating the mitotic roles of Topoisomerase 2 Alpha and Topoisomerase 2 Beta-Binding Protein 1 in the maintenance of chromosome structure and genome stability

    Benoit, JudithUniversity of Cambridge2024

    … been reported to interact with TOP2A during anaphase. However, most functions of TOPBP1 appear to be independent of Topoisomerase 2 (TOP2), with it acting as a multifunctional scaffold, recruiting factors to the genome during transcription, replication, and the DNA damage response. Recently, a …

    cambridge Repository record

  18. Identification and Characterization of Hells-CDCA7, a Nucleosome Remodeling Complex Required for Mitotic Chromosome Structure

    Jenness, Christopher

    … from Xenopus egg extracts. By comparing interphase and M phase, I reveal how the chromatin proteome is affected by the cell cycle. I find that although topoisomerase II associates with chromatin throughout the cell cycle, its catalytic activity is greatly enhanced in mitosis where it can act …

    rockefeller Repository record

  19. The splicing inhibitor Isoginkgetin leads to defects in multiple phases of the cell cycle

    Rick, Kayleigh R. C. (Ruth Christel)Carleton University2016

    … p53 expressing cells exhibited a remarkable S phase defect while the p53-null subline accumulated with 4C DNA content. Despite the pronounced difference in these isogenic strains, there was no pronounced p53 transcriptional response as assessed by qRT-PCR and preliminary microarray analysis. …

    carleton Repository record

  20. The effects of altered membrane fatty acid composition on the toxic interactions of heavy metals with Saccharomyces Cerevisiae

    Howlett, Niall G.Oxford Brookes University1998

    … from cell division, leading to sequential S phases. For example, DNA levels of up to 8C were evident in 18:3-enriched cells after only 4.5 h exposure to 100 JJ.M Cu(N03h. Using flow cytometry, the heterogeneity in susceptibility to copper toxicity of exponential phase S. cerevisiae was also …

    oxford-brookes Repository record

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